VEGF Family GWAS Signals and Cerebrovascular-Neuronal Coupling in AD Hippocampus

How do VEGF family gene variants identified by single-cell GWAS analysis alter cerebrovascular-neuronal coupling specifically in the AD hippocampus, and can spatial transcriptomics resolve whether VEGF-driven vascular dysfunction precedes or follows amyloid deposition in vulnerable hippocampal subfields?

open neurodegeneration · Alzheimer disease Created Apr 27, 2026

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