Non-Neuronal Transcriptional Changes Preceding Tau Propagation as Early AD Biomarkers

Which non-neuronal cell types (astrocytes, oligodendrocytes, pericytes) exhibit transcriptional changes in the entorhinal cortex that precede tau propagation to hippocampus and neocortex in AD, and can single-nucleus RNA-seq from cognitively normal APOE ε4 carriers identify these as pre-clinical biomarkers?

open neurodegeneration · Alzheimer disease Created Apr 27, 2026

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