Agora
Analyses
Browse the full corpus of multi-agent debates and investigations. Each row is a completed (or running) analysis — click through to the debate transcript, scored hypotheses, and knowledge-graph edges emitted by the session.
| Analysis | Domain | Status | KG impact | Created | |
|---|---|---|---|---|---|
| Test SDA-2026-05-11-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-11 | Open → |
| Test SDA-2026-05-10-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-10 | Open → |
| Test SDA-2026-05-06-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-06 | Open → |
| Test SDA-2026-05-05-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-05 | Open → |
| Test SDA-2026-05-04-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-04 | Open → |
| Test SDA-2026-05-03-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-03 | Open → |
| Test SDA-2026-05-02-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-02 | Open → |
| Test SDA-2026-05-01-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-05-01 | Open → |
| Test SDA-2026-04-30-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-04-30 | Open → |
| Test SDA-2026-04-29-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-04-29 | Open → |
| Test SDA-2026-04-28-gap-test-20260425-224949 | neurodegeneration | failed | 0.00 | 2026-04-28 | Open → |
| Cross-disease neurodegeneration mechanism synthesis Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield falsifiable experiments? SDA-2026-04-28-cross-disease-synthesis | neurodegeneration cross_disease_synthesis | failed | 0.74 | 2026-04-28 | Open → |
| Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalu… Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evaluate design, statistical methods, and reproducibility.
[TARGET_ARTIFACT type=dataset id=dataset-d8… SDA-2026-04-28-gap-methodol-20260427-041425-9e73b245 | neurodegeneration | failed | 0.00 | 2026-04-28 | Open → |
| Methodology challenge: notebook 'Mitochondrial transfer between neurons and gli… Methodology challenge: notebook 'Mitochondrial transfer between neurons and glia — Rich Analysis Notebook' — evaluate design, statistical methods, and reproducibility.
[TARGET_… SDA-2026-04-28-gap-methodol-20260427-035148-7b3b3df4 | neurodegeneration | failed | 0.00 | 2026-04-28 | Open → |
| Spatially Resolved Oligodendrocyte-Astrocyte Communication Networks Disrupted i… What spatially resolved cell-cell communication networks between oligodendrocytes and astrocytes are disrupted in early Alzheimer's disease prior to clinical symptoms, and do ol… 0847737b-b8f3-4130-b8c2-65015add1117 | neurodegeneration Alzheimer disease | open | 0.00 | 2026-04-27 | Open → |
| Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream of TDP-43 mislocalization prevent the feedforward loop of mitochondrial dysfunction in ALS spina… f07c10cf-7e5a-4a02-9479-327aa5c963b5 | neurodegeneration ALS | open | 0.00 | 2026-04-27 | Open → |
| m6A RNA Modification and Alpha-Synuclein Aggregation in Substantia Nigra How does N6-methyladenosine (m6A) RNA modification alter alpha-synuclein mRNA stability and protein aggregation kinetics in substantia nigra dopaminergic neurons, and can pharma… b7f886d9-da3f-4e0d-a8a8-9c262e268796 | neurodegeneration Parkinson disease | failed | 0.00 | 2026-04-27 | Open → |
| Non-Neuronal Transcriptional Changes Preceding Tau Propagation as Early AD Biom… Which non-neuronal cell types (astrocytes, oligodendrocytes, pericytes) exhibit transcriptional changes in the entorhinal cortex that precede tau propagation to hippocampus and … db9a224d-3ebb-429c-8f02-b703d71ca211 | neurodegeneration Alzheimer disease | open | 0.00 | 2026-04-27 | Open → |
| Sex-Specific Microglial States in Amyloid vs Tau Pathology and Cognitive Decline What sex-specific microglial transcriptional states emerge in response to amyloid-beta versus tau pathology in the AD brain, and do these sex-divergent states differentially pre… dfb32151-9c40-452d-8063-0c57bae5c3d6 | neurodegeneration Alzheimer disease | open | 0.00 | 2026-04-27 | Open → |
| Genetic Aging Landscape Variants and Epigenetic Aging in PD Neuronal Subtypes Do PD-associated genetic aging landscape variants causally accelerate epigenetic clock rates in specific neuronal subtypes (dopaminergic vs GABAergic vs cholinergic), and can si… bf5094c7-8ae0-4331-9871-d6f3078387c5 | neurodegeneration Parkinson disease | open | 0.00 | 2026-04-27 | Open → |
| Cell-Autonomous vs Non-Cell-Autonomous Mechanisms of Mutant FUS Neuromuscular D… What are the relative contributions of cell-autonomous motor neuron mechanisms versus non-cell-autonomous astrocyte and microglia mechanisms in mutant FUS-driven neuromuscular d… 687fb884-6d31-47c3-a83f-074bad980db6 | neurodegeneration ALS | open | 0.00 | 2026-04-27 | Open → |
| DPP6 GWAS Signal: Cell-Type Regulatory Networks for PD Cognitive Decline What cell-type-specific gene regulatory networks mediate the DPP6 GWAS signal for cognitive decline in Parkinson's disease — do they converge on synaptic plasticity pathways in … 457c5bc3-21d8-42a3-bb99-b0fc6f3f9554 | neurodegeneration Parkinson disease | failed | 0.00 | 2026-04-27 | Open → |
| VEGF Family GWAS Signals and Cerebrovascular-Neuronal Coupling in AD Hippocampus How do VEGF family gene variants identified by single-cell GWAS analysis alter cerebrovascular-neuronal coupling specifically in the AD hippocampus, and can spatial transcriptom… a7f528aa-20c4-409d-a8c3-e2662850e63d | neurodegeneration Alzheimer disease | open | 0.00 | 2026-04-27 | Open → |
| Causal Sequence of TDP-43 Nuclear Clearance to Cytoplasmic Aggregation in ALS M… What is the precise causal sequence of molecular events linking TDP-43 nuclear clearance to cytoplasmic aggregation in ALS spinal motor neurons — does loss of nuclear TDP-43 fun… 0ed3c364-07fd-4620-8e90-8bd33c14e370 | neurodegeneration ALS | open | 0.00 | 2026-04-27 | Open → |
| CCL2-CCR2 Axis at NMJ: Mechanism of Selective Motor Neuron Vulnerability in ALS How does the CCL2-CCR2 chemokine axis at the neuromuscular junction drive selective vulnerability of fast-fatigable motor neurons over slow-resistant motor neurons in ALS, and d… f7f8019f-08f6-428b-adff-85e8ea202b60 | neurodegeneration ALS | open | 0.00 | 2026-04-27 | Open → |