Intrinsic Electrophysiology: The Fast-Spiking Phenotype and Its Variants
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1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference The molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in{ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference, represents the functional... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference. These properties distinguish PV interneurons from all other cortical neuron classes... -
3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference. These properties distinguish PV interneurons from all other cortical neuron classes... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference. These properties distinguish PV interneurons from all other cortical neuron classes... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference. These properties distinguish PV interneurons from all other cortical neuron classes... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference0 The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference1. These properties distinguish PV interneurons from all other cortical neuron classes... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference2 The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference3. These properties distinguish PV interneurons from all other cortical neuron classes... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference4 The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference5. These properties distinguish PV interneurons from all other cortical neuron classes... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference6 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference7, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference8 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference9, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference0 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference1, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...
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2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference2 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference3, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...
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2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference4 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference5, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...
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2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference6 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference7, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...
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2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference8 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference9, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...
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2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference0 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference1, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference2 The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference3, making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference4 Quantitative thresholds for the FS phenotype vary across studies and recording conditions, partly reflecting genuine biological differences. PV interneuron firing properties vary systematically across cortical areas, with differences in maximum firing rate, input resistance, and spike width reflecting area-specific computational demands 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference5. Computational modeling of PV interneurons has demonstra... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference6 Quantitative thresholds for the FS phenotype vary across studies and recording conditions, partly reflecting genuine biological differences. PV interneuron firing properties vary systematically across cortical areas, with differences in maximum firing rate, input resistance, and spike width reflecting area-specific computational demands 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference7. Computational modeling of PV interneurons has demonstra... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference8 Quantitative thresholds for the FS phenotype vary across studies and recording conditions, partly reflecting genuine biological differences. PV interneuron firing properties vary systematically across cortical areas, with differences in maximum firing rate, input resistance, and spike width reflecting area-specific computational demands 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference9. Computational modeling of PV interneurons has demonstra... -
3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference0 Quantitative thresholds for the FS phenotype vary across studies and recording conditions, partly reflecting genuine biological differences. PV interneuron firing properties vary systematically across cortical areas, with differences in maximum firing rate, input resistance, and spike width reflecting area-specific computational demands 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference1. Computational modeling of PV interneurons has demonstra...
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3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference2 The principal molecular engine of fast-spiking is the Kv3 family of voltage-gated potassium channels. Kv3 channels are uniquely associated with the ability of neurons to fire at rates up to 1,000 Hz, owing to fast activation at depolarized potentials and unusually rapid deactivation 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference3. In hippocampal basket cells, the fast delayed rectifier current mediated by Kv3 channels constitutes 58% of to...
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3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference4 The principal molecular engine of fast-spiking is the Kv3 family of voltage-gated potassium channels. Kv3 channels are uniquely associated with the ability of neurons to fire at rates up to 1,000 Hz, owing to fast activation at depolarized potentials and unusually rapid deactivation 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference5. In hippocampal basket cells, the fast delayed rectifier current mediated by Kv3 channels constitutes 58% of to...
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3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference6 The principal molecular engine of fast-spiking is the Kv3 family of voltage-gated potassium channels. Kv3 channels are uniquely associated with the ability of neurons to fire at rates up to 1,000 Hz, owing to fast activation at depolarized potentials and unusually rapid deactivation 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference7. In hippocampal basket cells, the fast delayed rectifier current mediated by Kv3 channels constitutes 58% of to...
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3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference8 Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference9. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference0. Compartment-specific ro... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference1 Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference2. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference3. Compartment-specific ro... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference4 Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference5. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference6. Compartment-specific ro... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference7 Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference8. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference9. Compartment-specific ro... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference0 Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference1. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference2. Compartment-specific ro... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference3 Whether individual Kv3 subunit knockouts substantially impair the FS phenotype has been addressed with contrasting results that resolve into a model of layered redundancy. Kv3.1 knockout mice show only moderate impairment of fast-spiking in reticular thalamic nucleus neurons, with a modest increase in AP duration and reduction in repolarization rate, suggesting compensation by other Kv3 subunits [Kaczmarek2017channe... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference4 Whether individual Kv3 subunit knockouts substantially impair the FS phenotype has been addressed with contrasting results that resolve into a model of layered redundancy. Kv3.1 knockout mice show only moderate impairment of fast-spiking in reticular thalamic nucleus neurons, with a modest increase in AP duration and reduction in repolarization rate, suggesting compensation by other Kv3 subunits [Kaczmarek2017channe... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference5 Whether individual Kv3 subunit knockouts substantially impair the FS phenotype has been addressed with contrasting results that resolve into a model of layered redundancy. Kv3.1 knockout mice show only moderate impairment of fast-spiking in reticular thalamic nucleus neurons, with a modest increase in AP duration and reduction in repolarization rate, suggesting compensation by other Kv3 subunits [Kaczmarek2017channe... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference6 Whether individual Kv3 subunit knockouts substantially impair the FS phenotype has been addressed with contrasting results that resolve into a model of layered redundancy. Kv3.1 knockout mice show only moderate impairment of fast-spiking in reticular thalamic nucleus neurons, with a modest increase in AP duration and reduction in repolarization rate, suggesting compensation by other Kv3 subunits [Kaczmarek2017channe... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference7 The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference8. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference9 The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference0. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference1 The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference2. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference3 The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference4. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference5 The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference6. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference7 Impact of individual Kv3 channel subunit knockouts on the fast-spiking phenotype. (A) Relative action potential duration in wild-type versus Kv3.1 KO neurons (21% increase; reticular thalamic nucleus, 34°C). Kv3.2 KO data (deep cortical layers) are qualitative only. (B) Relative repolarization rate showing 30% reduction in Kv3.1 KO. Kv3.2 KO impairment is layer-specific. (C) Schematic of the redundancy model: layer-... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference8 Impact of individual Kv3 channel subunit knockouts on the fast-spiking phenotype. (A) Relative action potential duration in wild-type versus Kv3.1 KO neurons (21% increase; reticular thalamic nucleus, 34°C). Kv3.2 KO data (deep cortical layers) are qualitative only. (B) Relative repolarization rate showing 30% reduction in Kv3.1 KO. Kv3.2 KO impairment is layer-specific. (C) Schematic of the redundancy model: layer-... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference9 Impact of individual Kv3 channel subunit knockouts on the fast-spiking phenotype. (A) Relative action potential duration in wild-type versus Kv3.1 KO neurons (21% increase; reticular thalamic nucleus, 34°C). Kv3.2 KO data (deep cortical layers) are qualitative only. (B) Relative repolarization rate showing 30% reduction in Kv3.1 KO. Kv3.2 KO impairment is layer-specific. (C) Schematic of the redundancy model: layer-... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference0 Impact of individual Kv3 channel subunit knockouts on the fast-spiking phenotype. (A) Relative action potential duration in wild-type versus Kv3.1 KO neurons (21% increase; reticular thalamic nucleus, 34°C). Kv3.2 KO data (deep cortical layers) are qualitative only. (B) Relative repolarization rate showing 30% reduction in Kv3.1 KO. Kv3.2 KO impairment is layer-specific. (C) Schematic of the redundancy model: layer-... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference1 Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer’s mice, producing gamma-frequency-specific network hyperexcitability 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference2. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer’s disease, and th... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference3 Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer’s mice, producing gamma-frequency-specific network hyperexcitability 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference4. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer’s disease, and th... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference5 Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer’s mice, producing gamma-frequency-specific network hyperexcitability 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference6. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer’s disease, and th... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference7 Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer’s mice, producing gamma-frequency-specific network hyperexcitability 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference8. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer’s disease, and th... -
1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference9 Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer’s mice, producing gamma-frequency-specific network hyperexcitability 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference0. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer’s disease, and th... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference1 Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer’s mice, producing gamma-frequency-specific network hyperexcitability 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference2. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer’s disease, and th... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference3 While Kv3 channels enable fast spike repolarization, Nav1.1 (encoded by Scn1a) ensures reliable action potential initiation during sustained high-frequency firing. Nav1.1 is clustered at the axon initial segment of PV interneurons, where high sodium channel density enables low-threshold, reliable AP initiation 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference4. Loss-of-function mutations in SCN1A cause Dravet syndrome thro... -
2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}
sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference5 While Kv3 channels enable fast spike repolarization, Nav1.1 (encoded by Scn1a) ensures reliable action potential initiation during sustained high-frequency firing. Nav1.1 is clustered at the axon initial segment of PV interneurons, where high sodium channel density enables low-threshold, reliable AP initiation 2CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 3CitationThe fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...content/05_intrinsic_electrophysiology.md:line 8Open reference, 1CitationThe molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}sec-molecular-identity— do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...content/05_intrinsic_electrophysiology.md:line 4Open reference6. Loss-of-function mutations in SCN1A cause Dravet syndrome thro... -
... 46 additional anchors in refs_json
References
- [Kawaguchi1993physiological] “The molecular markers that define PV interneurons — Kv3 potassium channels, Nav1.1 sodium channels, and their associated gene regulatory programs described in {ref}`sec-molecular-identity` — do not merely label these cells but endow them with a distinctive physiological signature. The fast-spiking (FS) phenotype, first formally characterized in rat neostriatum [Kawaguchi1993physiological], represents the functional...”
- [Tremblay2016gabaergic] “The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...”
- [Pelkey2017hippocampal] “The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...”
- [Gouwens2020integrated] “The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...”
- [Scala2021phenotypic] “The fast-spiking phenotype is defined by brief action potentials with large, rapid afterhyperpolarizations (AHPs); the capacity for sustained high-frequency firing with little spike-frequency adaptation; low input resistance; and a fast membrane time constant [Tremblay2016gabaergic, Pelkey2017hippocampal, Kawaguchi1993physiological]. These properties distinguish PV interneurons from all other cortical neuron classes...”
- [Wang2010neurophysiological] “The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering [Wang2010neurophysiological], making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...”
- [Buzsaki2012mechanisms] “The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering [Wang2010neurophysiological], making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...”
- [Stark2013inhibition] “The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering [Wang2010neurophysiological], making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...”
- [Lee2014parvalbumin] “The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering [Wang2010neurophysiological], making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...”
- [Guthman2020cell] “The functional consequences of these biophysical properties are profound. The fast membrane time constant and low input resistance enable PV interneurons to track synaptic input with minimal temporal filtering [Wang2010neurophysiological], making them ideally suited to relay rapid fluctuations in network activity. This temporal fidelity is essential for generating gamma-frequency oscillations (30–80 Hz), where FS me...”
- [Clatot2024structurally] “Quantitative thresholds for the FS phenotype vary across studies and recording conditions, partly reflecting genuine biological differences. PV interneuron firing properties vary systematically across cortical areas, with differences in maximum firing rate, input resistance, and spike width reflecting area-specific computational demands [Tremblay2016gabaergic]. Computational modeling of PV interneurons has demonstra...”
- [Zaitsev2009interneuron] “Quantitative thresholds for the FS phenotype vary across studies and recording conditions, partly reflecting genuine biological differences. PV interneuron firing properties vary systematically across cortical areas, with differences in maximum firing rate, input resistance, and spike width reflecting area-specific computational demands [Tremblay2016gabaergic]. Computational modeling of PV interneurons has demonstra...”
- [Runyan2010response] “Quantitative thresholds for the FS phenotype vary across studies and recording conditions, partly reflecting genuine biological differences. PV interneuron firing properties vary systematically across cortical areas, with differences in maximum firing rate, input resistance, and spike width reflecting area-specific computational demands [Tremblay2016gabaergic]. Computational modeling of PV interneurons has demonstra...”
- [Kaczmarek2017channels] “The principal molecular engine of fast-spiking is the Kv3 family of voltage-gated potassium channels. Kv3 channels are uniquely associated with the ability of neurons to fire at rates up to 1,000 Hz, owing to fast activation at depolarized potentials and unusually rapid deactivation [Kaczmarek2017channels]. In hippocampal basket cells, the fast delayed rectifier current mediated by Kv3 channels constitutes 58% of to...”
- [Martina1998functional] “The principal molecular engine of fast-spiking is the Kv3 family of voltage-gated potassium channels. Kv3 channels are uniquely associated with the ability of neurons to fire at rates up to 1,000 Hz, owing to fast activation at depolarized potentials and unusually rapid deactivation [Kaczmarek2017channels]. In hippocampal basket cells, the fast delayed rectifier current mediated by Kv3 channels constitutes 58% of to...”
- [Chow1999channel] “The principal molecular engine of fast-spiking is the Kv3 family of voltage-gated potassium channels. Kv3 channels are uniquely associated with the ability of neurons to fire at rates up to 1,000 Hz, owing to fast activation at depolarized potentials and unusually rapid deactivation [Kaczmarek2017channels]. In hippocampal basket cells, the fast delayed rectifier current mediated by Kv3 channels constitutes 58% of to...”
- [Goldberg2005specific] “Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability [Goldberg2005specific]. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished [Goldberg2005specific]. Compartment-specific ro...”
- [Rowan2014distinct] “Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability [Goldberg2005specific]. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished [Goldberg2005specific]. Compartment-specific ro...”
- [Manseau2010desynchronization] “Kv3 channels serve an equally critical role at presynaptic terminals. Synaptically localized Kv3 channels keep action potentials brief at FS cell boutons, limiting calcium influx and release probability [Goldberg2005specific]. In Kv3.1/Kv3.2 double knockout mice, the normal enhancement of spike-evoked GABA release by TEA (approximately 2-fold in wild-type) is abolished [Goldberg2005specific]. Compartment-specific ro...”
- [Lau2000impaired] “Whether individual Kv3 subunit knockouts substantially impair the FS phenotype has been addressed with contrasting results that resolve into a model of layered redundancy. Kv3.1 knockout mice show only moderate impairment of fast-spiking in reticular thalamic nucleus neurons, with a modest increase in AP duration and reduction in repolarization rate, suggesting compensation by other Kv3 subunits [Kaczmarek2017channe...”
- [Du1996developmental] “The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period [Du1996developmental]. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon...”
- [Okaty2009transcriptional] “The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period [Du1996developmental]. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon...”
- [Doischer2008postnatal] “The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period [Du1996developmental]. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon...”
- [Gu2018balanced] “The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period [Du1996developmental]. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon...”
- [Stevens2021ankyrin] “The developmental expression of Kv3.1 follows a timeline that parallels maturation of FS properties, with expression beginning in the first postnatal week and increasing through the critical period [Du1996developmental]. This trajectory is mirrored at the transcriptomic level: the FS phenotype emerges through coordinated regulation of thousands of genes between P7 and P40, including upregulation of Kv3 channels alon...”
- [Olah2022biophysical] “Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, producing gamma-frequency-specific network hyperexcitability [Olah2022biophysical]. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer's disease, and th...”
- [Hijazi2023fast] “Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, producing gamma-frequency-specific network hyperexcitability [Olah2022biophysical]. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer's disease, and th...”
- [Kourdougli2023improvement] “Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, producing gamma-frequency-specific network hyperexcitability [Olah2022biophysical]. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer's disease, and th...”
- [Jiang2016involvement] “Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, producing gamma-frequency-specific network hyperexcitability [Olah2022biophysical]. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer's disease, and th...”
- [Nelson2015excitatory] “Kv3 channels are also a convergence point for pathology. Biophysical modulation of Kv3 channels — without changes in mRNA or protein expression — dampens PV interneuron excitability in young 5xFAD Alzheimer's mice, producing gamma-frequency-specific network hyperexcitability [Olah2022biophysical]. PV interneurons display altered AP firing before neighboring excitatory neurons in prodromal Alzheimer's disease, and th...”
- [Ogiwara2007nav] “While Kv3 channels enable fast spike repolarization, Nav1.1 (encoded by *Scn1a*) ensures reliable action potential initiation during sustained high-frequency firing. Nav1.1 is clustered at the axon initial segment of PV interneurons, where high sodium channel density enables low-threshold, reliable AP initiation [Ogiwara2007nav, Clark2009electrogenic]. Loss-of-function mutations in *SCN1A* cause Dravet syndrome thro...”
- [Clark2009electrogenic] “While Kv3 channels enable fast spike repolarization, Nav1.1 (encoded by *Scn1a*) ensures reliable action potential initiation during sustained high-frequency firing. Nav1.1 is clustered at the axon initial segment of PV interneurons, where high sodium channel density enables low-threshold, reliable AP initiation [Ogiwara2007nav, Clark2009electrogenic]. Loss-of-function mutations in *SCN1A* cause Dravet syndrome thro...”
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