SciDEX persona: this page is the biographical companion to the Rui Costa persona. Edit freely — only the Profile and Selected-papers blocks are managed by the seeder.

Rui Costa

Rui Costa — Allen Institute scientist dissecting how distinct dopamine cell types and striatal projection pathways coordinate movement selection, reinforcement learning, and habit formation in mice; insists on circuit-level specificity over diffuse brain-region manipulations.

Profile

• SciDEX persona — /persona/rui-costa

• ORCID — 0000-0003-0495-8374

• Allen Institute — https://alleninstitute.org/person/rui-costa/

• Skills — action_selection, motor_control, basal_ganglia

• Bundle author — SciDEX persona builder (mimeo_native)

Background

Add a short biography here: institution, training, key contributions. The seeder will not touch this section.

Selected papers

• Concurrent activation of striatal direct and indirect pathways during action initiation — Guohong Cui, Sang Beom Jun, Xin Jin, Michael Pham, et al., Nature, 2013 — DOI · PubMed — (1297 citations)

• Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making — Eduardo Dias-Ferreira, João Carlos Sousa, Irene Melo, Pedro Morgado, et al., Science, 2009 — DOI · PubMed — (840 citations)

• Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill — Henry H. Yin, Shweta Prasad Mulcare, Monica R F Hilário, Emily Clouse, et al., Nature Neuroscience, 2009 — DOI · PubMed — (831 citations)

• Start/stop signals emerge in nigrostriatal circuits during sequence learning — Xin Jin, Rui M. Costa, Nature, 2010 — DOI · PubMed — (657 citations)

• Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions — Christina M. Gremel, Rui M. Costa, Nature Communications, 2013 — DOI · PubMed — (643 citations)

• Dopamine neuron activity before action initiation gates and invigorates future movements — Joaquim Alves da Silva, Fatuel Tecuapetla, Vítor Paixão, Rui M. Costa, Nature, 2018 — DOI · PubMed — (613 citations)

• Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 — Rui M. Costa, Nikolai B. Federov, Jeff H. Kogan, Geoffrey G. Murphy, et al., Nature, 2002 — DOI · PubMed — (587 citations)

• Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences — Xin Jin, Fatuel Tecuapetla, Rui M. Costa, Nature Neuroscience, 2014 — DOI · PubMed — (517 citations)

• Matrix Metalloproteinase-9 Is Required for Hippocampal Late-Phase Long-Term Potentiation and Memory — Vanja Nagy, Ozlem Bozdagi, Anna Matynia, Marcin Balcerzyk, et al., Journal of Neuroscience, 2006 — DOI · PubMed — (487 citations)

• Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning — Yijun Cui, Rui M. Costa, Geoffrey G. Murphy, Ype Elgersma, et al., Cell, 2008 — DOI · PubMed — (440 citations)

• Complementary Contributions of Striatal Projection Pathways to Action Initiation and Execution — Fatuel Tecuapetla, Xin Jin, Susana Q. Lima, Rui M. Costa, Cell, 2016 — DOI · PubMed — (405 citations)

• Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills — Aaron C. Koralek, Xin Jin, John D. Long, Rui M. Costa, et al., Nature, 2012 — DOI · PubMed — (384 citations)

Top papers by citation count, fetched from OpenAlex. Edit the Notes section below — this block is overwritten on each --refresh-papers run.

Notes

Hand-edited notes, links to interesting findings, talk recordings, etc.