Proportions of cardinal interneuron classes across cortical areas

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  "papers": [
    {
      "n": 1300000,
      "doi": "10.1016/j.cell.2021.04.021",
      "value": "~40%",
      "method": "scRNA-seq (10x Chromium)",
      "metric": "Fraction of GABAergic neurons in Pvalb subclass",
      "cite_key": "Yao2021",
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "total cells profiled across isocortex and HPF",
      "scope_region": "entire adult mouse isocortex",
      "study_system": "mouse isocortex",
      "taxonomic_level": "subclass",
      "scope_population": "all GABAergic neurons",
      "value_source_sentence": "Each neighborhood is further divided into 3 subclasses: Lamp5, Sncg and Vip in CGE, and Sst Chodl, Sst and Pvalb in MGE."
    },
    {
      "n": null,
      "doi": "10.1038/s41593-020-0685-8",
      "value": "5 subclasses (Pvalb, Sst, Vip, Lamp5, Sncg)",
      "method": "community consensus from scRNA-seq studies",
      "metric": "Major interneuron subclasses identified",
      "cite_key": "Yuste2020",
      "ci_or_error": null,
      "text_access": "fulltext",
      "n_definition": "consensus classification across multiple datasets",
      "scope_region": "mouse neocortex",
      "study_system": "mouse neocortex",
      "taxonomic_level": "subclass",
      "scope_population": "all GABAergic neurons",
      "value_source_sentence": "Almost perfect correlations were seen between major interneuron subclasses for molecular markers, axonal morphology and kinetics of synaptic inputs31 (Fig."
    }
  ],
  "comparison_id": "fig_sec2_interneuron_proportions",
  "comparison_name": "Proportions of cardinal interneuron classes across cortical areas",
  "comparison_type": "cross-study agreement",
  "what_it_reveals": "Convergence across independent transcriptomic studies on the same cardinal class framework, though exact proportions vary by area and method.",
  "homogeneity_check": "Both studies classify GABAergic interneurons at the subclass level in mouse cortex. Direct proportion comparison is limited because the Cell 2021 paper pools across all isocortex while the community paper synthesizes across studies. Scope_region difference: pan-isocortex vs study-specific.",
  "suggested_plot_type": "grouped_bar"
}

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