A Molecular Taxonomy of Cortical Inhibitory Neurons

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Source: https://github.com/AllenNeuralDynamics/ComputationReviewInhibitory/blob/934e0675cc6d5ffd9978a4a9883b31166ce000e2/content/02_classification.md

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^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference} Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...
^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference} Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...
^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference} Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...
^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference} Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...
^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference} Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8 The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. ^{2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 The marker-based scheme, however, was always an approximation. Co-expression of markers complicates clean boundaries — in mouse cortex, significant colocalization of SST and calretinin occurs in interneurons that do not fit neatly into single-marker categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1. Across species, the correspondence breaks down further: primate cortical interneurons exhibit electrophysiological properties that differ systematic...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 The marker-based scheme, however, was always an approximation. Co-expression of markers complicates clean boundaries — in mouse cortex, significant colocalization of SST and calretinin occurs in interneurons that do not fit neatly into single-marker categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3. Across species, the correspondence breaks down further: primate cortical interneurons exhibit electrophysiological properties that differ systematic...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4 The marker-based scheme, however, was always an approximation. Co-expression of markers complicates clean boundaries — in mouse cortex, significant colocalization of SST and calretinin occurs in interneurons that do not fit neatly into single-marker categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5. Across species, the correspondence breaks down further: primate cortical interneurons exhibit electrophysiological properties that differ systematic...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 Single-cell RNA sequencing (scRNA-seq) transformed interneuron classification from marker-based binning into data-driven taxonomy. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7 identified 47 molecularly distinct subclasses in the somatosensory cortex, demonstrating that transcriptomic diversity vastly exceeds what marker-based schemes had captured ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 extended this approach across the mouse neocortex, revealing a hierarchical...
^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 Single-cell RNA sequencing (scRNA-seq) transformed interneuron classification from marker-based binning into data-driven taxonomy. ^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1 identified 47 molecularly distinct subclasses in the somatosensory cortex, demonstrating that transcriptomic diversity vastly exceeds what marker-based schemes had captured ^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2. ^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3 extended this approach across the mouse neocortex, revealing a hierarchical...
^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4 Single-cell RNA sequencing (scRNA-seq) transformed interneuron classification from marker-based binning into data-driven taxonomy. ^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5 identified 47 molecularly distinct subclasses in the somatosensory cortex, demonstrating that transcriptomic diversity vastly exceeds what marker-based schemes had captured ^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6. ^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7 extended this approach across the mouse neocortex, revealing a hierarchical...
^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8 Single-cell RNA sequencing (scRNA-seq) transformed interneuron classification from marker-based binning into data-driven taxonomy. ^{3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 identified 47 molecularly distinct subclasses in the somatosensory cortex, demonstrating that transcriptomic diversity vastly exceeds what marker-based schemes had captured ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1 extended this approach across the mouse neocortex, revealing a hierarchical...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 Single-cell RNA sequencing (scRNA-seq) transformed interneuron classification from marker-based binning into data-driven taxonomy. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3 identified 47 molecularly distinct subclasses in the somatosensory cortex, demonstrating that transcriptomic diversity vastly exceeds what marker-based schemes had captured ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5 extended this approach across the mouse neocortex, revealing a hierarchical...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 Single-cell RNA sequencing (scRNA-seq) transformed interneuron classification from marker-based binning into data-driven taxonomy. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7 identified 47 molecularly distinct subclasses in the somatosensory cortex, demonstrating that transcriptomic diversity vastly exceeds what marker-based schemes had captured ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 extended this approach across the mouse neocortex, revealing a hierarchical...
^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8 Hierarchical classification of cortical GABAergic interneurons. Five cardinal subclasses (Pvalb, Sst, Vip, Lamp5, Sncg) are resolved at the top level by scRNA-seq and MERFISH. Each subclass contains multiple supertypes (middle level), which further subdivide into fine transcriptomic types (bottom level, ~100+ in mouse cortex). Cross-modal concordance is strong at the subclass level (transcriptomic subclass...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 Hierarchical classification of cortical GABAergic interneurons. Five cardinal subclasses (Pvalb, Sst, Vip, Lamp5, Sncg) are resolved at the top level by scRNA-seq and MERFISH. Each subclass contains multiple supertypes (middle level), which further subdivide into fine transcriptomic types (bottom level, ~100+ in mouse cortex). Cross-modal concordance is strong at the subclass level (transcriptomic subclass...
^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 Hierarchical classification of cortical GABAergic interneurons. Five cardinal subclasses (Pvalb, Sst, Vip, Lamp5, Sncg) are resolved at the top level by scRNA-seq and MERFISH. Each subclass contains multiple supertypes (middle level), which further subdivide into fine transcriptomic types (bottom level, ~100+ in mouse cortex). Cross-modal concordance is strong at the subclass level (transcriptomic subclass...
^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1 Hierarchical classification of cortical GABAergic interneurons. Five cardinal subclasses (Pvalb, Sst, Vip, Lamp5, Sncg) are resolved at the top level by scRNA-seq and MERFISH. Each subclass contains multiple supertypes (middle level), which further subdivide into fine transcriptomic types (bottom level, ~100+ in mouse cortex). Cross-modal concordance is strong at the subclass level (transcriptomic subclass...
^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 The strongest test of a molecular taxonomy is whether it predicts properties measured by independent modalities. Multi-modal studies combining transcriptomics with electrophysiology and morphology — Patch-seq — have revealed both encouraging concordance and instructive failures. ^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3 characterized the morpho-electric and transcriptomic properties of over 4,000 neurons in mouse visual cortex, finding that t...
^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4 The strongest test of a molecular taxonomy is whether it predicts properties measured by independent modalities. Multi-modal studies combining transcriptomics with electrophysiology and morphology — Patch-seq — have revealed both encouraging concordance and instructive failures. ^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5 characterized the morpho-electric and transcriptomic properties of over 4,000 neurons in mouse visual cortex, finding that t...
^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 The strongest test of a molecular taxonomy is whether it predicts properties measured by independent modalities. Multi-modal studies combining transcriptomics with electrophysiology and morphology — Patch-seq — have revealed both encouraging concordance and instructive failures. ^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7 characterized the morpho-electric and transcriptomic properties of over 4,000 neurons in mouse visual cortex, finding that t...
^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8 The strongest test of a molecular taxonomy is whether it predicts properties measured by independent modalities. Multi-modal studies combining transcriptomics with electrophysiology and morphology — Patch-seq — have revealed both encouraging concordance and instructive failures. ^{5Citationpaper:paper-062fda557edfTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 characterized the morpho-electric and transcriptomic properties of over 4,000 neurons in mouse visual cortex, finding that t...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}0 The strongest test of a molecular taxonomy is whether it predicts properties measured by independent modalities. Multi-modal studies combining transcriptomics with electrophysiology and morphology — Patch-seq — have revealed both encouraging concordance and instructive failures. ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}1 characterized the morpho-electric and transcriptomic properties of over 4,000 neurons in mouse visual cortex, finding that t...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}2 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}3 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}4. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}5 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}6 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}7. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}8 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}9 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}00. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}01 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}02 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}03. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}04 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}05 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}06. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}07 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}08 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}09. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}10 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}11 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}12. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}13 A latent factor analysis of hippocampal interneurons exemplifies this tension: ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}14 found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories ^{1Citationpaper:paper-4dfe44516146Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 2Citationpaper:paper-pm-30382198Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 3Citationpaper:34a07597-2d6f-4552-b9cf-d2d11817f9f9Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference, 4Citationpaper:paper-6e5df2cb10baTranscriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — Pvalb, Sst, Vip, Lamp5, and Sncg — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...content/02_classification.md:line 3Open reference}15. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...
... 121 additional anchors in refs_json

References

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[Tasic2018] paper:paper-pm-30382198 “Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — *Pvalb*, *Sst*, *Vip*, *Lamp5*, and *Sncg* — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...”
[Rudy2011] paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9 “Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — *Pvalb*, *Sst*, *Vip*, *Lamp5*, and *Sncg* — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...”
[Zeisel2015] paper:paper-6e5df2cb10ba “Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — *Pvalb*, *Sst*, *Vip*, *Lamp5*, and *Sncg* — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...”
[Bugeon2022] paper:paper-062fda557edf “Transcriptomic profiling has, over the past decade, established a hierarchical classification of cortical GABAergic interneurons that resolves cardinal classes — *Pvalb*, *Sst*, *Vip*, *Lamp5*, and *Sncg* — with strong cross-modal concordance at the subclass level [Yao2021,Tasic2018,Rudy2011,Zeisel2015]. Yet the resolution of this classification depends fundamentally on the modality used to interrogate it, and withi...”
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[Kawaguchi2002] paper:paper-fcc95260f55c “The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. [Kawaguchi1996] demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...”
[Ma2006] paper:paper-45d28ae23ca2 “The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. [Kawaguchi1996] demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...”
[Xu2013] paper:paper-92bf23cf430e “The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. [Kawaguchi1996] demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...”
[DeFelipe1986] paper:paper-aa44cb3f3377 “The recognition that cortical GABAergic interneurons could be partitioned into non-overlapping classes using molecular markers preceded the transcriptomic era by decades. [Kawaguchi1996] demonstrated that calcium-binding proteins and neuropeptides define separate GABAergic neuron populations controlling distinct cortical circuits, establishing the framework of parvalbumin (PV), somatostatin (SST), and calretinin (CR...”
[Xu2006] paper:paper-c901caa79370 “The marker-based scheme, however, was always an approximation. Co-expression of markers complicates clean boundaries — in mouse cortex, significant colocalization of SST and calretinin occurs in interneurons that do not fit neatly into single-marker categories [Xu2006]. Across species, the correspondence breaks down further: primate cortical interneurons exhibit electrophysiological properties that differ systematic...”
[Povysheva2008] paper:paper-fe0179d0deb2 “The marker-based scheme, however, was always an approximation. Co-expression of markers complicates clean boundaries — in mouse cortex, significant colocalization of SST and calretinin occurs in interneurons that do not fit neatly into single-marker categories [Xu2006]. Across species, the correspondence breaks down further: primate cortical interneurons exhibit electrophysiological properties that differ systematic...”
[Krimer2005] paper:paper-c5fb827111ed “The marker-based scheme, however, was always an approximation. Co-expression of markers complicates clean boundaries — in mouse cortex, significant colocalization of SST and calretinin occurs in interneurons that do not fit neatly into single-marker categories [Xu2006]. Across species, the correspondence breaks down further: primate cortical interneurons exhibit electrophysiological properties that differ systematic...”
[Yuste2020] paper:paper-pm-32839617 “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Mao2024] paper:paper-367b1305876d “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Agmon2024] paper:paper-5d546dd2545a “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Lee2023a] paper:paper-37824669 “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Tasic2016] paper:paper-ed2a7f08ef35 “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Fan2018] paper:paper-6f7ca5613d15 “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Li2022] paper:paper-e6e509502b5a “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Franjic2022] paper:paper-c532b00b0abe “This hierarchical framework received community endorsement through a nomenclature effort proposing that transcriptomic cell types, organized as subclass → supertype → type, should serve as the primary reference taxonomy for cortical neurons [Yuste2020,Mao2024,Agmon2024]. The nomenclature effort argued that transcriptomic types provide the most reproducible and scalable basis for cross-laboratory communication, a pos...”
[Gouwens2020a] paper:paper-pm-33186530 “Hierarchical classification of cortical GABAergic interneurons. Five cardinal subclasses (*Pvalb*, *Sst*, *Vip*, *Lamp5*, *Sncg*) are resolved at the top level by scRNA-seq and MERFISH. Each subclass contains multiple supertypes (middle level), which further subdivide into fine transcriptomic types (bottom level, ~100+ in mouse cortex). Cross-modal concordance is strong at the subclass level (transcriptomic subclass...”
[Keijser2024] paper:paper-cae450becc55 “A latent factor analysis of hippocampal interneurons exemplifies this tension: [Harris2018] found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories [Harris2018]. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...”
[Mihaljevic2018] paper:paper-a838b3e9b633 “A latent factor analysis of hippocampal interneurons exemplifies this tension: [Harris2018] found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories [Harris2018]. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...”
[DeFelipe2013] paper:paper-fe4cc5dc7ed7 “A latent factor analysis of hippocampal interneurons exemplifies this tension: [Harris2018] found that a single continuous variable could predict cell-type identity, suggesting that at least some neuron classes may be better described by continuous gradients than discrete categories [Harris2018]. This observation resonates with findings from the isocortex: while discrete subclasses emerge robustly, the boundaries be...”

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