Recording Realities: What In Vivo Technologies Reveal and Conceal
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1CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in{ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra... -
2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA dips during specific phases of drug-seeking that sustained-measurement approaches would integrate away 2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1. These are not simply high... -
2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA dips during specific phases of drug-seeking that sustained-measurement approaches would integrate away 2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3. These are not simply high... -
2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA dips during specific phases of drug-seeking that sustained-measurement approaches would integrate away 2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference5. These are not simply high... -
2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference6 Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA dips during specific phases of drug-seeking that sustained-measurement approaches would integrate away 2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference7. These are not simply high... -
2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference8 Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA dips during specific phases of drug-seeking that sustained-measurement approaches would integrate away 2CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference9. These are not simply high... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA dips during specific phases of drug-seeking that sustained-measurement approaches would integrate away 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1. These are not simply high... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference5. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference6 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference7. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference8 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference9. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference5. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference6 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference7. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference8 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 4CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference9. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference5. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference6 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference7; FSCV from [Wallace2025a, Bai... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference8 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference9; FSCV from [Wallace2025a, Bai... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1; FSCV from [Wallace2025a, Bai... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3; FSCV from [Wallace2025a, Bai... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference5; FSCV from [Wallace2025a, Bai... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference6 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference7; FSCV from [Wallace2025a, Bai... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference8 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference9; FSCV from [Wallace2025a, Bai... -
6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1; FSCV from [Wallace2025a, Bai... -
6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3; FSCV from [Wallace2025a, Bai... -
6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference5; FSCV from [Wallace2025a, Bai... -
6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference6 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference7; FSCV from [Wallace2025a, Bai... -
6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference8 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 6CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference9; FSCV from [Wallace2025a, Bai... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1; FSCV from [Wallace2025a, Bai... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3; FSCV from [Wallace2025a, Bai... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference5; FSCV from [Wallace2025a, Bai... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference6 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference7; FSCV from [Wallace2025a, Bai... -
3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference8 In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from 3CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference9; FSCV from [Wallace2025a, Bai... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference0 The availability of Cre-driver mouse lines and genetically encoded calcium indicators (GCaMPs) has enabled recording from genetically defined cell populations during behavior — a capability that has both refined and destabilized the canonical D1-MSN/D2-MSN framework introduced in{ref}sec-canonical-circuitry. Using fiber photometry calcium imaging in NAc, Calipari et al. (2016) defined D1-MSNs as the specific popu... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference1 The availability of Cre-driver mouse lines and genetically encoded calcium indicators (GCaMPs) has enabled recording from genetically defined cell populations during behavior — a capability that has both refined and destabilized the canonical D1-MSN/D2-MSN framework introduced in{ref}sec-canonical-circuitry. Using fiber photometry calcium imaging in NAc, Calipari et al. (2016) defined D1-MSNs as the specific popu... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference2 The availability of Cre-driver mouse lines and genetically encoded calcium indicators (GCaMPs) has enabled recording from genetically defined cell populations during behavior — a capability that has both refined and destabilized the canonical D1-MSN/D2-MSN framework introduced in{ref}sec-canonical-circuitry. Using fiber photometry calcium imaging in NAc, Calipari et al. (2016) defined D1-MSNs as the specific popu... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference3 The availability of Cre-driver mouse lines and genetically encoded calcium indicators (GCaMPs) has enabled recording from genetically defined cell populations during behavior — a capability that has both refined and destabilized the canonical D1-MSN/D2-MSN framework introduced in{ref}sec-canonical-circuitry. Using fiber photometry calcium imaging in NAc, Calipari et al. (2016) defined D1-MSNs as the specific popu... -
5CitationThe history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}
sec-dopamine-dynamics— is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...content/07_invivo_dynamics.md:line 9Open reference4 The availability of Cre-driver mouse lines and genetically encoded calcium indicators (GCaMPs) has enabled recording from genetically defined cell populations during behavior — a capability that has both refined and destabilized the canonical D1-MSN/D2-MSN framework introduced in{ref}sec-canonical-circuitry. Using fiber photometry calcium imaging in NAc, Calipari et al. (2016) defined D1-MSNs as the specific popu... -
... 100 additional anchors in refs_json
References
- [Lefevre2020] “The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}`sec-dopamine-dynamics` — is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...”
- [Pomrenze2025] “The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}`sec-dopamine-dynamics` — is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...”
- [Wallace2025a] “The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}`sec-dopamine-dynamics` — is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...”
- [Baird2023] “The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}`sec-dopamine-dynamics` — is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...”
- [Wallace2025b] “The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}`sec-dopamine-dynamics` — is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...”
- [Wallace2025c] “The history of dopamine (DA) measurement in addiction neuroscience — and its intimate connection to the theoretical frameworks evaluated in {ref}`sec-dopamine-dynamics` — is a history of successive technologies, each of which reframed the very phenomenon it purported to measure. Microdialysis, with temporal resolution on the order of minutes, established the foundational observation that drugs of abuse elevate extra...”
- [Liu2020a] “Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA *dips* during specific phases of drug-seeking that sustained-measurement approaches would integrate away [Liu2020a, Weber2025, Gyawali2023]. These are not simply high...”
- [Weber2025] “Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA *dips* during specific phases of drug-seeking that sustained-measurement approaches would integrate away [Liu2020a, Weber2025, Gyawali2023]. These are not simply high...”
- [Gyawali2023] “Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA *dips* during specific phases of drug-seeking that sustained-measurement approaches would integrate away [Liu2020a, Weber2025, Gyawali2023]. These are not simply high...”
- [Hu2023] “Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA *dips* during specific phases of drug-seeking that sustained-measurement approaches would integrate away [Liu2020a, Weber2025, Gyawali2023]. These are not simply high...”
- [Salinas2023] “Classical microdialysis reported sustained DA elevation during drug SA, establishing a framework of tonic DA increases. Genetically encoded sensors (dLight, GRAB-DA) instead reveal sub-second DA transients with complex temporal structure — including DA *dips* during specific phases of drug-seeking that sustained-measurement approaches would integrate away [Liu2020a, Weber2025, Gyawali2023]. These are not simply high...”
- [Molas2023] “The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors [Liu2020a, Weber2025, Gyawali2023, Molas2023]. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced...”
- [Bacharach2022] “The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors [Liu2020a, Weber2025, Gyawali2023, Molas2023]. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced...”
- [Bacharach2023] “The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors [Liu2020a, Weber2025, Gyawali2023, Molas2023]. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced...”
- [Bao2025] “The introduction of genetically encoded DA sensors — dLight and GRAB-DA — achieved sub-second temporal resolution comparable to FSCV while adding genetic targeting capability and the ability to record in freely moving animals during complex behaviors [Liu2020a, Weber2025, Gyawali2023, Molas2023]. Using dLight and GCaMP fiber photometry, Liu et al. (2020) demonstrated that SA and two forms of relapse (context-induced...”
- [Calipari2016] “In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from [Lefevre2020, Pomrenze2025]; FSCV from [Wallace2025a, Bai...”
- [Chalhoub2024] “In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from [Lefevre2020, Pomrenze2025]; FSCV from [Wallace2025a, Bai...”
- [Chen2025a] “In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from [Lefevre2020, Pomrenze2025]; FSCV from [Wallace2025a, Bai...”
- [Clarke2024] “In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from [Lefevre2020, Pomrenze2025]; FSCV from [Wallace2025a, Bai...”
- [Moorman2023] “In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from [Lefevre2020, Pomrenze2025]; FSCV from [Wallace2025a, Bai...”
- [Qiu2026] “In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from [Lefevre2020, Pomrenze2025]; FSCV from [Wallace2025a, Bai...”
- [Wingert2024] “In vivo recording technologies used in addiction neuroscience, comparing temporal resolution, spatial resolution, cell-type specificity, signal type, and key limitations. Panel A plots each method in resolution space; diamond markers indicate cell-type-specific technologies. Panel B summarizes signal properties and primary constraints. Microdialysis data from [Lefevre2020, Pomrenze2025]; FSCV from [Wallace2025a, Bai...”
- [ONeal2022] “The availability of Cre-driver mouse lines and genetically encoded calcium indicators (GCaMPs) has enabled recording from genetically defined cell populations during behavior — a capability that has both refined and destabilized the canonical D1-MSN/D2-MSN framework introduced in {ref}`sec-canonical-circuitry`. Using fiber photometry calcium imaging in NAc, Calipari et al. (2016) defined D1-MSNs as the specific popu...”
- [ONeal2021] “The availability of Cre-driver mouse lines and genetically encoded calcium indicators (GCaMPs) has enabled recording from genetically defined cell populations during behavior — a capability that has both refined and destabilized the canonical D1-MSN/D2-MSN framework introduced in {ref}`sec-canonical-circuitry`. Using fiber photometry calcium imaging in NAc, Calipari et al. (2016) defined D1-MSNs as the specific popu...”
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