SST Interneuron Subtype Output Specificity: Martinotti vs Non-Martinotti

{
  "papers": [
    {
      "doi": "10.1016/j.neuron.2023.05.032",
      "value": "subtype-selective targeting: SST-Myh8 receives input from PT neurons (SATB2-negative), SST-Nmbr from IT neurons (70-80% SATB2-positive)",
      "method": "morphology/optogenetics",
      "metric": "SST subtype output target",
      "cite_key": "Wu2023",
      "condition": "mouse, S1 and V1, layers 2/3-6, optogenetics, monosynaptic rabies tracing",
      "study_system": "mouse, S1 and V1, layers 2/3-6, optogenetics, monosynaptic rabies tracing",
      "value_source_sentence": "In contrast, the majority (70–80%) of L5 presynaptic neurons to SST-Nmbr interneurons are SATB2-positive, suggesting that they were L5-IT neurons (n = 4, S1 and V1 combined, Figure 6C and Figure S8 )."
    },
    {
      "doi": "10.7554/elife.43696",
      "value": null,
      "method": "morphology/optogenetics",
      "metric": "SST subtype output target",
      "cite_key": "Naka2019",
      "condition": "mouse, neocortex, barrel cortex, in vivo",
      "study_system": "mouse, neocortex, barrel cortex, in vivo",
      "value_source_sentence": null
    },
    {
      "doi": "10.7554/elife.58731",
      "value": "65",
      "method": "morphology/optogenetics",
      "metric": "SST subtype output target",
      "cite_key": "ZorrilladeSanMartin2020",
      "condition": "mouse, rat, neocortex, prefrontal cortex, in vivo",
      "study_system": "mouse, rat, neocortex, prefrontal cortex, in vivo",
      "value_source_sentence": "In the prefrontal cortex of Ts65Dn mice (a well-established DS model), we found that the dendritic synaptic inhibitory loop formed by somatostatin-positive Martinotti cells (MCs) and pyramidal neurons (PNs) was strongly enhanced, with no alteration in their excitability."
    }
  ],
  "comparison_id": "sst-subtype-output-targets",
  "comparison_name": "SST Interneuron Subtype Output Specificity: Martinotti vs Non-Martinotti",
  "comparison_type": "convergent evidence",
  "what_it_reveals": "Different SST subtypes (Martinotti vs non-Martinotti, and various Martinotti subtypes) target distinct dendritic compartments and cell types. This comparison reveals the diversity of inhibitory output from the SST class.",
  "homogeneity_check": {
    "caveats": [
      "Different genetic strategies for targeting subtypes, different measurement approaches"
    ],
    "n_definition": "varies: cells reconstructed, optogenetic mapping experiments",
    "scope_region": "primarily S1 and V1",
    "scope_population": "SST interneuron subtypes"
  },
  "suggested_plot_type": "heatmap"
}

[
  "paper:paper-13553bc98be2",
  "paper:paper-7881c9e4267e",
  "paper:paper-c7076ba88e47"
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "89b7e9787cd90e942b0adb531d549af3ddad30f1",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewSST"
}