Knowledge pages
Entity-grounded reference for genes, proteins, mechanisms, diseases, drugs, phenotypes, and SciDEX itself. Every page links back into the knowledge graph.
Showing hypothesis pages.
APOE contributes to Alzheimer's disease by regulating both beta-amyloid deposition
hypothesisThe **APOE (Apolipoprotein E)** hypothesis proposes that APOE contributes to Alzheimer's disease (AD) through multiple parallel pathways, primarily by regulating [beta-amyloid](/proteins/amyloid-beta) deposition and modu…
hypotheses-apoe-contributes-alzheimer's-disease-regulatAlzheimer's disease pathology originates in the hippocampus and subsequently spreads
hypothesisThis hypothesis proposes that **[Alzheimer's disease](/diseases/alzheimers-disease) pathology originates in the [hippocampus](/brain-regions/hippocampus) and subsequently spreads to temporal, parietal, and prefrontal ass…
hypotheses-alzheimer's-disease-pathology-originates-hiIn Alzheimer's disease, biomarker events occur in a specific temporal sequence: amyloid-β abnormalit
hypothesisThis hypothesis proposes that **In Alzheimer's disease, biomarker events occur in a specific temporal sequence**: amyloid-β abnormalities (CSF and PET) first, followed by [tau](/proteins/tau) abnormalities (CSF), then st…
hypotheses-alzheimer's-disease,-biomarker-events-occurDisease Model: Declining functional connectivity of the Default Mode Network in Alzheimer's Disease
hypothesisThe **Default Mode Network (DMN)** is a constellation of brain regions that demonstrate synchronized activity during resting-state conditions and deactivate during externally directed cognitive tasks[@buckner2009]. This…
hypotheses-hyp_963428Mechanistic Proposal: Pathologic synergy: The pathologic aggregation of...
hypothesisPathologic synergy refers to the phenomenon wherein the pathologic aggregation of one protein can work synergistically to initiate or otherwise promote the aggregation of different protein species in the aged human brain…
hypotheses-hyp_885074Therapeutic Hypothesis: TDP-43 and a-synuclein pathologies in the amygdala...
hypothesisThe co-occurrence of TDP-43 and [alpha-synuclein](/proteins/alpha-synuclein) pathologies in the amygdala represents a significant pathological intersection in neurodegenerative diseases. This hypothesis posits that these…
hypotheses-hyp_575716Neuritic Amyloid Plaques — Histomorphologic Evidence of Pathologic Synergy in AD
hypothesisNeuritic amyloid plaques provide histomorphologic evidence of pathologic synergy, wherein extracellular [amyloid-beta](/proteins/amyloid-beta) (Aβ) deposits trigger intracellular [tau](/proteins/tau) misfolding in nearby…
hypotheses-hyp_37312Prion-Like Propagation of Proteinopathies — Template-Directed Misfolding in Neurodegeneration
hypothesisProteinopathic processes spread through the brain in a 'prion-like' manner, where misfolded protein aggregates can template the conformational conversion of normal proteins, leading to progressive neuropathology that fol…
hypotheses-hyp_332160Alzheimer's Disease Neuropathology is Defined by the Accumulation of Pathological Amyloid-Beta in the Form of Senile Plaques and Dystrophic Neurites, and Phosphorylated Tau Neurofibrillary Tangles
hypothesisThis hypothesis establishes that **Alzheimer's disease neuropathology is defined by the accumulation of pathological amyloid-beta (Aβ) in the form of senile plaques and dystrophic neurites, and phosphorylated tau neurofi…
hypotheses-hyp_15575Mechanistic Proposal: Amyloid Plaque and Neurofibrillary Tangle Deposition is Essential for Accurate Modeling of AD in Mouse Models
hypothesisAmyloid plaque and neurofibrillary tangle deposition is an essential component for accurate modeling of Alzheimer's disease in mouse models [@neuropathological2018]. This hypothesis addresses the critical need for precli…
hypotheses-hyp_871297Mechanistic Proposal: Chemical changes (namely hyperphosphorylation) occ...
hypothesisTau hyperphosphorylation represents one of the most well-established pathological mechanisms in Alzheimer's disease (AD) and other tauopathies. This page details the molecular cascade from normal tau function to patholog…
hypotheses-hyp_87091Tau Pathology Severity Assessment Model — Braak Staging and Disease Progression
hypothesisThe ability to identify and evaluate the severity of [tau](/proteins/tau) pathology in the brain represents a critical component of [Alzheimer's disease](/diseases/alzheimers-disease) diagnosis and disease progression st…
hypotheses-hyp_436169K-Cardinality Tree (KCT) Network Optimization for DMN Connectivity Analysis in Cognitive Decline
hypothesisThis hypothesis proposes that the k-cardinality tree (KCT) network optimization approach provides superior sensitivity compared to traditional regional homogeneity (ReHo) methods for detecting significant functional conn…
hypotheses-hyp_409736Alterations in Intra-Regional Functional Connectivity Within Default Mode Network Regions
hypothesisThis hypothesis proposes that **alterations in intra-regional functional connectivity within Default Mode Network (DMN) regions are associated with cognitive decline in aging individuals**, representing a key mechanism d…
hypotheses-hyp_24486The Cortical/Transitional Zone of the Amygdala is Affected Early in Neurodegenerative Diseases
hypothesisThis hypothesis proposes that **the cortical/transitional zone of the amygdala is affected relatively early in the course of multiple neurodegenerative diseases** [1]. This region, also known as the olfactory amygdala or…
hypotheses-hyp_146258