RNA Processing, Splicing, and RNP Granules Consensus

Consensus Summary

RNA-binding proteins, splicing factors, transport granules, stress granules, and repeat-associated RNA toxicity disturb neuronal RNA homeostasis.

This consensus cluster currently contains 59 active SciDEX hypotheses with average composite score 0.5968. Disease coverage: cross_neurodegeneration: 46, unspecified: 4, ALS: 3, multi: 2, AD: 1, FTD: 1, protein biochemistry: 1, synaptic biology: 1.

Cross-Disease Signal

Shared disease buckets represented here: AD, ALS, FTD, cross_neurodegeneration. Clusters with AD/PD/ALS/FTD co-coverage are priority targets for transfer hypotheses, debate scheduling, and Forge validation tasks.

Top Hypotheses

• RBM45 Liquid-Liquid Phase Separation Dominance Hijacks RNA Processing Condensates Toward Pathological Aggregation in ALS (h-alsmnd-9d62ae58bdc1): ALS, score 0.868053

• SFPQ Paralog Displacement Triggers Cryptic Polyadenylation and Global RNA Stability Loss in ALS Motor Neurons (h-alsmnd-c5d2e9c2edeb): ALS, score 0.864139

• C9ORF72 autophagy-lysosome collapse across ALS and FTD (h-cross-synth-c9orf72-autophagy-lysosome): multi, score 0.816

Category Definition

Mechanism terms used for deterministic assignment: rna, splicing, splice, rnp, stress granule, granule, tdp, fus, hnrnp, c9orf72, repeat, dipeptide, mrna, mirna, lncrna, nucleocytoplasmic, nuclear pore.

Provenance

Generated by scripts/atlas_mechanism_consensus_map.py for Atlas task be26e8ca-f0cf-4a8d-b2ed-31a8e19e8c71 from the live PostgreSQL hypotheses table. Hypotheses are linked to the cluster node through knowledge_edges.relation='belongs_to_pathway_cluster'.