Conclusion and Outlook

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Source: https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/content/15_conclusion.md

Citation anchors captured: 48

Citation contexts

^{1Citationpaper:paper-76ca66ad8e8eThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{7Citationpaper:paper-d0cb090accd6The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{8Citationpaper:paper-34d86b4a1c4eThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{9Citationpaper:paper-b0d4d16b6b56The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{10Citationpaper:paper-31593cb69c1cThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference} The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...
^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}0 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}1, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}2 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}3, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}4 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}5, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}6 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}7, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}8 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{2Citationpaper:paper-4ed3380941f5The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}9, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}0 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}1, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}2 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}3, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}4 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}5, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}6 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}7, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}8 Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs ^{3Citationpaper:paper-02fe2b77fe38The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}9, but causal perturbation still depends on a small set of mouse lines (IP₃R2-KO, dnSNARE, Aldh1l1-Cre/...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}0 Compartment-specific, conditional calcium manipulations. The IP₃R2-knockout controversy cannot be settled by further use of the IP₃R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}1 Compartment-specific, conditional calcium manipulations. The IP₃R2-knockout controversy cannot be settled by further use of the IP₃R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}2 Compartment-specific, conditional calcium manipulations. The IP₃R2-knockout controversy cannot be settled by further use of the IP₃R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}3 Compartment-specific, conditional calcium manipulations. The IP₃R2-knockout controversy cannot be settled by further use of the IP₃R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}4 Compartment-specific, conditional calcium manipulations. The IP₃R2-knockout controversy cannot be settled by further use of the IP₃R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}5 Compartment-specific, conditional calcium manipulations. The IP₃R2-knockout controversy cannot be settled by further use of the IP₃R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}6 Compartment-specific, conditional calcium manipulations. The IP₃R2-knockout controversy cannot be settled by further use of the IP₃R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}7 Adjudication of adult-cortex vesicular gliotransmission. The specific claim that survives critical re-examination is that in acute slice and development, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex in vivo. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}8 Adjudication of adult-cortex vesicular gliotransmission. The specific claim that survives critical re-examination is that in acute slice and development, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex in vivo. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...
^{4Citationpaper:paper-c0990b7b4903The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}9 Adjudication of adult-cortex vesicular gliotransmission. The specific claim that survives critical re-examination is that in acute slice and development, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex in vivo. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}0 Adjudication of adult-cortex vesicular gliotransmission. The specific claim that survives critical re-examination is that in acute slice and development, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex in vivo. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}1 Adjudication of adult-cortex vesicular gliotransmission. The specific claim that survives critical re-examination is that in acute slice and development, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex in vivo. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}2 Direct quantitative tests of the acute ANLS locus. Section {ref}sec:metabolic-coupling left open whether the acute glucose-uptake locus is astrocytic or neuronal. Simultaneous, cell-type-resolved glucose and lactate sensors — genetically encoded variants expressed from astrocyte and neuron-specific promoters in the same animal and the same stimulus — are the minimum experiment required to adjudicate it. Sensor t...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}3 Direct quantitative tests of the acute ANLS locus. Section {ref}sec:metabolic-coupling left open whether the acute glucose-uptake locus is astrocytic or neuronal. Simultaneous, cell-type-resolved glucose and lactate sensors — genetically encoded variants expressed from astrocyte and neuron-specific promoters in the same animal and the same stimulus — are the minimum experiment required to adjudicate it. Sensor t...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}4 Systematic regional and species benchmarking. Section {ref}sec:regional-diversity documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca²⁺ statistics even under identical indicators, and Section {ref}sec:species-disease showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}5 Systematic regional and species benchmarking. Section {ref}sec:regional-diversity documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca²⁺ statistics even under identical indicators, and Section {ref}sec:species-disease showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}6 Systematic regional and species benchmarking. Section {ref}sec:regional-diversity documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca²⁺ statistics even under identical indicators, and Section {ref}sec:species-disease showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}7 Systematic regional and species benchmarking. Section {ref}sec:regional-diversity documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca²⁺ statistics even under identical indicators, and Section {ref}sec:species-disease showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}8 Systematic regional and species benchmarking. Section {ref}sec:regional-diversity documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca²⁺ statistics even under identical indicators, and Section {ref}sec:species-disease showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...
^{5Citationpaper:paper-744cd4da2e4aThe review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}9 Systematic regional and species benchmarking. Section {ref}sec:regional-diversity documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca²⁺ statistics even under identical indicators, and Section {ref}sec:species-disease showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...
^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}0 Systematic regional and species benchmarking. Section {ref}sec:regional-diversity documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca²⁺ statistics even under identical indicators, and Section {ref}sec:species-disease showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...
^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}1 Section {ref}sec:computational-models made its own pointed critique: the formal-model tier is uneven in reproducibility, with code availability, parameter-sweep transparency, and regional parameterisation all inconsistent across published studies ^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}2. The forward-looking priorities are therefore as much sociotechnical as scient...
^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}3 Section {ref}sec:computational-models made its own pointed critique: the formal-model tier is uneven in reproducibility, with code availability, parameter-sweep transparency, and regional parameterisation all inconsistent across published studies ^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}4. The forward-looking priorities are therefore as much sociotechnical as scient...
^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}5 Section {ref}sec:computational-models made its own pointed critique: the formal-model tier is uneven in reproducibility, with code availability, parameter-sweep transparency, and regional parameterisation all inconsistent across published studies ^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}6. The forward-looking priorities are therefore as much sociotechnical as scient...
^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}7 Regionally and species-parameterised tripartite-synapse models. The tripartite-synapse tier of Section {ref}sec:computational-models is currently parameterised from rodent hippocampal slice ^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}8. Variants parameterised explicitly against cortical, striatal, cerebellar, and human-iPSC-derived data would make region-...
^{6Citationpaper:paper-374a998f7856The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}9 Regionally and species-parameterised tripartite-synapse models. The tripartite-synapse tier of Section {ref}sec:computational-models is currently parameterised from rodent hippocampal slice ^{7Citationpaper:paper-d0cb090accd6The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}0. Variants parameterised explicitly against cortical, striatal, cerebellar, and human-iPSC-derived data would make region-...
^{7Citationpaper:paper-d0cb090accd6The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}1 Regionally and species-parameterised tripartite-synapse models. The tripartite-synapse tier of Section {ref}sec:computational-models is currently parameterised from rodent hippocampal slice ^{7Citationpaper:paper-d0cb090accd6The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}2. Variants parameterised explicitly against cortical, striatal, cerebellar, and human-iPSC-derived data would make region-...
^{7Citationpaper:paper-d0cb090accd6The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}3 Regionally and species-parameterised tripartite-synapse models. The tripartite-synapse tier of Section {ref}sec:computational-models is currently parameterised from rodent hippocampal slice ^{7Citationpaper:paper-d0cb090accd6The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical in vivo astrocyte data at subcellular resolution are nearly absent; the human findings that are avail...content/15_conclusion.md:line 8Open reference}4. Variants parameterised explicitly against cortical, striatal, cerebellar, and human-iPSC-derived data would make region-...

References

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[falcone_2019_jcomparative] paper:paper-4ed3380941f5 “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[vasile_2017_brainstruct] paper:paper-02fe2b77fe38 “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[han_2013_cellstem] paper:paper-c0990b7b4903 “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[goldman_2015_glia] paper:paper-744cd4da2e4a “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[krencik_2011_natbiotechnol] paper:paper-374a998f7856 “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[manninen_2018_frontcomput] paper:paper-d0cb090accd6 “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[manninen_2018_frontneuroinform] paper:paper-34d86b4a1c4e “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[bezerra_2024_ploscomput] paper:paper-b0d4d16b6b56 “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[jiang_2025_ploscomput] paper:paper-31593cb69c1c “The review is uneven in two ways that deserve to be made explicit before any forward-looking list is offered. First, the literature it summarises is dominated by rodent hippocampal slice physiology and head-fixed two-photon imaging in mouse somatosensory, visual, and cerebellar cortex. Primate and human cortical *in vivo* astrocyte data at subcellular resolution are nearly absent; the human findings that *are* avail...”
[akerboom_2012_jneurosci] paper:0281bdfb-227b-460b-8d6d-8970336b6b93 “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[akerboom_2013_frontmol] paper:paper-adb90fa042bb “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[shigetomi_2013_neuroscience] paper:paper-bd699ea0aec5 “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[srinivasan_2015_natneurosci] paper:paper-883c8368100c “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[agarwal_2017_neuron] paper:paper-54c454be2778 “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[petravicz_2008_jneurosci] paper:paper-778045e57b0f “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[agulhon_2010_science] paper:paper-b422988f09f8 “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[fiacco_2007_neuron] paper:paper-9f16bd0faa11 “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[savtchouk_2018_jneurosci] paper:paper-930310f9ad4c “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[fujita_2014_jneurosci] paper:paper-5fe7a4267091 “Second, the tool landscape for astrocyte manipulation remains asymmetric. Calcium-imaging resolution has advanced dramatically with GCaMP6/7 variants and membrane-tethered GECIs [akerboom_2012_jneurosci, akerboom_2013_frontmol, shigetomi_2013_neuroscience, srinivasan_2015_natneurosci, agarwal_2017_neuron], but causal perturbation still depends on a small set of mouse lines (IP3R2-KO, dnSNARE, Aldh1l1-Cre/...”
[adamsky_2018_cell] paper:paper-79c338afafe0 “*Compartment-specific, conditional calcium manipulations.* The IP3R2-knockout controversy cannot be settled by further use of the IP3R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...”
[mederos_2019_glia] paper:paper-e160006c27bd “*Compartment-specific, conditional calcium manipulations.* The IP3R2-knockout controversy cannot be settled by further use of the IP3R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...”
[depitta_2009_jbiol] paper:paper-0f5b9fa4492c “*Compartment-specific, conditional calcium manipulations.* The IP3R2-knockout controversy cannot be settled by further use of the IP3R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...”
[depitta_2011_ploscomput] paper:paper-034e481c0805 “*Compartment-specific, conditional calcium manipulations.* The IP3R2-knockout controversy cannot be settled by further use of the IP3R2 knockout alone. What is needed are manipulations that dissociate the somatic, branch, perisynaptic, and endfoot compartments — for example, spatially targeted chemogenetic or optogenetic actuators expressed from promoters that restrict expression to identified...”
[marvin_2013_natmethods] paper:paper-e41ad5ac59b2 “*Adjudication of adult-cortex vesicular gliotransmission.* The specific claim that survives critical re-examination is that *in acute slice and development*, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex *in vivo*. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...”
[araque_2014_neuron] paper:paper-4c0b69613ffb “*Adjudication of adult-cortex vesicular gliotransmission.* The specific claim that survives critical re-examination is that *in acute slice and development*, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex *in vivo*. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...”
[durkee_2021_trendsneurosciences] paper:paper-05bd7b9585c9 “*Adjudication of adult-cortex vesicular gliotransmission.* The specific claim that survives critical re-examination is that *in acute slice and development*, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex *in vivo*. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...”
[goenaga_2023_frontsynaptic] paper:paper-2ea9ef87bc30 “*Adjudication of adult-cortex vesicular gliotransmission.* The specific claim that survives critical re-examination is that *in acute slice and development*, regulated astrocytic release measurably affects receptor-site physiology. The claim the field should now try to decide is whether that continues to be true in adult cortex *in vivo*. Combining iGluSnFR/iSeroSnFR-class reporters with single-astrocyte, compartmen...”
[lundgaard_2015_natcommun] paper:paper-c0ab0710be9a “*Direct quantitative tests of the acute ANLS locus.* Section {ref}`sec:metabolic-coupling` left open whether the acute glucose-uptake locus is astrocytic or neuronal. Simultaneous, cell-type-resolved glucose and lactate sensors — genetically encoded variants expressed from astrocyte and neuron-specific promoters in the same animal and the same stimulus — are the minimum experiment required to adjudicate it. Sensor t...”
[chuquet_2010_jneurosci] paper:paper-d02beb4568d2 “*Direct quantitative tests of the acute ANLS locus.* Section {ref}`sec:metabolic-coupling` left open whether the acute glucose-uptake locus is astrocytic or neuronal. Simultaneous, cell-type-resolved glucose and lactate sensors — genetically encoded variants expressed from astrocyte and neuron-specific promoters in the same animal and the same stimulus — are the minimum experiment required to adjudicate it. Sensor t...”
[chai_2017_neuron] paper:paper-c860b586a738 “*Systematic regional and species benchmarking.* Section {ref}`sec:regional-diversity` documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca2+ statistics even under identical indicators, and Section {ref}`sec:species-disease` showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...”
[yu_2018_neuron] paper:paper-9797394cf360 “*Systematic regional and species benchmarking.* Section {ref}`sec:regional-diversity` documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca2+ statistics even under identical indicators, and Section {ref}`sec:species-disease` showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...”
[khakh_2019_annurevneurosci] paper:paper-9e1d2df5c358 “*Systematic regional and species benchmarking.* Section {ref}`sec:regional-diversity` documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca2+ statistics even under identical indicators, and Section {ref}`sec:species-disease` showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...”
[batiuk_2020_natcommun] paper:paper-adc7c61857f7 “*Systematic regional and species benchmarking.* Section {ref}`sec:regional-diversity` documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca2+ statistics even under identical indicators, and Section {ref}`sec:species-disease` showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...”
[bayraktar_2020_natneurosci] paper:paper-6a1ea355aaf8 “*Systematic regional and species benchmarking.* Section {ref}`sec:regional-diversity` documented that cortex, hippocampus, striatum, and cerebellum produce quantitatively different Ca2+ statistics even under identical indicators, and Section {ref}`sec:species-disease` showed that rodent and human cortical astrocytes differ along at least morphometric, electrophysiological, and transcriptomic axes [chai_20...”
[manninen_2023_neuroinform] paper:paper-c060c4dc6b11 “Section {ref}`sec:computational-models` made its own pointed critique: the formal-model tier is uneven in reproducibility, with code availability, parameter-sweep transparency, and regional parameterisation all inconsistent across published studies [manninen_2018_frontneuroinform, manninen_2023_neuroinform, gonzalez_2020_frontneuroinform]. The forward-looking priorities are therefore as much sociotechnical as scient...”
[gonzalez_2020_frontneuroinform] paper:paper-0a76d5e73800 “Section {ref}`sec:computational-models` made its own pointed critique: the formal-model tier is uneven in reproducibility, with code availability, parameter-sweep transparency, and regional parameterisation all inconsistent across published studies [manninen_2018_frontneuroinform, manninen_2023_neuroinform, gonzalez_2020_frontneuroinform]. The forward-looking priorities are therefore as much sociotechnical as scient...”
[nadkarni_2008_ploscomput] paper:paper-56381b620993 “*Regionally and species-parameterised tripartite-synapse models.* The tripartite-synapse tier of Section {ref}`sec:computational-models` is currently parameterised from rodent hippocampal slice [nadkarni_2008_ploscomput, depitta_2009_jbiol, depitta_2011_ploscomput, depitta_2016_neuralplasticity]. Variants parameterised explicitly against cortical, striatal, cerebellar, and human-iPSC-derived data would make region-...”
[depitta_2016_neuralplasticity] paper:paper-60ff336af3f0 “*Regionally and species-parameterised tripartite-synapse models.* The tripartite-synapse tier of Section {ref}`sec:computational-models` is currently parameterised from rodent hippocampal slice [nadkarni_2008_ploscomput, depitta_2009_jbiol, depitta_2011_ploscomput, depitta_2016_neuralplasticity]. Variants parameterised explicitly against cortical, striatal, cerebellar, and human-iPSC-derived data would make region-...”

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