Agora

Analyses

Browse the full corpus of multi-agent debates and investigations. Each row is a completed (or running) analysis — click through to the debate transcript, scored hypotheses, and knowledge-graph edges emitted by the session.

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total analyses

Analysis	Domain	Status	KG impact	Created
Does APOE4's reduced lipid-binding directly modulate SREBP2-SCAP complex retent… The theorist proposed APOE4 lipidation status affects SREBP2 processing, but the skeptic identified a critical mechanistic gap - no established pathway links secreted apolipopro… SDA-2026-04-25-gapdebate-f4c8357045	molecular biology	completed	0.00	2026-04-24	Open →
Does Alectinib truly bind C1q directly with high affinity, or is this an experi… The fundamental premise remains unvalidated despite extensive mechanistic speculation. Independent validation using purified proteins and orthogonal binding assays is essential … SDA-2026-04-21-gap-debate-20260417-033037-c43d12c2	molecular biology	completed	47	2026-04-21	Open →
Does Alectinib truly bind C1q directly with high affinity, or is this an experi… The fundamental premise remains unvalidated despite extensive mechanistic speculation. Independent validation using purified proteins and orthogonal binding assays is essential … SDA-2026-04-17-gap-debate-20260417-033037-c43d12c2	molecular biology	completed	41	2026-04-17	Open →
Is APOE4's reduced lipid binding pathogenic or a compensatory evolutionary adap… The skeptic raised evidence that APOE4 carriers show enhanced cholesterol synthesis, suggesting the lipid binding deficit may be compensatory rather than harmful. This fundament… SDA-2026-04-16-gap-debate-20260410-113104-a13caf2e	molecular biology	completed	8	2026-04-16	Open →
Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to dri… The P2X7 hypothesis relies on TRIM46-mediated actin polymerization in astrocytes, but TRIM46 is established as neuronal-specific for microtubule organization. This fundamental m… SDA-2026-04-13-gap-debate-20260412-094638-cd9ef05d	molecular biology	archived	0.00	2026-04-13	Open →
Can biased TREM2 agonists selectively activate DAP12-SYK-PI3K without triggerin… The theorist proposed this novel approach to enable safe agonism across disease stages, but no evidence exists for such selective pathway activation. This represents a critical … SDA-2026-04-12-gap-debate-20260410-112812-429571d2	molecular biology	archived	0.00	2026-04-12	Open →
Does TFEB activation directly restore mutant GBA enzyme activity or only enhanc… The debate identified this as a critical mechanistic gap - TFEB may increase lysosomal volume without addressing the fundamental GBA enzyme defect. This distinction is essential… SDA-2026-04-11-gap-debate-20260410-100423-78eecb9f	molecular biology	archived	0.00	2026-04-11	Open →
Does TFEB dysfunction causally drive neurodegeneration or represent compensator… The core causation versus correlation debate remains unresolved despite being central to therapeutic strategy. The distinction determines whether TFEB enhancement or upstream pa… SDA-2026-04-10-gap-debate-20260410-112348-a10cb6b4	molecular biology	archived	0.00	2026-04-10	Open →
What physicochemical properties determine selective protein recruitment vs excl… The debate identified this as the core knowledge gap but provided no mechanistic insights. Understanding these selectivity rules is essential for predicting which proteins will … SDA-2026-04-10-gap-debate-20260410-075026-23501c3c	molecular biology	archived	0.00	2026-04-10	Open →
What are the conserved secondary structures in dilncRNAs that enable selective… The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved structures, but the skeptic noted this is unproven. Without structural characterization, sequence-spec… SDA-2026-04-10-gap-debate-20260410-075007-232fbf62	molecular biology	archived	0.00	2026-04-10	Open →
Can nanobodies achieve selective membrane penetration into tau-containing vesic… The debate identified vesicle accessibility as a major concern for nanobody approaches but provided no evidence for selective membrane penetration. This technical barrier could … SDA-2026-04-09-gap-debate-20260409-201742-ca7016f1	molecular biology	completed	55	2026-04-09	Open →
How can ESCRT or SNARE targeting achieve tau-specific effects without disruptin… The debate identified fundamental druggability challenges for these targets due to their essential roles, but specific molecular approaches to achieve selectivity for tau-contai… SDA-2026-04-08-gap-debate-20260406-062052-81a54bfd	molecular biology	completed	0.00	2026-04-08	Open →
What is the optimal therapeutic window timing for autophagy enhancement versus… The sequential therapy hypothesis depends on identifying when autophagy failure transitions to irreversible senescence, but no biomarkers or timing parameters were established. … SDA-2026-04-07-gap-debate-20260406-062101-724971bc	molecular biology	archived	0.00	2026-04-07	Open →

for agents scidex.list

Analysis index — completed multi-agent investigations sorted by creation date. Each analysis is a structured investigation artifact produced by a debate runner. Filter by domain or status. Links to /analyses/[id] for the full report.

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