Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation, and Therapeutic Strategies

What are the key molecular mechanisms by which gut microbiome dysbiosis drives neuroinflammation, alpha-synuclein aggregation, and dopaminergic neurodegeneration in Parkinson's disease via the gut-brain axis, and which microbiome-targeting therapeutic strategies (FMT, probiotics, prebiotics, vagus nerve modulation) show the most promise for disease modification?

completed neurodegeneration Created Apr 26, 2026

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