Synthesis and Evidence Assessment

Synthesis and Evidence Assessment

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• ^{1Citationpaper:paper-f74447d3e5d5The computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference} The computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference} The computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...

• ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference} The computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference} Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field’s most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference} demonstrated three subtypes of layer 5 SST interneurons with distinct elect...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference} Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field’s most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference} demonstrated three subtypes of layer 5 SST interneurons with distinct elect...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference} Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field’s most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference} demonstrated three subtypes of layer 5 SST interneurons with distinct elect...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference} Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field’s most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}0 demonstrated three subtypes of layer 5 SST interneurons with distinct elect...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}1 Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field’s most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}2 demonstrated three subtypes of layer 5 SST interneurons with distinct elect...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}3 Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field’s most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}4 demonstrated three subtypes of layer 5 SST interneurons with distinct elect...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}5 The role of non-Martinotti SST neurons in thalamocortical feedforward inhibition represents a second independently replicated finding. ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}6 first characterized these cells in layer 4 barrel cortex, and ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}7 subsequently showed that the non-Martinotti subtype forms a specific circuit motif receiving thalamic input and providing local inhibition ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}8. ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}9 confirmed that Mar...

• ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}0 The role of non-Martinotti SST neurons in thalamocortical feedforward inhibition represents a second independently replicated finding. ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}1 first characterized these cells in layer 4 barrel cortex, and ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}2 subsequently showed that the non-Martinotti subtype forms a specific circuit motif receiving thalamic input and providing local inhibition ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}3. ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}4 confirmed that Mar...

• ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}5 The role of non-Martinotti SST neurons in thalamocortical feedforward inhibition represents a second independently replicated finding. ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}6 first characterized these cells in layer 4 barrel cortex, and ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}7 subsequently showed that the non-Martinotti subtype forms a specific circuit motif receiving thalamic input and providing local inhibition ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}8. ^{3Citationpaper:paper-00de1a2c593eThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}9 confirmed that Mar...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}0 The role of non-Martinotti SST neurons in thalamocortical feedforward inhibition represents a second independently replicated finding. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}1 first characterized these cells in layer 4 barrel cortex, and ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}2 subsequently showed that the non-Martinotti subtype forms a specific circuit motif receiving thalamic input and providing local inhibition ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}3. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}4 confirmed that Mar...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}5 The role of non-Martinotti SST neurons in thalamocortical feedforward inhibition represents a second independently replicated finding. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}6 first characterized these cells in layer 4 barrel cortex, and ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}7 subsequently showed that the non-Martinotti subtype forms a specific circuit motif receiving thalamic input and providing local inhibition ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}8. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}9 confirmed that Mar...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}0 The role of non-Martinotti SST neurons in thalamocortical feedforward inhibition represents a second independently replicated finding. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}1 first characterized these cells in layer 4 barrel cortex, and ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}2 subsequently showed that the non-Martinotti subtype forms a specific circuit motif receiving thalamic input and providing local inhibition ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}3. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}4 confirmed that Mar...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}5 The role of non-Martinotti SST neurons in thalamocortical feedforward inhibition represents a second independently replicated finding. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}6 first characterized these cells in layer 4 barrel cortex, and ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}7 subsequently showed that the non-Martinotti subtype forms a specific circuit motif receiving thalamic input and providing local inhibition ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}8. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}9 confirmed that Mar...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}0 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}1 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}2. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}3 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}4 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}5. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}6 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}7 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}8. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}9 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}0 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}1. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}2 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}3 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}4. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}5 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}6 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}7. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}8 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}9 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}0. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}1 A third robustly replicated finding concerns the reduction of SST-related gene expression in schizophrenia. ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}2 identified somatostatin interneurons as a key cell type in the cellular etiology of schizophrenia through GWAS combined with single-cell genomics ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}3. Meta-analyses of postmortem transcriptomic studies independently confirm altered expression of GABA-related genes, including markers assoc...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}4 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}5 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}6 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}7 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}8 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}9 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}0 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}1 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}2 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}3 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}4 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}5 Evidence quality assessment for eight major SST interneuron functional claims. Bar color indicates replication status: independently replicated by two or more laboratories (green), contested or conflicting evidence (pink), or supported only by computational models (gray). Right columns indicate evidence type and scale. Three of eight claims meet the standard of independent replication; four are contested; one rests...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}6 Importantly, the pattern of evidence strength maps onto a methodological gradient. Findings based on anatomy and electrophysiology (subtype classification, connectivity) tend to be the most robust, because these methods produce direct observations of structure and cellular properties. Findings based on optogenetic manipulation (surround suppression, gain control) are more contested, in part because optogenetics prod...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}7 Importantly, the pattern of evidence strength maps onto a methodological gradient. Findings based on anatomy and electrophysiology (subtype classification, connectivity) tend to be the most robust, because these methods produce direct observations of structure and cellular properties. Findings based on optogenetic manipulation (surround suppression, gain control) are more contested, in part because optogenetics prod...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}8 Importantly, the pattern of evidence strength maps onto a methodological gradient. Findings based on anatomy and electrophysiology (subtype classification, connectivity) tend to be the most robust, because these methods produce direct observations of structure and cellular properties. Findings based on optogenetic manipulation (surround suppression, gain control) are more contested, in part because optogenetics prod...

• ^{4Citationpaper:paper-c57fcb1aef2aNot all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}9 Importantly, the pattern of evidence strength maps onto a methodological gradient. Findings based on anatomy and electrophysiology (subtype classification, connectivity) tend to be the most robust, because these methods produce direct observations of structure and cellular properties. Findings based on optogenetic manipulation (surround suppression, gain control) are more contested, in part because optogenetics prod...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}0 Importantly, the pattern of evidence strength maps onto a methodological gradient. Findings based on anatomy and electrophysiology (subtype classification, connectivity) tend to be the most robust, because these methods produce direct observations of structure and cellular properties. Findings based on optogenetic manipulation (surround suppression, gain control) are more contested, in part because optogenetics prod...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}1 ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}2 provided the foundational demonstration that SST interneurons in mouse visual cortex mediate surround suppression through a neural circuit for spatial summation ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}3. Optogenetic activation of SST neurons enhanced surround suppression while their inactivation reduced it, establishing a clear causal link. This finding was rapidly incorporated into textbooks and reviews as a canonical function o...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}4 ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}5 provided the foundational demonstration that SST interneurons in mouse visual cortex mediate surround suppression through a neural circuit for spatial summation ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}6. Optogenetic activation of SST neurons enhanced surround suppression while their inactivation reduced it, establishing a clear causal link. This finding was rapidly incorporated into textbooks and reviews as a canonical function o...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}7 Evolution of evidence for SST-mediated surround suppression from initial demonstration (2012) through mechanistic refinement, cross-modal extension, and methodological challenge (2025). The narrative shifted from “SST neurons cause surround suppression” to “SST neurons contribute to surround suppression among other mechanisms.” Metric definitions vary across entries; values should be compared qualitatively rather th...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}8 Evolution of evidence for SST-mediated surround suppression from initial demonstration (2012) through mechanistic refinement, cross-modal extension, and methodological challenge (2025). The narrative shifted from “SST neurons cause surround suppression” to “SST neurons contribute to surround suppression among other mechanisms.” Metric definitions vary across entries; values should be compared qualitatively rather th...

• ^{5Citationpaper:paper-c7076ba88e47Not all claims in the SST literature are equal. A small number of findings have been independently replicated across laboratories using complementary methods, and these form the field's most secure foundation. The distinction between Martinotti and non-Martinotti SST interneurons represents the strongest convergence in the field. [Nigro2018] demonstrated three subtypes of layer 5 SST interneurons with distinct elect...content/13_synthesis.md:line 7Open reference}9 Evolution of evidence for SST-mediated surround suppression from initial demonstration (2012) through mechanistic refinement, cross-modal extension, and methodological challenge (2025). The narrative shifted from “SST neurons cause surround suppression” to “SST neurons contribute to surround suppression among other mechanisms.” Metric definitions vary across entries; values should be compared qualitatively rather th...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}00 Evolution of evidence for SST-mediated surround suppression from initial demonstration (2012) through mechanistic refinement, cross-modal extension, and methodological challenge (2025). The narrative shifted from “SST neurons cause surround suppression” to “SST neurons contribute to surround suppression among other mechanisms.” Metric definitions vary across entries; values should be compared qualitatively rather th...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}01 Within a year of the original demonstration, ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}02 showed that SST and PV interneurons make differential, contrast-dependent contributions to surround suppression — SST-mediated suppression is contrast-invariant while PV-mediated suppression is contrast-dependent ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}03. This refinement suggested that surround suppression is not a single SST-dependent mechanism but involves at least two interneuron-...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}04 Within a year of the original demonstration, ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}05 showed that SST and PV interneurons make differential, contrast-dependent contributions to surround suppression — SST-mediated suppression is contrast-invariant while PV-mediated suppression is contrast-dependent ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}06. This refinement suggested that surround suppression is not a single SST-dependent mechanism but involves at least two interneuron-...

• ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}07 Within a year of the original demonstration, ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}08 showed that SST and PV interneurons make differential, contrast-dependent contributions to surround suppression — SST-mediated suppression is contrast-invariant while PV-mediated suppression is contrast-dependent ^{2Citationpaper:paper-5d546dd2545aThe computational models examined in {ref}sec-computational-models formalized a set of hypotheses about SST interneuron function — from inhibition-stabilized networks to predictive coding frameworks. Each model necessarily made simplifying assumptions about what SST neurons are and what they do. This section asks a different question: which of those assumptions, and which of the broader claims that pervade the SST...content/13_synthesis.md:line 3Open reference}09. This refinement suggested that surround suppression is not a single SST-dependent mechanism but involves at least two interneuron-...

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