Synthesis: What We Know, What We Think We Know, and What Remains Unknown

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Synthesis: What We Know, What We Think We Know, and What Remains Unknown

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  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference, the basic connectivity rules governing PV perisomatic inhibition 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference, and the role of PV maturation in gating crit...

  • 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference, the basic connectivity rules governing PV perisomatic inhibition 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3, and the role of PV maturation in gating crit...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4 HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6, the basic connectivity rules governing PV perisomatic inhibition 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0, and the role of PV maturation in gating crit...

  • 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1 HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3, the basic connectivity rules governing PV perisomatic inhibition 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7, and the role of PV maturation in gating crit...

  • 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8 HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0, the basic connectivity rules governing PV perisomatic inhibition 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4, and the role of PV maturation in gating crit...

  • 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5 HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7, the basic connectivity rules governing PV perisomatic inhibition 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8 3Citationpaper:paper-aa44cb3f3377HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1, and the role of PV maturation in gating crit...

  • 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2 HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4, the basic connectivity rules governing PV perisomatic inhibition 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8, and the role of PV maturation in gating crit...

  • 4Citationpaper:paper-8f1306666de2HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1, the basic connectivity rules governing PV perisomatic inhibition 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3, the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5, and the role of PV maturation in gating crit...

  • 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6 MODERATE confidence claims include PV entrainment of gamma oscillations (replicated across laboratories but confounded by opsin kinetics; {ref}sec-pv-interneurons), SST-mediated surround suppression (demonstrated in V1 but with area-dependent contradictions; {ref}sec-sst-interneurons), VIP disinhibition as an attentional mechanism (observed across paradigms but with inconsistent effect sizes; {ref}`sec-vip-d...

  • 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7 MODERATE confidence claims include PV entrainment of gamma oscillations (replicated across laboratories but confounded by opsin kinetics; {ref}sec-pv-interneurons), SST-mediated surround suppression (demonstrated in V1 but with area-dependent contradictions; {ref}sec-sst-interneurons), VIP disinhibition as an attentional mechanism (observed across paradigms but with inconsistent effect sizes; {ref}`sec-vip-d...

  • 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8 LOW confidence or CONTESTED claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}sec-cortical-processing) 5Citationpaper:paper-065a0eae69a5HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0, PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}sec-oscillatory-dynamics) 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2, SST-mediated sharpening of orientation tuning (with co...

  • 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3 LOW confidence or CONTESTED claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}sec-cortical-processing) 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5, PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}sec-oscillatory-dynamics) 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7, SST-mediated sharpening of orientation tuning (with co...

  • 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8 LOW confidence or CONTESTED claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}sec-cortical-processing) 6Citationpaper:paper-4c0c7cc4feb7HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0, PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}sec-oscillatory-dynamics) 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2, SST-mediated sharpening of orientation tuning (with co...

  • 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3 LOW confidence or CONTESTED claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}sec-cortical-processing) 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5, PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}sec-oscillatory-dynamics) 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7, SST-mediated sharpening of orientation tuning (with co...

  • 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8 LOW confidence or CONTESTED claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}sec-cortical-processing) 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0, PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}sec-oscillatory-dynamics) 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2, SST-mediated sharpening of orientation tuning (with co...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3 First, the tools that enabled functional dissection also introduced systematic confounds. Cre driver lines that revolutionized cell-type-specific manipulation carry measurable off-target recombination rates — SST-Cre labels 6–10% PV/fast-spiking neurons in some preparations 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5 — and PV-Cre lines co-label both basket and chandelier cells {ref}sec-tools-constraints. The kinetics of channelrho...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6 First, the tools that enabled functional dissection also introduced systematic confounds. Cre driver lines that revolutionized cell-type-specific manipulation carry measurable off-target recombination rates — SST-Cre labels 6–10% PV/fast-spiking neurons in some preparations 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8 — and PV-Cre lines co-label both basket and chandelier cells {ref}sec-tools-constraints. The kinetics of channelrho...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 First, the tools that enabled functional dissection also introduced systematic confounds. Cre driver lines that revolutionized cell-type-specific manipulation carry measurable off-target recombination rates — SST-Cre labels 6–10% PV/fast-spiking neurons in some preparations 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference0 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference1 — and PV-Cre lines co-label both basket and chandelier cells {ref}sec-tools-constraints. The kinetics of channelrho...

  • 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference2 Fourth, the field has relied overwhelmingly on a single species. The mouse provides unparalleled genetic access but introduces species-specific biases. The higher proportion of PV interneurons in mouse versus primate cortex 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference3, the existence of primate-enriched or primate-specific types such as rosehip cells 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference4, and the greater dendritic complexity of human neurons 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference5 all suggest that...

  • 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference6 Fourth, the field has relied overwhelmingly on a single species. The mouse provides unparalleled genetic access but introduces species-specific biases. The higher proportion of PV interneurons in mouse versus primate cortex 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference7, the existence of primate-enriched or primate-specific types such as rosehip cells 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference8, and the greater dendritic complexity of human neurons 2Citationpaper:paper-pm-30382198HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference9 all suggest that...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference00 Fourth, the field has relied overwhelmingly on a single species. The mouse provides unparalleled genetic access but introduces species-specific biases. The higher proportion of PV interneurons in mouse versus primate cortex 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference01, the existence of primate-enriched or primate-specific types such as rosehip cells 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference02, and the greater dendritic complexity of human neurons 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference03 all suggest that...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference04 1. The cardinal-class taxonomy is real and robust. Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference05 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference06 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference07 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference08. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference09 1. The cardinal-class taxonomy is real and robust. Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference10 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference11 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference12 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference13. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference14 1. The cardinal-class taxonomy is real and robust. Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference15 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference16 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference17 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference18. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference19 1. The cardinal-class taxonomy is real and robust. Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference20 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference21 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference22 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference23. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference24 1. The cardinal-class taxonomy is real and robust. Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference25 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference26 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference27 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference28. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference29 1. The cardinal-class taxonomy is real and robust. Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference30 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference31 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference32 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference33. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference34 2. PV basket cells provide fast perisomatic inhibition. The basic connectivity — PV basket cells targeting the soma and proximal dendrites of pyramidal neurons — is among the most thoroughly replicated findings in cortical microcircuit research, confirmed by paired recordings, electron microscopy, and optogenetic mapping across multiple laboratories and species 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference35 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference36.

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference37 2. PV basket cells provide fast perisomatic inhibition. The basic connectivity — PV basket cells targeting the soma and proximal dendrites of pyramidal neurons — is among the most thoroughly replicated findings in cortical microcircuit research, confirmed by paired recordings, electron microscopy, and optogenetic mapping across multiple laboratories and species 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference38 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference39.

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference40 3. The VIP→SST disinhibitory connection exists as a circuit element. Multiple groups have confirmed that VIP interneurons preferentially inhibit SST cells, reducing dendritic inhibition onto pyramidal neurons 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference41 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference42. The existence of this connection is robustly replicated; its computational role and universality across cortical areas are less certain.

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference43 3. The VIP→SST disinhibitory connection exists as a circuit element. Multiple groups have confirmed that VIP interneurons preferentially inhibit SST cells, reducing dendritic inhibition onto pyramidal neurons 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference44 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference45. The existence of this connection is robustly replicated; its computational role and universality across cortical areas are less certain.

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference46 4. PV maturation gates critical-period plasticity in V1. The link between PV interneuron maturation, perineuronal net formation, and the opening of the critical period for ocular dominance plasticity is supported by multiple converging lines of evidence across laboratories 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference47 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference48 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference49. Extension beyond V1 and to non-PV types, however, remains limited {ref}`sec-development-pl...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference50 4. PV maturation gates critical-period plasticity in V1. The link between PV interneuron maturation, perineuronal net formation, and the opening of the critical period for ocular dominance plasticity is supported by multiple converging lines of evidence across laboratories 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference51 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference52 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference53. Extension beyond V1 and to non-PV types, however, remains limited {ref}`sec-development-pl...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference54 4. PV maturation gates critical-period plasticity in V1. The link between PV interneuron maturation, perineuronal net formation, and the opening of the critical period for ocular dominance plasticity is supported by multiple converging lines of evidence across laboratories 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference55 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference56 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference57. Extension beyond V1 and to non-PV types, however, remains limited {ref}`sec-development-pl...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference58 1. Divisive versus subtractive gain control by PV interneurons. The initial reports of apparently contradictory PV-mediated gain operations in visual cortex 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference59 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference60 were not resolved by subsequent work but rather deepened by studies showing that the gain operation depends on stimulus contrast, cortical area, PV activation intensity, and the temporal dynamics of inhibition 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference61 [Holt202...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference62 1. Divisive versus subtractive gain control by PV interneurons. The initial reports of apparently contradictory PV-mediated gain operations in visual cortex 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference63 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference64 were not resolved by subsequent work but rather deepened by studies showing that the gain operation depends on stimulus contrast, cortical area, PV activation intensity, and the temporal dynamics of inhibition 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference65 [Holt202...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference66 1. Divisive versus subtractive gain control by PV interneurons. The initial reports of apparently contradictory PV-mediated gain operations in visual cortex 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference67 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference68 were not resolved by subsequent work but rather deepened by studies showing that the gain operation depends on stimulus contrast, cortical area, PV activation intensity, and the temporal dynamics of inhibition 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference69 [Holt202...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference70 1. Divisive versus subtractive gain control by PV interneurons. The initial reports of apparently contradictory PV-mediated gain operations in visual cortex 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference71 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference72 were not resolved by subsequent work but rather deepened by studies showing that the gain operation depends on stimulus contrast, cortical area, PV activation intensity, and the temporal dynamics of inhibition 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference73 [Holt202...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference74 2. PV exclusivity in gamma generation. While PV interneurons can entrain gamma oscillations, the claim that they are the sole or necessary generators has been contested by demonstrations that SST manipulation also modulates gamma power, that non-PV interneurons sustain gamma-band activity, and that the original optogenetic evidence may be confounded by ChR2 frequency-dependent responses 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference75 [Antonoudiou20...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference76 2. PV exclusivity in gamma generation. While PV interneurons can entrain gamma oscillations, the claim that they are the sole or necessary generators has been contested by demonstrations that SST manipulation also modulates gamma power, that non-PV interneurons sustain gamma-band activity, and that the original optogenetic evidence may be confounded by ChR2 frequency-dependent responses 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference77 [Antonoudiou20...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference78 2. PV exclusivity in gamma generation. While PV interneurons can entrain gamma oscillations, the claim that they are the sole or necessary generators has been contested by demonstrations that SST manipulation also modulates gamma power, that non-PV interneurons sustain gamma-band activity, and that the original optogenetic evidence may be confounded by ChR2 frequency-dependent responses 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference79 [Antonoudiou20...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference80 3. SST-mediated orientation tuning sharpening. The initial report that SST inhibition sharpens orientation tuning 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference81 has been followed by studies finding no effect or even broadening under different conditions, with the outcome depending on whether the preparation is anesthetized or awake, the stimulus set used, and the specific SST subpopulation engaged {ref}sec-sst-interneurons.

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference82 4. Chandelier cell polarity at the axon initial segment. Whether chandelier cell synapses onto the axon initial segment are depolarizing (potentially excitatory) or hyperpolarizing (classically inhibitory) remains unresolved, with evidence depending on the local chloride gradient and the developmental state of the recorded neuron 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference83 {ref}sec-beyond-cardinal.

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference84 Most functional attributions generalize across cortical areas. The vast majority of cell-type-specific perturbation studies have been conducted in primary visual cortex or somatosensory barrel cortex. Whether PV cells perform the same gain control operations in prefrontal cortex, whether SST cells mediate surround suppression in auditory cortex, and whether VIP disinhibition operates similarly in motor cortex are...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference85 Most functional attributions generalize across cortical areas. The vast majority of cell-type-specific perturbation studies have been conducted in primary visual cortex or somatosensory barrel cortex. Whether PV cells perform the same gain control operations in prefrontal cortex, whether SST cells mediate surround suppression in auditory cortex, and whether VIP disinhibition operates similarly in motor cortex are...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference86 Developmental maturation timecourses are known for non-PV types. While PV interneuron maturation has been extensively studied in the context of critical-period plasticity, the developmental trajectories of SST, VIP, Lamp5, and chandelier cell populations remain poorly characterized 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference87 {ref}sec-development-plasticity. This gap is particularly problematic for disease models where inhibitory circuit dysfu...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference88 Single-cell-type perturbation isolates the computation of that cell type. Optogenetic activation or silencing of one population necessarily changes the activity of all connected populations within milliseconds. The measured change in network output reflects the perturbation cascading through an interconnected circuit, not the isolated contribution of the targeted type. This interpretive limitation is widely acknow...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference89 Mouse findings translate to human cortex. The field routinely extrapolates from mouse to human in clinical discussions of schizophrenia (PV deficits), autism (excitation/inhibition imbalance), and epilepsy (interneuron dysfunction). Yet the substantial differences in inhibitory neuron proportions, subtype composition, and dendritic architecture between mouse and human cortex {ref}sec-cross-species make such extr...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference90 Mouse findings translate to human cortex. The field routinely extrapolates from mouse to human in clinical discussions of schizophrenia (PV deficits), autism (excitation/inhibition imbalance), and epilepsy (interneuron dysfunction). Yet the substantial differences in inhibitory neuron proportions, subtype composition, and dendritic architecture between mouse and human cortex {ref}sec-cross-species make such extr...

  • 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference91 1. Is the cardinal-class framework the right level of abstraction for understanding inhibitory computation? The five-class scheme is molecularly robust, but {ref}sec-beyond-cardinal documents dozens of transcriptomic subtypes within each class whose functional significance is unknown. If Martinotti and non-Martinotti SST cells compute fundamentally different operations 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference92 1Citationpaper:paper-4dfe44516146HIGH confidence claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...content/13_synthesis.md:line 18Open reference93, then the "SST int...

  • ... 17 additional anchors in refs_json

References

  1. [Yao2021] paper:paper-4dfe44516146 “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  2. [Tasic2018] paper:paper-pm-30382198 “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  3. [DeFelipe1986] paper:paper-aa44cb3f3377 “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  4. [Donato2023] paper:paper-8f1306666de2 “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  5. [Pi2013] paper:paper-065a0eae69a5 “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  6. [Apicella2022] paper:paper-4c0c7cc4feb7 “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  7. [Hensch1998] paper:paper-4aca13fdbcb5 “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  8. [Beurdeley2012] paper:paper-3d4b87eb92da “**HIGH confidence** claims include the existence and molecular coherence of cardinal inhibitory classes [Yao2021] [Tasic2018], the basic connectivity rules governing PV perisomatic inhibition [DeFelipe1986] [Donato2023], the VIP→SST disinhibitory motif as a circuit element that exists (though not necessarily as a universal computational primitive) [Pi2013] [Apicella2022], and the role of PV maturation in gating crit...”
  9. [Bakken2021] paper:paper-pm-34616062 “**MODERATE confidence** claims include PV entrainment of gamma oscillations (replicated across laboratories but confounded by opsin kinetics; {ref}`sec-pv-interneurons`), SST-mediated surround suppression (demonstrated in V1 but with area-dependent contradictions; {ref}`sec-sst-interneurons`), VIP disinhibition as an attentional mechanism (observed across paradigms but with inconsistent effect sizes; {ref}`sec-vip-d...”
  10. [Lee2023a] paper:paper-37824669 “**MODERATE confidence** claims include PV entrainment of gamma oscillations (replicated across laboratories but confounded by opsin kinetics; {ref}`sec-pv-interneurons`), SST-mediated surround suppression (demonstrated in V1 but with area-dependent contradictions; {ref}`sec-sst-interneurons`), VIP disinhibition as an attentional mechanism (observed across paradigms but with inconsistent effect sizes; {ref}`sec-vip-d...”
  11. [Seybold2015] paper:paper-63edd004db85 “**LOW confidence or CONTESTED** claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}`sec-cortical-processing`) [Seybold2015] [Phillips2016], PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}`sec-oscillatory-dynamics`) [Veit2017] [Antonoudiou2020], SST-mediated sharpening of orientation tuning (with co...”
  12. [Phillips2016] paper:paper-bf203bb1496d “**LOW confidence or CONTESTED** claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}`sec-cortical-processing`) [Seybold2015] [Phillips2016], PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}`sec-oscillatory-dynamics`) [Veit2017] [Antonoudiou2020], SST-mediated sharpening of orientation tuning (with co...”
  13. [Veit2017] paper:paper-676bfe401c07 “**LOW confidence or CONTESTED** claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}`sec-cortical-processing`) [Seybold2015] [Phillips2016], PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}`sec-oscillatory-dynamics`) [Veit2017] [Antonoudiou2020], SST-mediated sharpening of orientation tuning (with co...”
  14. [Antonoudiou2020] paper:paper-4d3be038bd01 “**LOW confidence or CONTESTED** claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}`sec-cortical-processing`) [Seybold2015] [Phillips2016], PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}`sec-oscillatory-dynamics`) [Veit2017] [Antonoudiou2020], SST-mediated sharpening of orientation tuning (with co...”
  15. [Woodruff2009] paper:paper-c803cdbd5cbd “**LOW confidence or CONTESTED** claims include PV-mediated divisive gain control (with ongoing disagreement about subtractive versus divisive mechanisms; {ref}`sec-cortical-processing`) [Seybold2015] [Phillips2016], PV as the exclusive generator of cortical gamma (challenged by multiple laboratories; {ref}`sec-oscillatory-dynamics`) [Veit2017] [Antonoudiou2020], SST-mediated sharpening of orientation tuning (with co...”
  16. [Taniguchi2013] paper:paper-19c6b2a4a9fa “First, *the tools that enabled functional dissection also introduced systematic confounds*. Cre driver lines that revolutionized cell-type-specific manipulation carry measurable off-target recombination rates — SST-Cre labels 6–10% PV/fast-spiking neurons in some preparations [Taniguchi2013] [Hu2013] — and PV-Cre lines co-label both basket and chandelier cells {ref}`sec-tools-constraints`. The kinetics of channelrho...”
  17. [Hu2013] paper:paper-be41a3526e45 “First, *the tools that enabled functional dissection also introduced systematic confounds*. Cre driver lines that revolutionized cell-type-specific manipulation carry measurable off-target recombination rates — SST-Cre labels 6–10% PV/fast-spiking neurons in some preparations [Taniguchi2013] [Hu2013] — and PV-Cre lines co-label both basket and chandelier cells {ref}`sec-tools-constraints`. The kinetics of channelrho...”
  18. [Cardin2009] paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d “First, *the tools that enabled functional dissection also introduced systematic confounds*. Cre driver lines that revolutionized cell-type-specific manipulation carry measurable off-target recombination rates — SST-Cre labels 6–10% PV/fast-spiking neurons in some preparations [Taniguchi2013] [Hu2013] — and PV-Cre lines co-label both basket and chandelier cells {ref}`sec-tools-constraints`. The kinetics of channelrho...”
  19. [Krimer2005] paper:paper-c5fb827111ed “Fourth, *the field has relied overwhelmingly on a single species*. The mouse provides unparalleled genetic access but introduces species-specific biases. The higher proportion of PV interneurons in mouse versus primate cortex [Krimer2005], the existence of primate-enriched or primate-specific types such as rosehip cells [Boldog2018], and the greater dendritic complexity of human neurons [Juarez2022] all suggest that...”
  20. [Boldog2018] paper:paper-pm-30150662 “Fourth, *the field has relied overwhelmingly on a single species*. The mouse provides unparalleled genetic access but introduces species-specific biases. The higher proportion of PV interneurons in mouse versus primate cortex [Krimer2005], the existence of primate-enriched or primate-specific types such as rosehip cells [Boldog2018], and the greater dendritic complexity of human neurons [Juarez2022] all suggest that...”
  21. [Juarez2022] paper:paper-77732da7b791 “Fourth, *the field has relied overwhelmingly on a single species*. The mouse provides unparalleled genetic access but introduces species-specific biases. The higher proportion of PV interneurons in mouse versus primate cortex [Krimer2005], the existence of primate-enriched or primate-specific types such as rosehip cells [Boldog2018], and the greater dendritic complexity of human neurons [Juarez2022] all suggest that...”
  22. [Gouwens2020a] paper:paper-pm-33186530 “1. **The cardinal-class taxonomy is real and robust.** Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology [Yao2021] [Tasic2018] [Gouwens2020a] [Scala2021]. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...”
  23. [Scala2021] paper:paper-be132b319290 “1. **The cardinal-class taxonomy is real and robust.** Multiple independent scRNA-seq studies converge on PV, SST, VIP, Lamp5, and Sncg as major inhibitory subclasses, with cross-modal concordance extending to electrophysiology and morphology [Yao2021] [Tasic2018] [Gouwens2020a] [Scala2021]. This classification is conserved across mouse, macaque, marmoset, and human cortex at the subclass level, though proportions a...”
  24. [Chattopadhyaya2007] paper:paper-61e336542c28 “4. **PV maturation gates critical-period plasticity in V1.** The link between PV interneuron maturation, perineuronal net formation, and the opening of the critical period for ocular dominance plasticity is supported by multiple converging lines of evidence across laboratories [Hensch1998] [Beurdeley2012] [Chattopadhyaya2007]. Extension beyond V1 and to non-PV types, however, remains limited {ref}`sec-development-pl...”
  25. [Lee2010a] paper:paper-9cfdde391cfd “1. **Divisive versus subtractive gain control by PV interneurons.** The initial reports of apparently contradictory PV-mediated gain operations in visual cortex [Lee2010a] [Bigelow2019] were not resolved by subsequent work but rather deepened by studies showing that the gain operation depends on stimulus contrast, cortical area, PV activation intensity, and the temporal dynamics of inhibition [Phillips2016] [Holt202...”
  26. [Bigelow2019] paper:paper-a8e4661056ad “1. **Divisive versus subtractive gain control by PV interneurons.** The initial reports of apparently contradictory PV-mediated gain operations in visual cortex [Lee2010a] [Bigelow2019] were not resolved by subsequent work but rather deepened by studies showing that the gain operation depends on stimulus contrast, cortical area, PV activation intensity, and the temporal dynamics of inhibition [Phillips2016] [Holt202...”
  27. [Holt2023] paper:paper-21a697680a63 “1. **Divisive versus subtractive gain control by PV interneurons.** The initial reports of apparently contradictory PV-mediated gain operations in visual cortex [Lee2010a] [Bigelow2019] were not resolved by subsequent work but rather deepened by studies showing that the gain operation depends on stimulus contrast, cortical area, PV activation intensity, and the temporal dynamics of inhibition [Phillips2016] [Holt202...”
  28. [Onorato2025] paper:paper-19f771cb3f48 “2. **PV exclusivity in gamma generation.** While PV interneurons can entrain gamma oscillations, the claim that they are the sole or necessary generators has been contested by demonstrations that SST manipulation also modulates gamma power, that non-PV interneurons sustain gamma-band activity, and that the original optogenetic evidence may be confounded by ChR2 frequency-dependent responses [Veit2017] [Antonoudiou20...”
  29. [Naka2019] paper:paper-7881c9e4267e “3. **SST-mediated orientation tuning sharpening.** The initial report that SST inhibition sharpens orientation tuning [Naka2019] has been followed by studies finding no effect or even broadening under different conditions, with the outcome depending on whether the preparation is anesthetized or awake, the stimulus set used, and the specific SST subpopulation engaged {ref}`sec-sst-interneurons`.”
  30. [Preuss2026] paper:paper-737e539c1091 “*Most functional attributions generalize across cortical areas.* The vast majority of cell-type-specific perturbation studies have been conducted in primary visual cortex or somatosensory barrel cortex. Whether PV cells perform the same gain control operations in prefrontal cortex, whether SST cells mediate surround suppression in auditory cortex, and whether VIP disinhibition operates similarly in motor cortex are...”
  31. [Dienel2025] paper:paper-db4f0d3ef882 “*Developmental maturation timecourses are known for non-PV types.* While PV interneuron maturation has been extensively studied in the context of critical-period plasticity, the developmental trajectories of SST, VIP, Lamp5, and chandelier cell populations remain poorly characterized [Dienel2025] {ref}`sec-development-plasticity`. This gap is particularly problematic for disease models where inhibitory circuit dysfu...”
  32. [McGarry2010] paper:paper-bf344c0a6a03 “1. *Is the cardinal-class framework the right level of abstraction for understanding inhibitory computation?* The five-class scheme is molecularly robust, but {ref}`sec-beyond-cardinal` documents dozens of transcriptomic subtypes within each class whose functional significance is unknown. If Martinotti and non-Martinotti SST cells compute fundamentally different operations [Naka2019] [McGarry2010], then the "SST int...”

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