Hippocampal SST Interneurons
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1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference The preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference Hippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference but diverge sharply in... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference Hippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference but diverge sharply in... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference Hippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference but diverge sharply in... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference0 The defining feature that distinguishes hippocampal SST subtypes from one another — and from their neocortical counterparts — is the precision of their dendritic domain targeting ({ref}sec-morphological-diversity). Electron microscopy studies established that SST-immunoreactive axon terminals in the rat hippocampus preferentially contact dendrites of pyramidal cells, with approximately 76% of postsynaptic targets... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference1 O-LM cells, with somata in stratum oriens and axons ascending to stratum lacunosum-moleculare, selectively inhibit the distal dendritic tufts where entorhinal cortex inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference2. Bistratified cells, by contrast, ramify their axons across strata radiatum and oriens, targeting the proximal and basal dendritic domains that receive Schaffer collateral input from CA3 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference3. Th... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference4 O-LM cells, with somata in stratum oriens and axons ascending to stratum lacunosum-moleculare, selectively inhibit the distal dendritic tufts where entorhinal cortex inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference5. Bistratified cells, by contrast, ramify their axons across strata radiatum and oriens, targeting the proximal and basal dendritic domains that receive Schaffer collateral input from CA3 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference6. Th... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference7 O-LM cells, with somata in stratum oriens and axons ascending to stratum lacunosum-moleculare, selectively inhibit the distal dendritic tufts where entorhinal cortex inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference8. Bistratified cells, by contrast, ramify their axons across strata radiatum and oriens, targeting the proximal and basal dendritic domains that receive Schaffer collateral input from CA3 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference9. Th... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0 O-LM cells, with somata in stratum oriens and axons ascending to stratum lacunosum-moleculare, selectively inhibit the distal dendritic tufts where entorhinal cortex inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1. Bistratified cells, by contrast, ramify their axons across strata radiatum and oriens, targeting the proximal and basal dendritic domains that receive Schaffer collateral input from CA3 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2. Th... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3 O-LM cells, with somata in stratum oriens and axons ascending to stratum lacunosum-moleculare, selectively inhibit the distal dendritic tufts where entorhinal cortex inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4. Bistratified cells, by contrast, ramify their axons across strata radiatum and oriens, targeting the proximal and basal dendritic domains that receive Schaffer collateral input from CA3 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5. Th... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6 Recent work using intersectional genetic strategies has refined this picture further. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7 employed Sst;;Tac1 and Ndnf;;Nkx2-1 intersectional lines in mouse CA1 to dissect SST interneuron subtypes with unprecedented specificity. Sst;;Tac1 bistratified interneurons generated 85% of the inhibitory postsynaptic currents (IPSCs) recorded in CA1 pyramidal cells upon optogenetic stimulation of the general SST... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8 Recent work using intersectional genetic strategies has refined this picture further. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9 employed Sst;;Tac1 and Ndnf;;Nkx2-1 intersectional lines in mouse CA1 to dissect SST interneuron subtypes with unprecedented specificity. Sst;;Tac1 bistratified interneurons generated 85% of the inhibitory postsynaptic currents (IPSCs) recorded in CA1 pyramidal cells upon optogenetic stimulation of the general SST... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0 Complementing these cell-type-specific studies, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1 characterized the synaptic and dendritic architecture across hippocampal SST subtypes, estimating that an individual hippocampal SST interneuron receives approximately 15,600 synaptic inputs, of which roughly 16% are GABAergic 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2. The input pathway selectivity of O-LM cells was further dissected by 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3, who found that the medial entorhinal...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4 Complementing these cell-type-specific studies, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5 characterized the synaptic and dendritic architecture across hippocampal SST subtypes, estimating that an individual hippocampal SST interneuron receives approximately 15,600 synaptic inputs, of which roughly 16% are GABAergic 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6. The input pathway selectivity of O-LM cells was further dissected by 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7, who found that the medial entorhinal...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8 Complementing these cell-type-specific studies, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9 characterized the synaptic and dendritic architecture across hippocampal SST subtypes, estimating that an individual hippocampal SST interneuron receives approximately 15,600 synaptic inputs, of which roughly 16% are GABAergic 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0. The input pathway selectivity of O-LM cells was further dissected by 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1, who found that the medial entorhinal...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2 Complementing these cell-type-specific studies, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3 characterized the synaptic and dendritic architecture across hippocampal SST subtypes, estimating that an individual hippocampal SST interneuron receives approximately 15,600 synaptic inputs, of which roughly 16% are GABAergic 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4. The input pathway selectivity of O-LM cells was further dissected by 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5, who found that the medial entorhinal...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6 In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7. 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8 demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9 In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1 demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2 In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4 demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5 In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7 demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8 In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9. 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0 demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1 The most striking functional distinction between hippocampal SST subtypes emerges during network oscillations. The landmark juxtacellular recording studies of Klausberger, Somogyi, and colleagues established that O-LM and bistratified cells fire at distinct phases of the theta rhythm and show opposing modulation during sharp-wave ripples (SWRs) 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2. This work, conducted primarily in anesthetized and head-...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3 The precise theta phase at which O-LM cells fire is reported inconsistently across studies. it has been reported O-LM cells firing preferentially at the trough of theta recorded in stratum pyramidale, with suppression during SWRs — a pattern independently confirmed by 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4 using juxtacellular recordings of identified dendrite-targeting interneurons in rat CA1. However, it was found that the behavioral stat...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5 The divergent oscillatory profiles of O-LM and bistratified cells are summarized in
{numref}fig-sec9-olm-vs-bistratified. During theta oscillations, both subtypes are phase-locked but with different preferred phases and coupling strengths 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6. The most dramatic divergence occurs during SWRs: it has been shown that during hippocampal network state transitions from theta to sharp-wave ripple, inhibition i... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7 Qualitative comparison of O-LM and bistratified cell activity across hippocampal network states and oscillation coupling profiles. (a) Relative firing rates during theta oscillations, sharp-wave ripples, and quiet wakefulness/sleep, synthesized from juxtacellular recording studies in rat CA1. (b) Coupling strength to theta, slow gamma, fast gamma, and SWR events 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8. Metric definitions vary...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9 Qualitative comparison of O-LM and bistratified cell activity across hippocampal network states and oscillation coupling profiles. (a) Relative firing rates during theta oscillations, sharp-wave ripples, and quiet wakefulness/sleep, synthesized from juxtacellular recording studies in rat CA1. (b) Coupling strength to theta, slow gamma, fast gamma, and SWR events 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0. Metric definitions vary...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2 extended this picture to gamma-frequency oscillations, demonstrating layer-specific GABAergic control of distinct gamma oscillations in CA1: SST+ dendrite-targeting cells contributed to slow gamma while PV+ perisomatic-targeting cells drove fast gamma 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3. This frequency-band segregation between subtypes has computational implications explored in
{ref}sec-oscillatory-dynamics. Computati... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5 extended this picture to gamma-frequency oscillations, demonstrating layer-specific GABAergic control of distinct gamma oscillations in CA1: SST+ dendrite-targeting cells contributed to slow gamma while PV+ perisomatic-targeting cells drove fast gamma 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6. This frequency-band segregation between subtypes has computational implications explored in
{ref}sec-oscillatory-dynamics. Computati... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7 The laminar specificity of hippocampal SST subtypes positions them as potential gatekeepers of information flow between hippocampal subregions. Computational models first proposed this idea: 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8 modeled the CA1 microcircuit and found that O-LM cell activation favors retrieval by suppressing entorhinal cortex input to distal dendrites while allowing CA3-driven recall through proximal dendrites [Cutsuridi...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9 The laminar specificity of hippocampal SST subtypes positions them as potential gatekeepers of information flow between hippocampal subregions. Computational models first proposed this idea: 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0 modeled the CA1 microcircuit and found that O-LM cell activation favors retrieval by suppressing entorhinal cortex input to distal dendrites while allowing CA3-driven recall through proximal dendrites [Cutsuridi... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1 The laminar specificity of hippocampal SST subtypes positions them as potential gatekeepers of information flow between hippocampal subregions. Computational models first proposed this idea: 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2 modeled the CA1 microcircuit and found that O-LM cell activation favors retrieval by suppressing entorhinal cortex input to distal dendrites while allowing CA3-driven recall through proximal dendrites [Cutsuridi... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3 The laminar specificity of hippocampal SST subtypes positions them as potential gatekeepers of information flow between hippocampal subregions. Computational models first proposed this idea: 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4 modeled the CA1 microcircuit and found that O-LM cell activation favors retrieval by suppressing entorhinal cortex input to distal dendrites while allowing CA3-driven recall through proximal dendrites [Cutsuridi... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5 The gating function extends beyond the hippocampal formation proper. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6 showed that discrete hippocampal output projections are differentially regulated by PV and SST interneurons, with SST interneuron activity selectively modulating specific projection pathways 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8 demonstrated that frontal cortex SST interneurons gate hippocampal inputs in a learning-dependent manner, revealing cross-... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference, 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9 The gating function extends beyond the hippocampal formation proper. 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference0 showed that discrete hippocampal output projections are differentially regulated by PV and SST interneurons, with SST interneuron activity selectively modulating specific projection pathways 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference1. 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference2 demonstrated that frontal cortex SST interneurons gate hippocampal inputs in a learning-dependent manner, revealing cross-... -
2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference3 The gating function extends beyond the hippocampal formation proper. 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference4 showed that discrete hippocampal output projections are differentially regulated by PV and SST interneurons, with SST interneuron activity selectively modulating specific projection pathways 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference5. 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference6 demonstrated that frontal cortex SST interneurons gate hippocampal inputs in a learning-dependent manner, revealing cross-...
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2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference7 The gating function extends beyond the hippocampal formation proper. 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference8 showed that discrete hippocampal output projections are differentially regulated by PV and SST interneurons, with SST interneuron activity selectively modulating specific projection pathways 2CitationHippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...content/09_hippocampal_sst.md:line 5Open reference9. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference00 demonstrated that frontal cortex SST interneurons gate hippocampal inputs in a learning-dependent manner, revealing cross-... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference01 The most robust evidence for hippocampal SST function in behavior comes from memory paradigms. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference02 demonstrated that aversive stimuli activate CA1 dendrite-targeting (SOM+) interneurons via cholinergic input, leading to inhibition of pyramidal cell distal dendrites receiving aversive sensory excitation from the entorhinal cortex 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference03. Inactivating these dendrite-targeting interneurons du... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference04 The most robust evidence for hippocampal SST function in behavior comes from memory paradigms. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference05 demonstrated that aversive stimuli activate CA1 dendrite-targeting (SOM+) interneurons via cholinergic input, leading to inhibition of pyramidal cell distal dendrites receiving aversive sensory excitation from the entorhinal cortex 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference06. Inactivating these dendrite-targeting interneurons du... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference07 Subsequent studies expanded the behavioral repertoire. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference08 showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference09. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference10 Subsequent studies expanded the behavioral repertoire. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference11 showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference12. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference13 Subsequent studies expanded the behavioral repertoire. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference14 showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference15. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference16 Subsequent studies expanded the behavioral repertoire. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference17 showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference18. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference19 Subsequent studies expanded the behavioral repertoire. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference20 showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference21. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference22 Subsequent studies expanded the behavioral repertoire. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference23 showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference24. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference25 The relationship between SST inhibition and memory recall, however, introduces apparent paradoxes. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference26 demonstrated that when fear was associated with inhibition of hippocampal SST interneurons, re-inhibition of the same interneurons could recall fear memory — suggesting that the pattern of SST activity during encoding becomes part of the memory trace itself, and reactivating that pattern is sufficient for r... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference27 The relationship between SST inhibition and memory recall, however, introduces apparent paradoxes. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference28 demonstrated that when fear was associated with inhibition of hippocampal SST interneurons, re-inhibition of the same interneurons could recall fear memory — suggesting that the pattern of SST activity during encoding becomes part of the memory trace itself, and reactivating that pattern is sufficient for r... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference29 The relationship between SST inhibition and memory recall, however, introduces apparent paradoxes. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference30 demonstrated that when fear was associated with inhibition of hippocampal SST interneurons, re-inhibition of the same interneurons could recall fear memory — suggesting that the pattern of SST activity during encoding becomes part of the memory trace itself, and reactivating that pattern is sufficient for r... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference31 The relationship between SST inhibition and memory recall, however, introduces apparent paradoxes. 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference32 demonstrated that when fear was associated with inhibition of hippocampal SST interneurons, re-inhibition of the same interneurons could recall fear memory — suggesting that the pattern of SST activity during encoding becomes part of the memory trace itself, and reactivating that pattern is sufficient for r... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference33 Effects of hippocampal SST interneuron manipulation on memory across five studies employing different behavioral paradigms and manipulation methods 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference34. Direction indicates qualitative effect (impairment versus enhancement); magnitude is not comparable across studies. Marker shape and color encode replication status: diamond (independently replicated... -
1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}
sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference35 Effects of hippocampal SST interneuron manipulation on memory across five studies employing different behavioral paradigms and manipulation methods 1CitationThe preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}sec-synaptic-connectivity). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...content/09_hippocampal_sst.md:line 3Open reference36. Direction indicates qualitative effect (impairment versus enhancement); magnitude is not comparable across studies. Marker shape and color encode replication status: diamond (independently replicated... -
... 87 additional anchors in refs_json
References
- [Pelkey2017] “The preceding sections established that neocortical SST interneurons operate within a feedforward and feedback cortical architecture, where Martinotti cells provide dendritic inhibition to pyramidal neurons across layers ({ref}`sec-synaptic-connectivity`). The hippocampal formation, however, presents a fundamentally different circuit organization — a trisynaptic loop with laminated inputs arriving at distinct dendri...”
- [Tricoire2011] “Hippocampal SST interneurons encompass several morphologically and functionally distinct populations, most prominently oriens-lacunosum moleculare (O-LM) cells, bistratified cells, and hilar perforant path-associated (HIPP) cells in the dentate gyrus [Pelkey2017, Tricoire2011]. These subtypes share somatostatin expression and medial ganglionic eminence (MGE) developmental origin [Tricoire2011] but diverge sharply in...”
- [Katona1999] “The defining feature that distinguishes hippocampal SST subtypes from one another — and from their neocortical counterparts — is the precision of their dendritic domain targeting ({ref}`sec-morphological-diversity`). Electron microscopy studies established that SST-immunoreactive axon terminals in the rat hippocampus preferentially contact dendrites of pyramidal cells, with approximately 76% of postsynaptic targets...”
- [MAller2014] “O-LM cells, with somata in stratum oriens and axons ascending to stratum lacunosum-moleculare, selectively inhibit the distal dendritic tufts where entorhinal cortex inputs arrive [MAller2014, Pelkey2017]. Bistratified cells, by contrast, ramify their axons across strata radiatum and oriens, targeting the proximal and basal dendritic domains that receive Schaffer collateral input from CA3 [MAller2014, Baude2007]. Th...”
- [Baude2007] “O-LM cells, with somata in stratum oriens and axons ascending to stratum lacunosum-moleculare, selectively inhibit the distal dendritic tufts where entorhinal cortex inputs arrive [MAller2014, Pelkey2017]. Bistratified cells, by contrast, ramify their axons across strata radiatum and oriens, targeting the proximal and basal dendritic domains that receive Schaffer collateral input from CA3 [MAller2014, Baude2007]. Th...”
- [Chamberland2024] “Recent work using intersectional genetic strategies has refined this picture further. [Chamberland2024] employed Sst;;Tac1 and Ndnf;;Nkx2-1 intersectional lines in mouse CA1 to dissect SST interneuron subtypes with unprecedented specificity. Sst;;Tac1 bistratified interneurons generated 85% of the inhibitory postsynaptic currents (IPSCs) recorded in CA1 pyramidal cells upon optogenetic stimulation of the general SST...”
- [Takacs2024] “Complementing these cell-type-specific studies, [Takacs2024] characterized the synaptic and dendritic architecture across hippocampal SST subtypes, estimating that an individual hippocampal SST interneuron receives approximately 15,600 synaptic inputs, of which roughly 16% are GABAergic [Takacs2024]. The input pathway selectivity of O-LM cells was further dissected by [Bell2021], who found that the medial entorhinal...”
- [Bell2021] “Complementing these cell-type-specific studies, [Takacs2024] characterized the synaptic and dendritic architecture across hippocampal SST subtypes, estimating that an individual hippocampal SST interneuron receives approximately 15,600 synaptic inputs, of which roughly 16% are GABAergic [Takacs2024]. The input pathway selectivity of O-LM cells was further dissected by [Bell2021], who found that the medial entorhinal...”
- [Savanthrapadian2014] “In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive [Savanthrapadian2014, Raven2025b]. [Savanthrapadian2014] demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino...”
- [Raven2025b] “In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive [Savanthrapadian2014, Raven2025b]. [Savanthrapadian2014] demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino...”
- [Johantges2025] “In the dentate gyrus, HIPP cells represent the SST subtype analogous to O-LM cells, with somata in the hilus and axonal projections targeting the outer molecular layer where perforant path inputs arrive [Savanthrapadian2014, Raven2025b]. [Savanthrapadian2014] demonstrated that SOM-expressing interneurons in the dentate gyrus display facilitating excitatory synaptic inputs — a property shared with neocortical Martino...”
- [Hartwich2009] “The most striking functional distinction between hippocampal SST subtypes emerges during network oscillations. The landmark juxtacellular recording studies of Klausberger, Somogyi, and colleagues established that O-LM and bistratified cells fire at distinct phases of the theta rhythm and show opposing modulation during sharp-wave ripples (SWRs) [Hartwich2009]. This work, conducted primarily in anesthetized and head-...”
- [Lasztoczi2014] “Qualitative comparison of O-LM and bistratified cell activity across hippocampal network states and oscillation coupling profiles. (a) Relative firing rates during theta oscillations, sharp-wave ripples, and quiet wakefulness/sleep, synthesized from juxtacellular recording studies in rat CA1. (b) Coupling strength to theta, slow gamma, fast gamma, and SWR events [Hartwich2009, Lasztoczi2014]. Metric definitions vary...”
- [Cutsuridis2010] “The laminar specificity of hippocampal SST subtypes positions them as potential gatekeepers of information flow between hippocampal subregions. Computational models first proposed this idea: [Cutsuridis2010] modeled the CA1 microcircuit and found that O-LM cell activation favors retrieval by suppressing entorhinal cortex input to distal dendrites while allowing CA3-driven recall through proximal dendrites [Cutsuridi...”
- [AeryJones2021] “The laminar specificity of hippocampal SST subtypes positions them as potential gatekeepers of information flow between hippocampal subregions. Computational models first proposed this idea: [Cutsuridis2010] modeled the CA1 microcircuit and found that O-LM cell activation favors retrieval by suppressing entorhinal cortex input to distal dendrites while allowing CA3-driven recall through proximal dendrites [Cutsuridi...”
- [Lodge2023] “The gating function extends beyond the hippocampal formation proper. [Lodge2023] showed that discrete hippocampal output projections are differentially regulated by PV and SST interneurons, with SST interneuron activity selectively modulating specific projection pathways [Lodge2023]. [Zhang2024] demonstrated that frontal cortex SST interneurons gate hippocampal inputs in a learning-dependent manner, revealing cross-...”
- [Zhang2024] “The gating function extends beyond the hippocampal formation proper. [Lodge2023] showed that discrete hippocampal output projections are differentially regulated by PV and SST interneurons, with SST interneuron activity selectively modulating specific projection pathways [Lodge2023]. [Zhang2024] demonstrated that frontal cortex SST interneurons gate hippocampal inputs in a learning-dependent manner, revealing cross-...”
- [LovettBarron2014] “The most robust evidence for hippocampal SST function in behavior comes from memory paradigms. [LovettBarron2014] demonstrated that aversive stimuli activate CA1 dendrite-targeting (SOM+) interneurons via cholinergic input, leading to inhibition of pyramidal cell distal dendrites receiving aversive sensory excitation from the entorhinal cortex [LovettBarron2014]. Inactivating these dendrite-targeting interneurons du...”
- [Artinian2019] “Subsequent studies expanded the behavioral repertoire. [Artinian2019] showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it [Artinian2019]. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par...”
- [Honore2022] “Subsequent studies expanded the behavioral repertoire. [Artinian2019] showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it [Artinian2019]. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par...”
- [Honore2021] “Subsequent studies expanded the behavioral repertoire. [Artinian2019] showed that mTORC1 activity in hippocampal SST interneurons bidirectionally regulates contextual fear and spatial memory consolidation — upregulation of mTORC1 enhances memory while downregulation impairs it [Artinian2019]. This bidirectional modulation through a molecular signaling pathway provides mechanistic depth beyond the acute silencing par...”
- [Zicho2023] “The relationship between SST inhibition and memory recall, however, introduces apparent paradoxes. [Zicho2023] demonstrated that when fear was associated with inhibition of hippocampal SST interneurons, re-inhibition of the same interneurons could recall fear memory — suggesting that the pattern of SST activity during encoding becomes part of the memory trace itself, and reactivating that pattern is sufficient for r...”
- [Lacagnina2024] “The relationship between SST inhibition and memory recall, however, introduces apparent paradoxes. [Zicho2023] demonstrated that when fear was associated with inhibition of hippocampal SST interneurons, re-inhibition of the same interneurons could recall fear memory — suggesting that the pattern of SST activity during encoding becomes part of the memory trace itself, and reactivating that pattern is sufficient for r...”
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