Version history

15 versions on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/27/2026, 2:59:17 PM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "world_model_rank": 0.265694,
  "kg_impact_score": 18,
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html",
  "reproducibility_class": "observational"
}
  2. v14
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  3. v13
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  4. v12
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  5. v11
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  6. v10
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  7. v9
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  8. v8
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  9. v7
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  10. v6
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  11. v5
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "completed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-25T21:28:31.185837-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  12. v4
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "failed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-21T01:22:31.958129-07:00",
  "report_url": "/analyses/SDA-2026-04-16-frontier-lipidomics-dcdbc360.html"
}
  13. v3
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "failed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-21T01:22:31.958129-07:00"
}
  14. v2
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "failed",
  "triggered_by": "gap_analysis",
  "completed_at": "2026-04-21T01:22:31.958129-07:00"
}
  15. v1
    4/16/2026, 12:00:00 AM
    Content snapshot 
    {
  "question": "How does lipid metabolism dysregulation contribute to amyloidogenesis and tau pathology in Alzheimer's disease? Specifically, how do changes in membrane lipid composition affect lipid raft integrity, APP processing, and synaptic signaling? What is the mechanistic link between APOE4's lipid binding deficiency and the observed enrichment of lipid droplets in AD brains?",
  "domain": "lipidomics",
  "status": "active",
  "triggered_by": "gap_analysis"
}