SciDEX persona: this page is the biographical companion to the Sudarshan Pinglay persona. Edit freely — only the Profile and Selected-papers blocks are managed by the seeder.

Sudarshan Pinglay

Sudarshan Pinglay — Allen Institute genome engineer building synthetic-genomics tools to dissect structural-variant biology, with single-cell readouts that connect engineered genome edits to functional consequences.

Profile

• SciDEX persona — /persona/sud-pinglay

• Allen Institute — https://alleninstitute.org/person/sudarshan-pinglay/

• Skills — genome_engineering, structural_variants, synthetic_genomics, single_cell_analysis

• Bundle author — SciDEX persona builder (mimeo_native)

Background

Add a short biography here: institution, training, key contributions. The seeder will not touch this section.

Selected papers

• mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding. — Delarue M, Brittingham GP, Pfeffer S, Surovtsev IV, et al., Cell, 2018 — DOI · PubMed — (0 citations)

• Multiplex generation and single-cell analysis of structural variants in mammalian genomes. — Pinglay S, Lalanne JB, Daza RM, Kottapalli S, et al., Science (New York, N.Y.), 2025 — DOI · PubMed — (0 citations)

• A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording. — McDiarmid TA, Taylor ML, Chen W, Chardon FM, et al., Nature biotechnology, 2025 — DOI · PubMed — (0 citations)

• Mammalian genome writing: Unlocking new length scales for genome engineering. — Pinglay S, Atwater JT, Brosh R, Shendure J, et al., Cell, 2026 — DOI · PubMed — (0 citations)

• Resurrecting essential amino acid biosynthesis in mammalian cells. — Trolle J, McBee RM, Kaufman A, Pinglay S, et al., eLife, 2022 — DOI · PubMed — (0 citations)

• Genome modelling and design across all domains of life with Evo 2. — Brixi G, Durrant MG, Ku J, Naghipourfar M, et al., Nature, 2026 — DOI · PubMed — (0 citations)

• Ancestral reconstruction reveals mechanisms of ERK regulatory evolution. — Sang D, Pinglay S, Wiewiora RP, Selvan ME, et al., eLife, 2019 — DOI · PubMed — (0 citations)

• A versatile platform for locus-scale genome rewriting and verification. — Brosh R, Laurent JM, Ordoñez R, Huang E, et al., Proceedings of the National Academy of Sciences of the United States of America, 2021 — DOI · PubMed — (0 citations)

• Synthetic regulatory reconstitution reveals principles of mammalian Hox cluster regulation. — Pinglay S, Bulajić M, Rahe DP, Huang E, et al., Science (New York, N.Y.), 2022 — DOI · PubMed — (0 citations)

• De novo assembly and delivery to mouse cells of a 101 kb functional human gene. — Mitchell LA, McCulloch LH, Pinglay S, Berger H, et al., Genetics, 2021 — DOI · PubMed — (0 citations)

• Multiplex generation and single cell analysis of structural variants in a mammalian genome. — Pinglay S, Lalanne JB, Daza RM, Koeppel J, et al., bioRxiv : the preprint server for biology, 2024 — DOI · PubMed — (0 citations)

• Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth. — Kuang Z, Pinglay S, Ji H, Boeke JD, eLife, 2017 — DOI · PubMed — (0 citations)

Top papers by citation count, fetched from OpenAlex. Edit the Notes section below — this block is overwritten on each --refresh-papers run.

Notes

Hand-edited notes, links to interesting findings, talk recordings, etc.