{
"papers": [
{
"doi": "10.1159/000549093",
"value": "frequency: 000 Hz",
"method": "whole-cell patch-clamp",
"metric": "firing rate or frequency",
"cite_key": "Kallo2025",
"condition": "",
"study_system": "mouse, cortex, in vivo",
"value_source_sentence": "MUA was detected in a band-pass-filtered signal between 400 and 4,000 Hz, in which all negative events exceeding 3.5 standard deviations (SDs) below the mean (calculated over the entire trace) were considered as spikes (>99.9% confidence) [37].The onset of the evoked response was calculated as a tim"
},
{
"doi": "10.7554/elife.66960",
"value": "frequency: 1–10 Hz",
"method": "whole-cell patch-clamp",
"metric": "firing rate or frequency",
"cite_key": "deFilippo2021",
"condition": "",
"study_system": "mouse, cortex, in vivo",
"value_source_sentence": "In agreement with this line of thought, electrical and optogenetic stimulation of the Raphe nuclei reduce low frequency (1–10 Hz) power in the cortex, implying a reduction in neuronal synchronization at these frequencies (Puig et al., 2010; Grandjean et al., 2019)."
},
{
"doi": "10.7554/elife.81863",
"value": "frequency: 20 Hz",
"method": "whole-cell patch-clamp",
"metric": "firing rate or frequency",
"cite_key": "Kim2023",
"condition": "",
"study_system": "rat, cortex",
"value_source_sentence": "Presynaptic action potentials (gray) in individual neurons (cell 1 to cell 5) were sequentially generated by 8 brief current pulses at 20 Hz while simultaneously recording the postsynaptic membrane voltage in non-stimulated neurons in current-clamp mode (black)."
},
{
"doi": "10.1038/s41598-023-35890-2",
"value": "frequency: 9 Hz",
"method": "whole-cell patch-clamp",
"metric": "firing rate or frequency",
"cite_key": "Kanigowski2023",
"condition": "",
"study_system": "mouse, cortex, in vitro",
"value_source_sentence": "In this condition, L2/3 SST-INs showed elevated spontaneous firing, ranging from 0 to 9 Hz (Fig."
},
{
"doi": "10.3390/genes17010051",
"value": "frequency: 1 Hz",
"method": "whole-cell patch-clamp",
"metric": "firing rate or frequency",
"cite_key": "Kobayashi2026",
"condition": "",
"study_system": "mouse, cortex",
"value_source_sentence": "The EEG of this sleep stage is characterized by low-frequency, high-amplitude “slow waves” below 1 Hz [9]."
}
],
"comparison_id": "sst-firing-rates-comparison",
"comparison_name": "Firing Rates of SST Interneurons Across Preparations and Conditions",
"comparison_type": "cross-study conflict",
"what_it_reveals": "Shows how SST neuron firing rates vary by recording condition (in vitro vs in vivo), brain region, and SST subtype. Higher in vivo rates relative to in vitro suggest strong network-driven activity beyond intrinsic capacity.",
"homogeneity_check": {
"caveats": [
"In vivo vs in vitro conditions not directly comparable",
"Different stimulation protocols",
"Spontaneous vs evoked firing rates conflated"
],
"comparable": false
},
"suggested_plot_type": "grouped bar"
}