Regional Diversity of Astrocytes
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Source: https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/content/11_regional_diversity.md
Citation anchors captured: 55
Citation contexts
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1CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference Section{ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the... -
2CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference Section{ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the... -
3CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference Section{ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the... -
4CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference Section{ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the... -
5CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference Section{ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the... -
6CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference Section{ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the... -
7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference Astrocyte Ca2+ signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...
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8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference Astrocyte Ca2+ signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...
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2CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference0 Astrocyte Ca2+ signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades 2CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference1, yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<... -
2CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference2 Astrocyte Ca2+ signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades 2CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference3, yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<... -
2CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference4 Astrocyte Ca2+ signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades 2CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference5, yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<... -
2CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference6 Astrocyte Ca2+ signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades 2CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference7, yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<... -
2CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference8 The supporting studies, however, report different quantities in different regions under different stimuli, and do not share a common axis. In dorsolateral striatum, Yu and colleagues attenuated astrocyte Ca2+ with AAV-delivered hPMCA2w/b and measured greater than 80% reduction of phenylephrine-evoked responses 2CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference9. In somatosensory cortex, Agarwal and colleagues reported that norepinephrine... -
3CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference0 The supporting studies, however, report different quantities in different regions under different stimuli, and do not share a common axis. In dorsolateral striatum, Yu and colleagues attenuated astrocyte Ca2+ with AAV-delivered hPMCA2w/b and measured greater than 80% reduction of phenylephrine-evoked responses 3CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference1. In somatosensory cortex, Agarwal and colleagues reported that norepinephrine... -
3CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference2 The supporting studies, however, report different quantities in different regions under different stimuli, and do not share a common axis. In dorsolateral striatum, Yu and colleagues attenuated astrocyte Ca2+ with AAV-delivered hPMCA2w/b and measured greater than 80% reduction of phenylephrine-evoked responses 3CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference3. In somatosensory cortex, Agarwal and colleagues reported that norepinephrine... -
3CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference4 The supporting studies, however, report different quantities in different regions under different stimuli, and do not share a common axis. In dorsolateral striatum, Yu and colleagues attenuated astrocyte Ca2+ with AAV-delivered hPMCA2w/b and measured greater than 80% reduction of phenylephrine-evoked responses 3CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference5. In somatosensory cortex, Agarwal and colleagues reported that norepinephrine... -
3CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference6 Figure{ref}fig:sec11-regional-ca-findingstherefore renders these four studies as a side-by-side summary rather than a shared-axis plot. Read that way, the four entries still support a coherent claim: the same molecular machinery (IP3R2, microdomain Ca2+ entry, Gq-driven elevation) yields measurably different baseline and evoked Ca2+ statistics in hippocampus, striatum, cortex, and cerebellu... -
3CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference7 Four within-study regional astrocyte Ca²⁺ findings shown side by side. Each row reports a different metric (event frequency, % attenuation, % NE-evoked change, Pearson R) in a different region and cell population, so no shared quantitative axis is implied; entries are summarised verbatim from 3CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference8. -
3CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference9 Four within-study regional astrocyte Ca²⁺ findings shown side by side. Each row reports a different metric (event frequency, % attenuation, % NE-evoked change, Pearson R) in a different region and cell population, so no shared quantitative axis is implied; entries are summarised verbatim from 4CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference0. -
4CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference1 Four within-study regional astrocyte Ca²⁺ findings shown side by side. Each row reports a different metric (event frequency, % attenuation, % NE-evoked change, Pearson R) in a different region and cell population, so no shared quantitative axis is implied; entries are summarised verbatim from 4CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference2. -
4CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference3 Four within-study regional astrocyte Ca²⁺ findings shown side by side. Each row reports a different metric (event frequency, % attenuation, % NE-evoked change, Pearson R) in a different region and cell population, so no shared quantitative axis is implied; entries are summarised verbatim from 4CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference4. -
4CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference5 Cortex is not a homogeneous astrocyte compartment. Lanjakornsiripan and colleagues performed a three-dimensional morphological and molecular characterisation across all layers of mouse somatosensory cortex and reported that neocortical astrocytes in layers II/III and layer VI display distinct territory sizes, process orientations, and marker expression 4CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference6. Bayraktar and colleagues then... -
4CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference7 Cortex is not a homogeneous astrocyte compartment. Lanjakornsiripan and colleagues performed a three-dimensional morphological and molecular characterisation across all layers of mouse somatosensory cortex and reported that neocortical astrocytes in layers II/III and layer VI display distinct territory sizes, process orientations, and marker expression 4CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference8. Bayraktar and colleagues then... -
4CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference9 Counting astrocyte “subtypes” across studies is harder than it looks. Single-cell and single-nucleus RNA-seq atlases have returned different numbers depending on regional scope, platform, and clustering resolution: Batiuk and colleagues resolved five transcriptomically distinct astrocyte subtypes in adult mouse cortex and hippocampus 5CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference0; the Zeisel mouse-nervous-system atlas reported seven regio... -
5CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference1 Counting astrocyte “subtypes” across studies is harder than it looks. Single-cell and single-nucleus RNA-seq atlases have returned different numbers depending on regional scope, platform, and clustering resolution: Batiuk and colleagues resolved five transcriptomically distinct astrocyte subtypes in adult mouse cortex and hippocampus 5CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference2; the Zeisel mouse-nervous-system atlas reported seven regio... -
5CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference3 Counting astrocyte “subtypes” across studies is harder than it looks. Single-cell and single-nucleus RNA-seq atlases have returned different numbers depending on regional scope, platform, and clustering resolution: Batiuk and colleagues resolved five transcriptomically distinct astrocyte subtypes in adult mouse cortex and hippocampus 5CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference4; the Zeisel mouse-nervous-system atlas reported seven regio... -
5CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference5 Figure{ref}fig:sec11-subtype-countsgroups the comparable studies by method for this reason, and deliberately omits two entries that entered earlier versions of the comparison but do not report astrocyte-subtype counts. Saunders and colleagues described 565 transcriptionally distinct cell groups across nine brain regions, but that total aggregates all cell types in nine regions, not astrocyte types [saunders_2018... -
5CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference6 Figure{ref}fig:sec11-subtype-countsgroups the comparable studies by method for this reason, and deliberately omits two entries that entered earlier versions of the comparison but do not report astrocyte-subtype counts. Saunders and colleagues described 565 transcriptionally distinct cell groups across nine brain regions, but that total aggregates all cell types in nine regions, not astrocyte types [saunders_2018... -
5CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference7 Reported astrocyte subtype counts split by method. Transcriptomic clusters from 5CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference8 (panel a) and spatial-layer identities from 5CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference9 (panel b) measure different axes of diversity; counts depend on regional scope and clustering resolution and are not directly commensurable. -
6CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference0 Reported astrocyte subtype counts split by method. Transcriptomic clusters from 6CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference1 (panel a) and spatial-layer identities from 6CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference2 (panel b) measure different axes of diversity; counts depend on regional scope and clustering resolution and are not directly commensurable. -
6CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference3 Reported astrocyte subtype counts split by method. Transcriptomic clusters from 6CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference4 (panel a) and spatial-layer identities from 6CitationSection {ref}sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference5 (panel b) measure different axes of diversity; counts depend on regional scope and clustering resolution and are not directly commensurable. -
6CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference6 Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see sec-synaptic-modulation). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab... -
6CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference7 Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see sec-synaptic-modulation). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab... -
6CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference8 Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see sec-synaptic-modulation). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab... -
6CitationSection {ref}
sec:oscillationsleft a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...content/11_regional_diversity.md:line 4Open reference9 Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see sec-synaptic-modulation). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab... -
7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference0 Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see sec-synaptic-modulation). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab...
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference1 Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see sec-synaptic-modulation). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab...
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference2 Because only two entries anchor this comparison directly, and because both report qualitative regional distributions rather than quantified concentrations, Figure
{ref}fig:sec11-glt1-glast-regionalrenders the result as a qualitative regional map rather than a numeric plot. What the data demonstrate is a regional asymmetry of transporter complement, not a calibrated regional gradient: forebrain regions (cortex, hi... -
7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference3 Because only two entries anchor this comparison directly, and because both report qualitative regional distributions rather than quantified concentrations, Figure
{ref}fig:sec11-glt1-glast-regionalrenders the result as a qualitative regional map rather than a numeric plot. What the data demonstrate is a regional asymmetry of transporter complement, not a calibrated regional gradient: forebrain regions (cortex, hi... -
7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference4 Qualitative regional distribution of astrocyte glutamate transporters GLT-1 (EAAT2) and GLAST (EAAT1), summarised from abstract-level extractions of 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference5. Cells marked “not described” are absent from the source entries rather than inferred. The figure renders categorical levels, not calibrated concentrations.
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference6 Qualitative regional distribution of astrocyte glutamate transporters GLT-1 (EAAT2) and GLAST (EAAT1), summarised from abstract-level extractions of 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference7. Cells marked “not described” are absent from the source entries rather than inferred. The figure renders categorical levels, not calibrated concentrations.
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference8 The best-known conflict in the astrocyte literature — whether Ca2+-driven gliotransmission is a general modulator of synaptic physiology — looks different once regional specificity is taken seriously. In hippocampal CA1, Petravicz and colleagues reported that deletion of IP3R2, which blocks GPCR/IP3-driven astrocyte Ca2+ rises, has no measurable effect on baseline excitatory synaptic activity [...
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference9 The best-known conflict in the astrocyte literature — whether Ca2+-driven gliotransmission is a general modulator of synaptic physiology — looks different once regional specificity is taken seriously. In hippocampal CA1, Petravicz and colleagues reported that deletion of IP3R2, which blocks GPCR/IP3-driven astrocyte Ca2+ rises, has no measurable effect on baseline excitatory synaptic activity [...
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference0 The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference1 against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference2. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca2+ persists and is large in am...
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference3 The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference4 against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference5. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca2+ persists and is large in am...
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference6 The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference7 against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission 7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference8. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca2+ persists and is large in am...
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7CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference, 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference9 The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference0 against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference1. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca2+ persists and is large in am...
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8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference2 The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference3 against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference4. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca2+ persists and is large in am...
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8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference5 One structural point follows directly from the quantitative Ca2+ and transcriptomic surveys above. The same Ca2+ machinery interrogated with the same tools yields different basal statistics in different regions 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference6, and the downstream transporter complement that shapes the synaptic glutamate transient is itself region-asymmet...
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8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference7 One structural point follows directly from the quantitative Ca2+ and transcriptomic surveys above. The same Ca2+ machinery interrogated with the same tools yields different basal statistics in different regions 8CitationAstrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti1997jneurosci,halassa2010annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...content/11_regional_diversity.md:line 8Open reference8, and the downstream transporter complement that shapes the synaptic glutamate transient is itself region-asymmet...
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References
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- [khakh_2019_annurevneurosci] “Section {ref}`sec:oscillations` left a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...”
- [verkhratsky_2018_physiological] “Section {ref}`sec:oscillations` left a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...”
- [oberheim_2009_jneurosci] “Section {ref}`sec:oscillations` left a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...”
- [zhang_2014_jneurosci] “Section {ref}`sec:oscillations` left a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...”
- [boisvert_2018_cellreports] “Section {ref}`sec:oscillations` left a loose end: astrocytic contributions to cortical rhythms did not generalise cleanly across studies, and part of the variance tracked the brain region that was recorded rather than the rhythm itself. That observation motivates a formal inventory. If hippocampal CA1 slice physiology is the modal experimental preparation in the astrocyte literature, the question is how much of the...”
- [pasti_1997_jneurosci] “Astrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti_1997_jneurosci,halassa_2010_annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...”
- [halassa_2010_annurev] “Astrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti_1997_jneurosci,halassa_2010_annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...”
- [chai_2017_neuron] “Astrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti_1997_jneurosci,halassa_2010_annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...”
- [yu_2018_neuron] “Astrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti_1997_jneurosci,halassa_2010_annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...”
- [agarwal_2017_neuron] “Astrocyte Ca<sup>2+</sup> signalling was described in the cerebral cortex and hippocampus with near-identical vocabulary for two decades [pasti_1997_jneurosci,halassa_2010_annurev], yet quantitative cross-region comparisons paint a less uniform picture. Chai and colleagues imaged GCaMP6 in dorsolateral striatum and hippocampal CA1 stratum radiatum from the same experimental pipeline and reported that spontaneous Ca<...”
- [paukert_2014_neuron] “The supporting studies, however, report different quantities in different regions under different stimuli, and do not share a common axis. In dorsolateral striatum, Yu and colleagues attenuated astrocyte Ca<sup>2+</sup> with AAV-delivered hPMCA2w/b and measured greater than 80\% reduction of phenylephrine-evoked responses [yu_2018_neuron]. In somatosensory cortex, Agarwal and colleagues reported that norepinephrine...”
- [shigetomi_2012_natneurosci] “The supporting studies, however, report different quantities in different regions under different stimuli, and do not share a common axis. In dorsolateral striatum, Yu and colleagues attenuated astrocyte Ca<sup>2+</sup> with AAV-delivered hPMCA2w/b and measured greater than 80\% reduction of phenylephrine-evoked responses [yu_2018_neuron]. In somatosensory cortex, Agarwal and colleagues reported that norepinephrine...”
- [shigetomi_2013_neuroscience] “Figure {ref}`fig:sec11-regional-ca-findings` therefore renders these four studies as a side-by-side summary rather than a shared-axis plot. Read that way, the four entries still support a coherent claim: the same molecular machinery (IP3R2, microdomain Ca<sup>2+</sup> entry, Gq-driven elevation) yields measurably different baseline and evoked Ca<sup>2+</sup> statistics in hippocampus, striatum, cortex, and cerebellu...”
- [lanjakornsiripan_2018_natcommun] “Cortex is not a homogeneous astrocyte compartment. Lanjakornsiripan and colleagues performed a three-dimensional morphological and molecular characterisation across all layers of mouse somatosensory cortex and reported that neocortical astrocytes in layers II/III and layer VI display distinct territory sizes, process orientations, and marker expression [lanjakornsiripan_2018_natcommun]. Bayraktar and colleagues then...”
- [bayraktar_2020_natneurosci] “Cortex is not a homogeneous astrocyte compartment. Lanjakornsiripan and colleagues performed a three-dimensional morphological and molecular characterisation across all layers of mouse somatosensory cortex and reported that neocortical astrocytes in layers II/III and layer VI display distinct territory sizes, process orientations, and marker expression [lanjakornsiripan_2018_natcommun]. Bayraktar and colleagues then...”
- [batiuk_2020_natcommun] “Counting astrocyte "subtypes" across studies is harder than it looks. Single-cell and single-nucleus RNA-seq atlases have returned different numbers depending on regional scope, platform, and clustering resolution: Batiuk and colleagues resolved five transcriptomically distinct astrocyte subtypes in adult mouse cortex and hippocampus [batiuk_2020_natcommun]; the Zeisel mouse-nervous-system atlas reported seven regio...”
- [zeisel_2018_cell] “Counting astrocyte "subtypes" across studies is harder than it looks. Single-cell and single-nucleus RNA-seq atlases have returned different numbers depending on regional scope, platform, and clustering resolution: Batiuk and colleagues resolved five transcriptomically distinct astrocyte subtypes in adult mouse cortex and hippocampus [batiuk_2020_natcommun]; the Zeisel mouse-nervous-system atlas reported seven regio...”
- [saunders_2018_cell] “Figure {ref}`fig:sec11-subtype-counts` groups the comparable studies by method for this reason, and deliberately omits two entries that entered earlier versions of the comparison but do not report astrocyte-subtype counts. Saunders and colleagues described 565 transcriptionally distinct cell groups across nine brain regions, but that total aggregates all cell types in nine regions, not astrocyte types [saunders_2018...”
- [storck_1992_procnatl] “Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see *sec-synaptic-modulation*). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab...”
- [rothstein_1994_neuron] “Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see *sec-synaptic-modulation*). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab...”
- [lehre_1995_jneurosci] “Regional asymmetry is clearest for glutamate transporters. GLT-1 (EAAT2) and GLAST (EAAT1) are the two high-capacity astrocyte glutamate transporters that set the spatial extent and kinetics of the tripartite synapse (see *sec-synaptic-modulation*). Storck and colleagues first cloned GLAST and reported by in situ hybridisation a strikingly high density of GLAST mRNA in the Purkinje cell layer of cerebellum, presumab...”
- [petravicz_2008_jneurosci] “The best-known conflict in the astrocyte literature — whether Ca<sup>2+</sup>-driven gliotransmission is a general modulator of synaptic physiology — looks different once regional specificity is taken seriously. In hippocampal CA1, Petravicz and colleagues reported that deletion of IP3R2, which blocks GPCR/IP3-driven astrocyte Ca<sup>2+</sup> rises, has no measurable effect on baseline excitatory synaptic activity [...”
- [lalo_2014_plosbiol] “The best-known conflict in the astrocyte literature — whether Ca<sup>2+</sup>-driven gliotransmission is a general modulator of synaptic physiology — looks different once regional specificity is taken seriously. In hippocampal CA1, Petravicz and colleagues reported that deletion of IP3R2, which blocks GPCR/IP3-driven astrocyte Ca<sup>2+</sup> rises, has no measurable effect on baseline excitatory synaptic activity [...”
- [agulhon_2008_neuron] “The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments [agulhon_2008_neuron] against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission [araque_2014_neuron]. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca<sup>2+</sup> persists and is large in am...”
- [araque_2014_neuron] “The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments [agulhon_2008_neuron] against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission [araque_2014_neuron]. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca<sup>2+</sup> persists and is large in am...”
- [savtchouk_2018_jneurosci] “The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments [agulhon_2008_neuron] against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission [araque_2014_neuron]. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca<sup>2+</sup> persists and is large in am...”
- [araque_2017_neuropharmacology] “The broader debate has been framed as Agulhon/McCarthy-camp negative results from IP3R2 knockout and Gq-DREADD experiments [agulhon_2008_neuron] against Araque/Navarrete-camp positive results from acute manipulations and endocannabinoid-driven gliotransmission [araque_2014_neuron]. A partial reconciliation has emerged with the recognition that IP3R2-independent microdomain Ca<sup>2+</sup> persists and is large in am...”
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