Molecular Identity and Transcriptomic Taxonomy

Molecular Identity and Transcriptomic Taxonomy

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Source: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/content/02_molecular_identity.md

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• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference} Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference} Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference} Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference} Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference} Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4 Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...

• ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6 The molecular identity of PV-INs was assembled through convergent evidence from immunohistochemistry, transcriptional profiling, and functional genomics. A computational genomic screen of physiologically characterized cortical GABAergic neurons identified approximately 40 gene families across six functional categories distinguishing cardinal interneuron types ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7. Fast-spiking PV basket cells e...

• ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8 The molecular identity of PV-INs was assembled through convergent evidence from immunohistochemistry, transcriptional profiling, and functional genomics. A computational genomic screen of physiologically characterized cortical GABAergic neurons identified approximately 40 gene families across six functional categories distinguishing cardinal interneuron types ^{2Citationpaper:paper-5448749b4033Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9. Fast-spiking PV basket cells e...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0 The molecular identity of PV-INs was assembled through convergent evidence from immunohistochemistry, transcriptional profiling, and functional genomics. A computational genomic screen of physiologically characterized cortical GABAergic neurons identified approximately 40 gene families across six functional categories distinguishing cardinal interneuron types ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1. Fast-spiking PV basket cells e...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2 The molecular identity of PV-INs was assembled through convergent evidence from immunohistochemistry, transcriptional profiling, and functional genomics. A computational genomic screen of physiologically characterized cortical GABAergic neurons identified approximately 40 gene families across six functional categories distinguishing cardinal interneuron types ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3. Fast-spiking PV basket cells e...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8 Beyond ion channels, ErbB4 has emerged as a molecular hallmark with functional consequences for PV-IN connectivity and disease relevance. ErbB4 is preferentially expressed by the majority of PV-INs and mediates neuregulin-1 (NRG1) signaling that promotes excitatory synapse development specifically on GABAergic interneurons ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9. ErbB4 plays functionally distinct...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1. Seven met-types corresponded to...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3. Seven met-types corresponded to...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5. Seven met-types corresponded to...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7. Seven met-types corresponded to...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9. Seven met-types corresponded to...

• ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1. Seven met-types corresponded to...

• ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3. Seven met-types corresponded to...

• ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5. Seven met-types corresponded to...

• ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6 The first comprehensive multimodal atlas characterized over 4,200 mouse visual cortical GABAergic interneurons using Patch-seq (combined transcriptomic and electrophysiological profiling), with morphological reconstruction of 517 neurons, defining 28 multimodal types (met-types) with congruent morphological, electrophysiological, and transcriptomic properties ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7. Seven met-types corresponded to...

• ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{3Citationpaper:paper-560189f9d2b5Parvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0. Morphological reconstruction of neurons with...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3. Morphological reconstruction of neurons with...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6. Morphological reconstruction of neurons with...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9. Morphological reconstruction of neurons with...

• ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2. Morphological reconstruction of neurons with...

• ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5. Morphological reconstruction of neurons with...

• ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8. Morphological reconstruction of neurons with...

• ^{4Citationpaper:paper-35a6c66c3e2eParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9 Orthogonal profiling modalities have reinforced these transcriptomic architectures. Single-nucleus DNA methylome sequencing identified cell-type-specific methylation signatures corroborating transcriptomic classifications ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}0, and transcription factors emerged as major determinants of cell type identity in comprehensive atlases ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}1. Morphological reconstruction of neurons with...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}2 Scaling of single-cell transcriptomic atlases resolving PV interneuron diversity. Cell counts and PV subtype resolution across three landmark mouse atlases: Patch-seq multimodal profiling of visual cortex (>4,200 cells; 7 PV met-types) ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}3, isocortex-wide scRNA-seq (~1.3 million cells; 3 Pvalb supertypes) ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}4, and whole-brain atlas (~7 million scRNA-seq + ~4.3 million MERFISH ce...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}5 Scaling of single-cell transcriptomic atlases resolving PV interneuron diversity. Cell counts and PV subtype resolution across three landmark mouse atlases: Patch-seq multimodal profiling of visual cortex (>4,200 cells; 7 PV met-types) ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}6, isocortex-wide scRNA-seq (~1.3 million cells; 3 Pvalb supertypes) ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}7, and whole-brain atlas (~7 million scRNA-seq + ~4.3 million MERFISH ce...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}8 Scaling of single-cell transcriptomic atlases resolving PV interneuron diversity. Cell counts and PV subtype resolution across three landmark mouse atlases: Patch-seq multimodal profiling of visual cortex (>4,200 cells; 7 PV met-types) ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}9, isocortex-wide scRNA-seq (~1.3 million cells; 3 Pvalb supertypes) ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}00, and whole-brain atlas (~7 million scRNA-seq + ~4.3 million MERFISH ce...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}01 Discrete vs. continuous PV transcriptomic variation (C01). Multimodal profiling of mouse visual cortex identified seven discrete PV met-types with robust cross-modal predictability ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}02. In contrast, morphology-guided scRNA-seq of hippocampal PV-INs found high transcriptomic similarity across morphologically distinct subtypes, with few divergent genes and a uniform synaptic cell adhesion molec...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}03 Discrete vs. continuous PV transcriptomic variation (C01). Multimodal profiling of mouse visual cortex identified seven discrete PV met-types with robust cross-modal predictability ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}04. In contrast, morphology-guided scRNA-seq of hippocampal PV-INs found high transcriptomic similarity across morphologically distinct subtypes, with few divergent genes and a uniform synaptic cell adhesion molec...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}05 Discrete vs. continuous PV transcriptomic variation (C01). Multimodal profiling of mouse visual cortex identified seven discrete PV met-types with robust cross-modal predictability ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}06. In contrast, morphology-guided scRNA-seq of hippocampal PV-INs found high transcriptomic similarity across morphologically distinct subtypes, with few divergent genes and a uniform synaptic cell adhesion molec...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}07 The strongest evidence for discrete PV types comes from the multimodal atlas, where integration across modalities in the same cells revealed mutually predictable met-types ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}08. The chandelier cell identity emerged as a robustly discrete type marked by Pvalb Vipr2 transcriptomic signature and confirmed by morphological reconstruction ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}09. Different Pvalb tran...

• ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}10 The strongest evidence for discrete PV types comes from the multimodal atlas, where integration across modalities in the same cells revealed mutually predictable met-types ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}11. The chandelier cell identity emerged as a robustly discrete type marked by Pvalb Vipr2 transcriptomic signature and confirmed by morphological reconstruction ^{1Citationpaper:paper-53c8505de50fParvalbumin-expressing (PV+) interneurons constitute the largest subpopulation of cortical GABAergic neurons, comprising approximately 40% of the inhibitory cell complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal peptide-expressing (VIP+) cells, they account for nearly the entirety of cortical GABAergic neurons, though a fourth Id2-expressing group has recently...content/02_molecular_identity.md:line 4Open reference}12. Different Pvalb tran...

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