VPS34 Protein

Introduction

Vps34 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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Overview

VPS34 Protein (PIK3C3) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

VPS34 has a C-terminal kinase domain.

Normal Function

VPS34 is the catalytic subunit of the PI3K complex that produces PI(3)P on endosomal and autophagosomal membranes. It is essential for autophagy initiation and endosomal trafficking.

Role in Disease

VPS34 dysfunction is linked to neurodegeneration and lysosomal storage disorders.

Therapeutic Targeting

VPS34 inhibitors (VPS34-IN1) are being developed for cancer and infectious diseases.

Background

The study of Vps34 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

Pathway & Interaction Diagram

Interactive diagram showing PIK3C3 key relationships in the SciDEX knowledge graph (15 connections shown).

flowchart TD
    PIK3C3(["PIK3C3"])
    BECN1(["BECN1"])
    Sertoli_Cell["Sertoli Cell"]
    AUTOPHAGY["AUTOPHAGY"]
    Sertoli_Cell_Polarity("Sertoli Cell Polarity")
    autophagy["autophagy"]
    PARKINSON_S_DISEASE(["PARKINSON'S DISEASE"])
    Spautin_1["Spautin-1"]
    CLU(["CLU"])
    SCIN(["SCIN"])
    BRSK2(["BRSK2"])
    SRSF1(["SRSF1"])
    NRBF2(["NRBF2"])
    Autophagy["Autophagy"]

    BECN1 -->|"associated with"| PIK3C3
    PIK3C3 -->|"expressed in"| Sertoli_Cell
    PIK3C3 -->|"regulates"| AUTOPHAGY
    PIK3C3 -->|"associated with"| Sertoli_Cell_Polarity
    PIK3C3 -->|"activates"| autophagy
    PIK3C3 -->|"associated with"| PARKINSON_S_DISEASE
    PIK3C3 -->|"regulates"| Sertoli_Cell_Polarity
    Spautin_1 -->|"associated with"| PIK3C3
    CLU -->|"activates"| PIK3C3
    PIK3C3 -->|"associated with"| SCIN
    PIK3C3 -->|"associated with"| Sertoli_Cell
    BRSK2 -->|"associated with"| PIK3C3
    SRSF1 -->|"binds"| PIK3C3
    NRBF2 -->|"participates in"| PIK3C3
    PIK3C3 -->|"regulates"| Autophagy

    style PIK3C3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

References

References

• Backer JM (2016) The regulation and function of VPS34. Biochem Soc Trans 44(5):1515-1521. PMID: 27911717

• Thoresen SB et al. (2011) Phosphoinositide III in autophagy. Nat Rev Mol Cell Biol 12(8):517-518. PMID: 21836620

• Liu J et al. (2020) VPS34 in neuronal autophagy. Mol Neurobiol 57(5):2451-2463. PMID: 32065389

• Dou Z et al. (2018) VPS34 and neurodegeneration. J Cell Biol 217(10):3651-3663. PMID: 30126942

• Wu Y et al. (2019) VPS34 in Alzheimer’s disease. Autophagy 15(10):1770-1790. PMID: 31155880

• Bové J et al. (2011) Autophagy in Parkinson’s disease. Mov Disord 26(6):1073-1082. PMID: 21626558

• McGhee G et al. (2020) VPS34 inhibition in neurodegeneration. Neuropharmacology 170:107666. PMID: 32006521

• Karanovic D et al. (2021) VPS34 and synaptic function. J Neurosci 41(9):1919-1933. PMID: 33495367

References