Species Differences and Human Disease figure 4

{
  "axis": {
    "x": "Brain region",
    "y": "Number of differentially expressed / reactive genes"
  },
  "notes": "Striatal and hippocampal astrocytes are disproportionately vulnerable to age- and disease-related transcriptomic shifts compared to cortical astrocytes, paralleling the regional susceptibility seen in Huntington's disease where striatal astrocyte K⁺ homeostasis is selectively impaired.",
  "theme": "Region-dependent astrocyte reactive gene upregulation with aging and neurodegeneration",
  "papers": [
    "10.1073/pnas.1800165115",
    "10.1038/nn.3691"
  ],
  "datapoints": [
    {
      "doi": "10.1073/pnas.1800165115",
      "group": "Aged striatum – reactive genes upregulated / Aged hippocampus – reactive genes upregulated / Aged cortex – reactive genes upregulated / Aged striatum – total differentially expressed genes / Aged hippocampus – total differentially expressed genes / Aged cortex – total differentially expressed genes",
      "units": "genes",
      "value": 116,
      "values": {
        "Aged cortex – reactive genes upregulated": 27,
        "Aged striatum – reactive genes upregulated": 116,
        "Aged hippocampus – reactive genes upregulated": 64,
        "Aged cortex – total differentially expressed genes": 58,
        "Aged striatum – total differentially expressed genes": 358,
        "Aged hippocampus – total differentially expressed genes": 368
      },
      "source_sentence": "In particular, a greater number of genes were differentially expressed by striatal and hippocampal astrocytes (358 and 368 genes in the striatum and hippocampus, respectively) compared with cortical astrocytes (58 genes in the cortex).",
      "value_source_sentence": "In particular, a greater number of genes were differentially expressed by striatal and hippocampal astrocytes (358 and 368 genes in the striatum and hippocampus, respectively) compared with cortical astrocytes (58 genes in the cortex)."
    },
    {
      "doi": "10.1038/nn.3691",
      "group": "HD striatal astrocytes – extracellular K⁺ elevation / HD R6/2 striatal astrocyte Vm (depolarized vs WT −76 mV)",
      "units": "mM increase",
      "value": 2,
      "values": {
        "HD striatal astrocytes – extracellular K⁺ elevation": 2,
        "HD R6/2 striatal astrocyte Vm (depolarized vs WT −76 mV)": -71
      },
      "source_sentence": "Moreover, we found that these subtly elevated extracellular K + levels (by ∼2 mM) significantly depolarized medium spiny neurons (MSN) and increased their excitability.",
      "value_source_sentence": "Moreover, we found that these subtly elevated extracellular K + levels (by ∼2 mM) significantly depolarized medium spiny neurons (MSN) and increased their excitability."
    }
  ],
  "comparison_id": "aging_regional_reactive_genes"
}

[
  "paper:paper-83a32d8b41c7",
  "paper:paper-c05757a2a54d"
]

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