Dopamine Dynamics: Beyond the Simple Reward Signal
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1CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
3CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
5CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
6CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
7CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
8CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
9CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 The molecular adaptations surveyed in{ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2. 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5. 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8. 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
3CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 3CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1. 3CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
3CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 3CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4. 3CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
3CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 3CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7. 3CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
3CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9. 5CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and... -
5CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 The cross-species replication of RPE signaling represents a genuine strength of this framework. 5CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
5CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 The cross-species replication of RPE signaling represents a genuine strength of this framework. 5CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
5CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 The cross-species replication of RPE signaling represents a genuine strength of this framework. 5CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
5CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 The cross-species replication of RPE signaling represents a genuine strength of this framework. 5CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
5CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 The cross-species replication of RPE signaling represents a genuine strength of this framework. 6CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
6CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 The cross-species replication of RPE signaling represents a genuine strength of this framework. 6CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
6CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 The cross-species replication of RPE signaling represents a genuine strength of this framework. 6CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
6CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 The cross-species replication of RPE signaling represents a genuine strength of this framework. 6CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
6CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 The cross-species replication of RPE signaling represents a genuine strength of this framework. 6CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
6CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 The cross-species replication of RPE signaling represents a genuine strength of this framework. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
4CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 4CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
7CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 7CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 7CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
7CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 7CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 7CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
7CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 7CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 7CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
7CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 8CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 8CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
8CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 8CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 8CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
8CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 8CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 8CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
8CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 8CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 9CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference0 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
9CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference1 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 9CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference2 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 9CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference3 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
9CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference4 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 9CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference5 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 9CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference6 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
9CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference7 Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. 9CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference8 argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. 9CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference9 mounted a more fundamental critique: while the predominant family of RPE model extensions... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference00 The RPE framework treats DA primarily as a learning signal that updates value estimates 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference01. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference02. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference03 The RPE framework treats DA primarily as a learning signal that updates value estimates 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference04. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference05. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference06 The RPE framework treats DA primarily as a learning signal that updates value estimates 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference07. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference08. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference09 The RPE framework treats DA primarily as a learning signal that updates value estimates 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference10. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference11. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference12 The RPE framework treats DA primarily as a learning signal that updates value estimates 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference13. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference14. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value... -
2CitationThe molecular adaptations surveyed in {ref}
sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference15 The RPE framework treats DA primarily as a learning signal that updates value estimates 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference16. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior 2CitationThe molecular adaptations surveyed in {ref}sec-molecular-adaptations— from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...content/04_dopamine_dynamics.md:line 4Open reference17. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value... -
... 152 additional anchors in refs_json
References
- [Schultz2016] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Berridge2007] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Koob2001] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Lee2024] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Cohen2012a] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Mongia2019] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Fry2025] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Cai2024] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Patriarchi2018] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Siwakoti2025] “The molecular adaptations surveyed in {ref}`sec-molecular-adaptations` — from AMPA receptor trafficking and ΔFosB-mediated transcription to chromatin remodeling and neuroimmune dysregulation — do not occur in a vacuum. They alter the fundamental dynamics of dopamine (DA) signaling in ways that three competing theoretical frameworks attempt, with varying success, to explain [Schultz2016, Berridge2007, Koob2001, Lee20...”
- [Schultz2002] “Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards [Schultz2016, Schultz2002, Schultz2001, Schultz2006]. [Schultz2002] characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and...”
- [Schultz2001] “Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards [Schultz2016, Schultz2002, Schultz2001, Schultz2006]. [Schultz2002] characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and...”
- [Schultz2006] “Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards [Schultz2016, Schultz2002, Schultz2001, Schultz2006]. [Schultz2002] characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and...”
- [Liebenow2022] “Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards [Schultz2016, Schultz2002, Schultz2001, Schultz2006]. [Schultz2002] characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and...”
- [Chase2023] “Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards [Schultz2016, Schultz2002, Schultz2001, Schultz2006]. [Schultz2002] characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and...”
- [Enten2026] “Among the most replicated findings in systems neuroscience is that midbrain DA neurons encode reward prediction errors — the difference between received and predicted rewards [Schultz2016, Schultz2002, Schultz2001, Schultz2006]. [Schultz2002] characterized the canonical pattern: DA neurons display short-latency, phasic activation to unexpected rewards, are suppressed below baseline by unexpected reward omission, and...”
- [Bayer2005] “The cross-species replication of RPE signaling represents a genuine strength of this framework. [Bayer2005] demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for...”
- [Pessiglione2006] “The cross-species replication of RPE signaling represents a genuine strength of this framework. [Bayer2005] demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for...”
- [Moningka2024] “The cross-species replication of RPE signaling represents a genuine strength of this framework. [Bayer2005] demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for...”
- [GarciaLeon2025] “The cross-species replication of RPE signaling represents a genuine strength of this framework. [Bayer2005] demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for...”
- [Yan2025] “The cross-species replication of RPE signaling represents a genuine strength of this framework. [Bayer2005] demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for...”
- [Shang2026] “The cross-species replication of RPE signaling represents a genuine strength of this framework. [Bayer2005] demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for...”
- [Bakhurin2025] “The cross-species replication of RPE signaling represents a genuine strength of this framework. [Bayer2005] demonstrated in non-human primates that midbrain DA neuron firing rates provide a quantitative match to TD model predictions for outcomes better than expected. Critically, this match held only for positive RPEs — negative prediction errors produced responses that did not map as cleanly onto the theoretical for...”
- [Sousa2025] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [Takahashi2026] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [Kahnt2025] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [Mechtenberg2025] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [Usypchuk2025] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [Korbisch2026] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [PanVazquez2025] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [Rouhani2024] “Despite this replication breadth, the RPE framework faces challenges that are growing harder to ignore. [Fry2025] argued that recent findings question whether RPE can fully account for DA function, pointing to evidence that DA neurons encode detailed features of the reward environment beyond simple prediction errors. [Lee2024] mounted a more fundamental critique: while the predominant family of RPE model extensions...”
- [Berridge2009a] “The RPE framework treats DA primarily as a learning signal that updates value estimates [Schultz2016, Schultz2006]. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior [Berridge2007, Berridge2009a]. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value...”
- [Berridge2005] “The RPE framework treats DA primarily as a learning signal that updates value estimates [Schultz2016, Schultz2006]. The incentive salience framework treats DA primarily as a motivational signal that energizes approach behavior [Berridge2007, Berridge2009a]. These are not merely different emphases — they make different predictions about the consequences of pharmacological DA elevation. RPE models predict faster value...”
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