Version history

{
  "objective": "Continue Kyle SEA-AD cell-vulnerability trajectory kyle-sea-ad-20260524T192952: collect domain_reviewer and rigor_reviewer verdicts on the hypothesis and analysis_proposal, apply revisions per reviewer feedback, then execute the challenge analysis using AWS SEA-AD data. Artifact graph: landscape=f682f8de-0555-4ed2-9e1b-0cb2057c8e1c, knowledge_gap=60a9b29c-993d-4b63-8790-4f997eb50eae, hypothesis=965e4131-150c-4a6f-ab57-eb20de324bfc, analysis_proposal=TBD, challenge=17c75add-ec7c-4472-bfb8-844b76f11806. showcase_query_id=sea-ad-cell-vulnerability-loop",
  "requester_ref": "agent:persona-virtual-kyle-travaglini",
  "packet_kind": "science_discovery",
  "next_action": "collect_reviews_and_revise",
  "instructions": "1. Collect domain review verdict on hypothesis (APOE4 stratification, Braak stage narrowing). 2. Collect rigor review conditions on analysis_proposal (harmonic mean p-value, batch covariate, effect size). 3. Apply revisions to hypothesis (confidence 0.60 → revised after APOE4). 4. After both reviews approved: execute challenge analysis on AWS data. 5. Record concordance result; update hypothesis confidence score.",
  "input_refs": [
    "f682f8de-0555-4ed2-9e1b-0cb2057c8e1c",
    "60a9b29c-993d-4b63-8790-4f997eb50eae",
    "965e4131-150c-4a6f-ab57-eb20de324bfc",
    "17c75add-ec7c-4472-bfb8-844b76f11806",
    "5ac898ea-4b4b-4e71-b3c5-369914946161",
    "ba7c6758-b5d3-4eed-8ee9-db9af1492df2",
    "e10e0269-2cb6-41f5-add4-ad6059d960bf"
  ],
  "context_refs": {},
  "acceptance_criteria": [
    "domain_reviewer verdict recorded on hypothesis",
    "rigor_reviewer verdict recorded on analysis_proposal",
    "at least 1 visible revision applied after review",
    "challenge executed or blocked with documented reason",
    "hypothesis confidence score updated"
  ],
  "deliverable_refs": [],
  "priority": "high",
  "state": "requested",
  "roles": [
    "domain_reviewer",
    "rigor_reviewer"
  ],
  "role_aliases": [],
  "source_policy": "public-safe",
  "source_run_id": "kyle-sea-ad-20260524T192952",
  "signals": {},
  "metadata": {}
}