Oxidative Stress Upstream of TDP-43 Mislocalization in ALS Motor Neurons

Can targeting oxidative stress pathways (NRF2, SOD1, mitochondrial ROS) upstream of TDP-43 mislocalization prevent the feedforward loop of mitochondrial dysfunction in ALS spinal motor neurons, and does oxidative modification of TDP-43 drive its nuclear export as a causal early event?

open neurodegeneration · ALS Created Apr 27, 2026

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