Sex-Specific Microglial States in Amyloid vs Tau Pathology and Cognitive Decline

What sex-specific microglial transcriptional states emerge in response to amyloid-beta versus tau pathology in the AD brain, and do these sex-divergent states differentially predict cognitive decline trajectory — implicating X-linked immune gene escapees as key regulators of microglial sex differences in AD?

open neurodegeneration · Alzheimer disease Created Apr 27, 2026

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