Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested

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Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested

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  • 1Citationpaper:paper-53c8505de50fThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...

  • 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...

  • 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...

  • 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 9Citationpaper:1f98e15e-de06-42f7-9da8-1faa69bba835The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 10Citationpaper:paper-pm-34616062The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference0 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference1 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference2 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference3 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference4 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference5 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference6 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference7 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference8 The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...

  • 2Citationpaper:paper-aaf84aa85982The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference9 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference0. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference1 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference2. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference3 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference4. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference5 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference6. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference7 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference8. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 3Citationpaper:paper-ad1611a9283aThe preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference9 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference0. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference1 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference2. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference3 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference4. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference5 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference6. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference7 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference8. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 4Citationpaper:paper-560189f9d2b5The preceding sections have traced parvalbumin interneuron biology from molecular identity through developmental specification, morphological diversity, intrinsic electrophysiology, synaptic physiology, circuit motifs, in vivo dynamics, regional specialization, oscillatory function, species translation, disease models, and computational frameworks. Each section necessarily focused on its own evidence cluster, but th...content/13_cross_cluster_synthesis.md:line 4Open reference9 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference0. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference1 Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference2. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...

  • 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference3 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference4. This phenotype is directly traceable to t...

  • 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference5 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference6. This phenotype is directly traceable to t...

  • 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference7 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference8. This phenotype is directly traceable to t...

  • 5Citationpaper:paper-35a6c66c3e2eThe defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference9 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference0. This phenotype is directly traceable to t...

  • 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference1 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference2. This phenotype is directly traceable to t...

  • 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference3 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference4. This phenotype is directly traceable to t...

  • 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference5 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference6. This phenotype is directly traceable to t...

  • 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference7 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference8. This phenotype is directly traceable to t...

  • 6Citationpaper:paper-591943f1ad14The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference9 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference0. This phenotype is directly traceable to t...

  • 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference1 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference2. This phenotype is directly traceable to t...

  • 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference3 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference4. This phenotype is directly traceable to t...

  • 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference5 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference6. This phenotype is directly traceable to t...

  • 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference7 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference8. This phenotype is directly traceable to t...

  • 7Citationpaper:paper-pm-33186530The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference9 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference0. This phenotype is directly traceable to t...

  • 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference1 The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference2. This phenotype is directly traceable to t...

  • 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference3 The preferential targeting of perisomatic compartments by PV basket cells — soma, proximal dendrites, and axon initial segment (for chandelier cells) — is confirmed by anatomical, electrophysiological, and connectomic studies spanning decades 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference4. PV synapses exhibit short-term depression during repetitive activation, rapid IPSC ki...

  • 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference5 The preferential targeting of perisomatic compartments by PV basket cells — soma, proximal dendrites, and axon initial segment (for chandelier cells) — is confirmed by anatomical, electrophysiological, and connectomic studies spanning decades 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference6. PV synapses exhibit short-term depression during repetitive activation, rapid IPSC ki...

  • 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference7 The preferential targeting of perisomatic compartments by PV basket cells — soma, proximal dendrites, and axon initial segment (for chandelier cells) — is confirmed by anatomical, electrophysiological, and connectomic studies spanning decades 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference8. PV synapses exhibit short-term depression during repetitive activation, rapid IPSC ki...

  • 8Citationpaper:paper-4dfe44516146The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference9 The preferential targeting of perisomatic compartments by PV basket cells — soma, proximal dendrites, and axon initial segment (for chandelier cells) — is confirmed by anatomical, electrophysiological, and connectomic studies spanning decades 9Citationpaper:1f98e15e-de06-42f7-9da8-1faa69bba835The defining molecular signature of PV interneurons — co-expression of parvalbumin (Pvalb), Kv3-family potassium channels (Kcnc1/2), Nav1.1 (Scn1a), and ErbB4 (see {ref}sec-molecular-identity) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...content/13_cross_cluster_synthesis.md:line 101Open reference0. PV synapses exhibit short-term depression during repetitive activation, rapid IPSC ki...

  • ... 164 additional anchors in refs_json

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  6. [Okaty2009transcriptional] paper:paper-591943f1ad14 “The defining molecular signature of PV interneurons — co-expression of parvalbumin (*Pvalb*), Kv3-family potassium channels (*Kcnc1/2*), Nav1.1 (*Scn1a*), and ErbB4 (see {ref}`sec-molecular-identity`) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...”
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  9. [Yao2023high] paper:1f98e15e-de06-42f7-9da8-1faa69bba835 “The defining molecular signature of PV interneurons — co-expression of parvalbumin (*Pvalb*), Kv3-family potassium channels (*Kcnc1/2*), Nav1.1 (*Scn1a*), and ErbB4 (see {ref}`sec-molecular-identity`) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...”
  10. [Bakken2021comparative] paper:paper-pm-34616062 “The defining molecular signature of PV interneurons — co-expression of parvalbumin (*Pvalb*), Kv3-family potassium channels (*Kcnc1/2*), Nav1.1 (*Scn1a*), and ErbB4 (see {ref}`sec-molecular-identity`) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...”
  11. [Unknown2021multimodal] paper:paper-pm-34616075 “The defining molecular signature of PV interneurons — co-expression of parvalbumin (*Pvalb*), Kv3-family potassium channels (*Kcnc1/2*), Nav1.1 (*Scn1a*), and ErbB4 (see {ref}`sec-molecular-identity`) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...”
  12. [Feng2025cortical] paper:paper-ea2ec5551114 “The defining molecular signature of PV interneurons — co-expression of parvalbumin (*Pvalb*), Kv3-family potassium channels (*Kcnc1/2*), Nav1.1 (*Scn1a*), and ErbB4 (see {ref}`sec-molecular-identity`) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...”
  13. [Nehme2024genomic] paper:paper-7e18e89cf496 “The defining molecular signature of PV interneurons — co-expression of parvalbumin (*Pvalb*), Kv3-family potassium channels (*Kcnc1/2*), Nav1.1 (*Scn1a*), and ErbB4 (see {ref}`sec-molecular-identity`) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...”
  14. [Lim2018development] paper:paper-11e0bb0a904f “The defining molecular signature of PV interneurons — co-expression of parvalbumin (*Pvalb*), Kv3-family potassium channels (*Kcnc1/2*), Nav1.1 (*Scn1a*), and ErbB4 (see {ref}`sec-molecular-identity`) — has been independently confirmed by every major single-cell transcriptomic atlas from the earliest studies through the most recent million-cell datasets [Paul2017transcriptional, Okaty2009transcriptional, Gouwens2020...”
  15. [Peng2021morphological] paper:paper-aa79acad2563 “Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies [Gouwens2020integrated, Yao2021taxonomy, Peng2021morphological]. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...”
  16. [Soorajkumar2025mapping] paper:paper-5f543ca72bb1 “Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies [Gouwens2020integrated, Yao2021taxonomy, Peng2021morphological]. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...”
  17. [Scala2021phenotypic] paper:paper-be132b319290 “Within this consensus, finer-grained molecular subdivisions show progressively less replication. The Pvalb Vipr2 transcriptomic type, corresponding to chandelier cells, is robustly reproduced across studies [Gouwens2020integrated, Yao2021taxonomy, Peng2021morphological]. However, the number and boundaries of basket cell subtypes vary substantially between atlases, with estimates ranging from 3 supertypes containing...”
  18. [Hu2018complementary] paper:paper-e022e0b961a0 “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  19. [Carter2009sodium] paper:paper-5913a3633195 “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  20. [Tai2014impaired] paper:paper-855d0bdbad3b “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  21. [Parameshwaran2001expression] paper:paper-f2a5716f0156 “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  22. [Lau2000impaired] paper:paper-08e60421a6c7 “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  23. [Yamakawa2011molecular] paper:paper-8c5838461042 “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  24. [Favero2018transient] paper:paper-26eb18eb4bf8 “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  25. [Wengert2026impaired] paper:paper-727b6f995460 “The fast-spiking electrophysiological signature of PV interneurons — narrow action potentials, high maximal firing rates (often exceeding 200 Hz), minimal spike-frequency adaptation, and low input resistance — is among the most consistently replicated findings in cellular neuroscience [Hu2018complementary, Carter2009sodium, Okaty2009transcriptional, Bartholome2020composite]. This phenotype is directly traceable to t...”
  26. [Hage2022synaptic] paper:paper-14e5fb681943 “The preferential targeting of perisomatic compartments by PV basket cells — soma, proximal dendrites, and axon initial segment (for chandelier cells) — is confirmed by anatomical, electrophysiological, and connectomic studies spanning decades [Tremblay2016gabaergic, Pelkey2017hippocampal, Hage2022synaptic, Bartholome2020composite]. PV synapses exhibit short-term depression during repetitive activation, rapid IPSC ki...”

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