Synthesis and Evidence Assessment: What We Know, What We Think We Know, and Wha…

Synthesis and Evidence Assessment: What We Know, What We Think We Know, and What We Don’t

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• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference} The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}, and validated against computational...

• ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference} The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}, and validated against computational...

• ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference} The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}, and validated against computational...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference} The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1, and validated against computational...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2 The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4, and validated against computational...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5 The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7, and validated against computational...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8 The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0, and validated against computational...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1 The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3, and validated against computational...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4 The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6, and validated against computational...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7 The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8, extended across behavioral paradigms, confirmed with genetically encoded sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9, and validated against computational...

• ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0 Cholinergic cortical desynchronization represents another Tier 1 finding. Optogenetic stimulation of basal forebrain cholinergic neurons reliably produces cortical desynchronization, confirmed across multiple preparations ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1. However, the functional interpretation of this desynchronization remains debated: whether acetylcholine specifically enhances attention or acts as a more general...

• ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2 Cholinergic cortical desynchronization represents another Tier 1 finding. Optogenetic stimulation of basal forebrain cholinergic neurons reliably produces cortical desynchronization, confirmed across multiple preparations ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3. However, the functional interpretation of this desynchronization remains debated: whether acetylcholine specifically enhances attention or acts as a more general...

• ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4 Cholinergic cortical desynchronization represents another Tier 1 finding. Optogenetic stimulation of basal forebrain cholinergic neurons reliably produces cortical desynchronization, confirmed across multiple preparations ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5. However, the functional interpretation of this desynchronization remains debated: whether acetylcholine specifically enhances attention or acts as a more general...

• ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6 Noradrenergic enhancement of emotional memory consolidation, mediated through beta-adrenergic receptors in the basolateral amygdala, has been replicated across species and paradigms ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7. The locus coeruleus–amygdala pathway’s role in emotional memory has strong convergent support from pharmacological, lesion, and imaging studies. Cross-species validation extends from rodent fear...

• ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8 Noradrenergic enhancement of emotional memory consolidation, mediated through beta-adrenergic receptors in the basolateral amygdala, has been replicated across species and paradigms ^{2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9. The locus coeruleus–amygdala pathway’s role in emotional memory has strong convergent support from pharmacological, lesion, and imaging studies. Cross-species validation extends from rodent fear...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0 Noradrenergic enhancement of emotional memory consolidation, mediated through beta-adrenergic receptors in the basolateral amygdala, has been replicated across species and paradigms ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1. The locus coeruleus–amygdala pathway’s role in emotional memory has strong convergent support from pharmacological, lesion, and imaging studies. Cross-species validation extends from rodent fear...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2 Noradrenergic enhancement of emotional memory consolidation, mediated through beta-adrenergic receptors in the basolateral amygdala, has been replicated across species and paradigms ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3. The locus coeruleus–amygdala pathway’s role in emotional memory has strong convergent support from pharmacological, lesion, and imaging studies. Cross-species validation extends from rodent fear...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4 Noradrenergic enhancement of emotional memory consolidation, mediated through beta-adrenergic receptors in the basolateral amygdala, has been replicated across species and paradigms ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5. The locus coeruleus–amygdala pathway’s role in emotional memory has strong convergent support from pharmacological, lesion, and imaging studies. Cross-species validation extends from rodent fear...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6 The validation of genetically encoded neurotransmitter sensors deserves recognition as a methodological Tier 1 achievement. Sensors including dLight for dopamine ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7, GRAB sensors for multiple neuromodulators ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8, and NE sensors ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9 have been independently validated across laboratories, providing the field with tools whose measurement properties are themselves well-characteri...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0 The validation of genetically encoded neurotransmitter sensors deserves recognition as a methodological Tier 1 achievement. Sensors including dLight for dopamine ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1, GRAB sensors for multiple neuromodulators ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2, and NE sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3 have been independently validated across laboratories, providing the field with tools whose measurement properties are themselves well-characteri...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4 The validation of genetically encoded neurotransmitter sensors deserves recognition as a methodological Tier 1 achievement. Sensors including dLight for dopamine ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5, GRAB sensors for multiple neuromodulators ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6, and NE sensors ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7 have been independently validated across laboratories, providing the field with tools whose measurement properties are themselves well-characteri...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8 The validation of genetically encoded neurotransmitter sensors deserves recognition as a methodological Tier 1 achievement. Sensors including dLight for dopamine ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9, GRAB sensors for multiple neuromodulators ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0, and NE sensors ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1 have been independently validated across laboratories, providing the field with tools whose measurement properties are themselves well-characteri...

• ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2 The validation of genetically encoded neurotransmitter sensors deserves recognition as a methodological Tier 1 achievement. Sensors including dLight for dopamine ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3, GRAB sensors for multiple neuromodulators ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4, and NE sensors ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5 have been independently validated across laboratories, providing the field with tools whose measurement properties are themselves well-characteri...

• ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6 The validation of genetically encoded neurotransmitter sensors deserves recognition as a methodological Tier 1 achievement. Sensors including dLight for dopamine ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7, GRAB sensors for multiple neuromodulators ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8, and NE sensors ^{3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9 have been independently validated across laboratories, providing the field with tools whose measurement properties are themselves well-characteri...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1. Fast-scan cyclic voltammetry...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3. Fast-scan cyclic voltammetry...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5. Fast-scan cyclic voltammetry...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7. Fast-scan cyclic voltammetry...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9. Fast-scan cyclic voltammetry...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1. Fast-scan cyclic voltammetry...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3. Fast-scan cyclic voltammetry...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4 The methodological revolution in neurotransmitter sensing deserves particular emphasis as a Tier 1 achievement because it addresses a foundational measurement problem. Classical microdialysis provided neurochemical measurements with temporal resolution on the order of minutes — far too slow to capture the sub-second dynamics relevant to neural computation ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5. Fast-scan cyclic voltammetry...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6 Serotonergic modulation of impulse control and behavioral patience has been demonstrated in multiple paradigms, but primarily from a limited number of laboratories. The serotonin hypothesis of depression — arguably the most clinically consequential claim in the field — has been increasingly challenged. ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7 found that the main areas of serotonin research “provide no consistent evidence of” an association...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8 Serotonergic modulation of impulse control and behavioral patience has been demonstrated in multiple paradigms, but primarily from a limited number of laboratories. The serotonin hypothesis of depression — arguably the most clinically consequential claim in the field — has been increasingly challenged. ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 5Citationpaper:paper-8eda8b8cc145The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9 found that the main areas of serotonin research “provide no consistent evidence of” an association...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}0 Serotonergic modulation of impulse control and behavioral patience has been demonstrated in multiple paradigms, but primarily from a limited number of laboratories. The serotonin hypothesis of depression — arguably the most clinically consequential claim in the field — has been increasingly challenged. ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}1 found that the main areas of serotonin research “provide no consistent evidence of” an association...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}2 The dopamine inverted-U model for prefrontal cortical function — the idea that both too little and too much dopamine impair working memory — has clinical relevance for understanding cognitive dysfunction across psychiatric conditions ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}3. Yet the primary experimental demonstrations of this relationship are limited to a small number of studies, and the precise shape of the dose-response curve varies acros...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}4 The dopamine inverted-U model for prefrontal cortical function — the idea that both too little and too much dopamine impair working memory — has clinical relevance for understanding cognitive dysfunction across psychiatric conditions ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}5. Yet the primary experimental demonstrations of this relationship are limited to a small number of studies, and the precise shape of the dose-response curve varies acros...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}6 The norepinephrine system illustrates how competing models can persist when the experimental evidence is insufficient to distinguish them. ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}7 reviewed evidence that the P3 event-related potential reflects phasic LC-NE activity, linking noradrenergic function to attentional orienting and decision-making. This framework has been influential, but it competes with models emphasizing continuous gain modula...

• ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}8 The norepinephrine system illustrates how competing models can persist when the experimental evidence is insufficient to distinguish them. ^{4Citationpaper:paper-03fb2398da8aThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}9 reviewed evidence that the P3 event-related potential reflects phasic LC-NE activity, linking noradrenergic function to attentional orienting and decision-making. This framework has been influential, but it competes with models emphasizing continuous gain modula...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}00 The norepinephrine system illustrates how competing models can persist when the experimental evidence is insufficient to distinguish them. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}01 reviewed evidence that the P3 event-related potential reflects phasic LC-NE activity, linking noradrenergic function to attentional orienting and decision-making. This framework has been influential, but it competes with models emphasizing continuous gain modula...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}02 Cross-system interactions represent an emerging area where evidence is particularly thin relative to theoretical importance. The claim that neuromodulatory systems interact — that dopamine release modulates serotonin signaling, or that acetylcholine gates noradrenergic effects — is widely assumed but rarely tested directly. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}03 established calcium-dependent vesicular exocytosis as a mechanism for co-transmissi...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}04 Cross-system interactions represent an emerging area where evidence is particularly thin relative to theoretical importance. The claim that neuromodulatory systems interact — that dopamine release modulates serotonin signaling, or that acetylcholine gates noradrenergic effects — is widely assumed but rarely tested directly. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}05 established calcium-dependent vesicular exocytosis as a mechanism for co-transmissi...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}06 Cross-system interactions represent an emerging area where evidence is particularly thin relative to theoretical importance. The claim that neuromodulatory systems interact — that dopamine release modulates serotonin signaling, or that acetylcholine gates noradrenergic effects — is widely assumed but rarely tested directly. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}07 established calcium-dependent vesicular exocytosis as a mechanism for co-transmissi...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}08 Cross-system interactions represent an emerging area where evidence is particularly thin relative to theoretical importance. The claim that neuromodulatory systems interact — that dopamine release modulates serotonin signaling, or that acetylcholine gates noradrenergic effects — is widely assumed but rarely tested directly. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}09 established calcium-dependent vesicular exocytosis as a mechanism for co-transmissi...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}10 Cross-system interactions represent an emerging area where evidence is particularly thin relative to theoretical importance. The claim that neuromodulatory systems interact — that dopamine release modulates serotonin signaling, or that acetylcholine gates noradrenergic effects — is widely assumed but rarely tested directly. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}11 established calcium-dependent vesicular exocytosis as a mechanism for co-transmissi...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}12 Cross-system interactions represent an emerging area where evidence is particularly thin relative to theoretical importance. The claim that neuromodulatory systems interact — that dopamine release modulates serotonin signaling, or that acetylcholine gates noradrenergic effects — is widely assumed but rarely tested directly. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}13 established calcium-dependent vesicular exocytosis as a mechanism for co-transmissi...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}14 Cross-system interactions represent an emerging area where evidence is particularly thin relative to theoretical importance. The claim that neuromodulatory systems interact — that dopamine release modulates serotonin signaling, or that acetylcholine gates noradrenergic effects — is widely assumed but rarely tested directly. ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}15 established calcium-dependent vesicular exocytosis as a mechanism for co-transmissi...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}16 The cholinergic encoding/retrieval switching hypothesis — the claim that acetylcholine levels in hippocampus switch the network between encoding and retrieval modes — is commonly cited as a fundamental principle of memory systems neuroscience. Yet when we trace this claim through the citation chain, the primary experimental evidence is surprisingly thin, resting on a small number of studies from limited experimental...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}17 The cholinergic encoding/retrieval switching hypothesis — the claim that acetylcholine levels in hippocampus switch the network between encoding and retrieval modes — is commonly cited as a fundamental principle of memory systems neuroscience. Yet when we trace this claim through the citation chain, the primary experimental evidence is surprisingly thin, resting on a small number of studies from limited experimental...

• ^{1Citationpaper:paper-9125c3f23989The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 2Citationpaper:paper-aaa4ba331a59The dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference, 3Citationpaper:paper-b21635974c1fThe dopamine reward prediction error (RPE) signal stands as the most robustly established finding in neuromodulation neuroscience. Originally described in primate electrophysiology, the RPE framework has been extended to rodent preparations [Daw2002, Kakade2002, Suri2002], extended across behavioral paradigms, confirmed with genetically encoded sensors [Havens2025, Labouesse2024], and validated against computational...content/12_synthesis_evidence.md:line 14Open reference}18 The cholinergic encoding/retrieval switching hypothesis — the claim that acetylcholine levels in hippocampus switch the network between encoding and retrieval modes — is commonly cited as a fundamental principle of memory systems neuroscience. Yet when we trace this claim through the citation chain, the primary experimental evidence is surprisingly thin, resting on a small number of studies from limited experimental...

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