Neuroinflammation and Immune Signaling Consensus

Consensus Summary

Microglia, astrocytes, complement, inflammasomes, cytokines, and innate/adaptive immune programs amplify or resolve disease processes.

This consensus cluster currently contains 547 active SciDEX hypotheses with average composite score 0.5974. Disease coverage: cross_neurodegeneration: 314, neuroinflammation: 63, AD: 40, unspecified: 38, synaptic biology: 14, biomarkers: 10, immunomics: 10, developmental neurobiology: 8.

Cross-Disease Signal

Shared disease buckets represented here: AD, PD, ALS, FTD, cross_neurodegeneration. Clusters with AD/PD/ALS/FTD co-coverage are priority targets for transfer hypotheses, debate scheduling, and Forge validation tasks.

Top Hypotheses

• Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration (h-var-08a4d5c07a): neurodegeneration, score 0.92377

• SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence (h-var-b7de826706): neurodegeneration, score 0.89273

• TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration (h-var-66156774e7): neurodegeneration, score 0.891957

Category Definition

Mechanism terms used for deterministic assignment: microgl, astrocy, inflamm, cytokine, complement, c1q, c3, trem2, apoe, nf-kb, nfkb, sting, cgas, inflammasome, nlrp3, immune, interferon, sasp, tnf, il-1, ifng.

Provenance

Generated by scripts/atlas_mechanism_consensus_map.py for Atlas task be26e8ca-f0cf-4a8d-b2ed-31a8e19e8c71 from the live PostgreSQL hypotheses table. Hypotheses are linked to the cluster node through knowledge_edges.relation='belongs_to_pathway_cluster'.