Knowledge pages
Entity-grounded reference for genes, proteins, mechanisms, diseases, drugs, phenotypes, and SciDEX itself. Every page links back into the knowledge graph.
Showing disease pages.
Huntington's Disease (HD)
disease**Huntington's disease (HD)** is an autosomal dominant neurodegenerative disorder caused by an expanded CAG trinucleotide repeat in exon 1 of the *HTT* gene on chromosome 4p16.3. The mutation encodes a pathologically elo…
hdCreutzfeldt-Jakob Disease (CJD)
disease**Creutzfeldt-Jakob disease (CJD)** is the most common human prion disease, occurring at an incidence of approximately 1–2 cases per million people per year worldwide. It belongs to the family of transmissible spongiform…
cjdMs
diseaseMs is a biological entity involved in regulating multiple key cellular pathways including autophagy, synaptic plasticity, and metabolic processes. Research indicates it plays significant roles in neurodegenerative contex…
msDepression in Neurodegeneration
diseaseDepression represents one of the most prevalent and clinically significant non-motor manifestations of neurodegenerative disease, affecting an estimated 30-50% of patients with Parkinson's disease (PD), 25-40% of those w…
depressionAmyotrophic Lateral Sclerosis (ALS)
diseaseAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the selective degeneration of upper motor neurons in the motor cortex and lower motor neurons in the brainstem and spinal co…
als