Overview
Gap43 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Gap43 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. 1GABAergic signaling in the central nervous systemOpen reference
--- 2Inhibitory neurotransmission and neurological disordersOpen reference title: GAP43 Protein 3Molecular mechanisms of neuronal inhibitionOpen reference description: GAP43 (neuromodulin) is a neuronal phosphoprotein that plays critical roles in axonal growth, nerve ... 4Neural circuit modulation by GABA receptorsOpen reference tags: protein, neurodegeneration, synaptic protein, motor protein, dynactin 5Neurotransmitter systems in brain functionOpen reference --- 6Synaptic transmission and neural circuitsOpen reference
Protein Name: Growth Associated Protein 43 (Neuromodulin)
Gene: GAP43
UniProt ID: P17642
PDB ID: 2N2T
Molecular Weight: 23.6 kDa
Subcellular Localization: Plasma membrane, Growth cones, Axon terminals
Protein Family: Neuromodulin family
Structure
GAP43 has a distinctive structure adapted for its function:
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Molecular Weight: 23.6 kDa
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Localization: Plasma membrane, Growth cones, Axon terminals
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Family: Neuromodulin family
Normal Function
GAP43 (neuromodulin) is a neuronal phosphoprotein that plays critical roles in axonal growth, nerve terminal development, and synaptic plasticity. It is highly expressed in developing neurons and re-induced during regeneration. GAP43 modulates calmodulin availability, regulates actin cytoskeleton dynamics, and affects neurotransmitter release. Its palmitoylation targets it to the plasma membrane of growth cones.
Role in Disease
Altered GAP43 expression is observed in Alzheimer’s disease, schizophrenia, and following nerve injury. It serves as a marker for axonal regeneration.
Therapeutic Targeting
GAP43 represents a potential therapeutic target:
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Enhancing axonal transport in neurodegeneration
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Modulating synaptic function
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Gene therapy approaches
Key Publications
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GAP43 in neurological disease - Reviews the role of GAP43 in neurodegeneration.
Cross-links
Overview
Gap43 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Gap43 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
See Also
External Links
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PubMed - Biomedical literature
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Alzheimer’s Disease Neuroimaging Initiative - Research data
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Allen Brain Atlas - Brain gene expression data
References
- GABAergic signaling in the central nervous system
- Inhibitory neurotransmission and neurological disorders
- Molecular mechanisms of neuronal inhibition
- Neural circuit modulation by GABA receptors
- Neurotransmitter systems in brain function
- Synaptic transmission and neural circuits
- Cellular mechanisms of neural signaling
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