Version history

5 versions on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/27/2026, 6:28:15 PM
    Content snapshot 
    {
  "question": "What distinguishes seed-competent tau species from non-pathogenic tau during trans-synaptic transfer?",
  "domain": "neurodegeneration",
  "status": "completed",
  "triggered_by": "codex:aa724961",
  "gap_id": "gap-debate-20260412-094623-bb7e1c4f",
  "metadata": {
    "source": "scripts/generate_3_analyses.py",
    "dissent": [
      "The skeptic argued that many observed tau strains may be assay artifacts unless validated across PMCA, RT-QuIC, FRET biosensor, and in vivo spread systems.",
      "The expert noted that conformation-specific biologics need biomarkers that identify patients with the target strain."
    ],
    "task_id": "aa724961-6a40-495d-9c89-26dadaeda2bd",
    "consensus": [
      "Seed competence must be defined functionally by templating kinetics, not only by aggregate size or uptake.",
      "Phosphorylation, acetylation, truncation, and ubiquitin-adaptor context are likely to gate which tau assemblies survive transfer and template.",
      "Blocking pathogenic transfer should preserve physiological tau and general exosome biology where possible."
    ],
    "debate_summary": "The debate separated tau movement from tau templating. The strongest hypotheses focus on conformer state, post-translational modification barcodes, and vesicle/synapse context as jointly necessary for seed competence. The synthesis recommends paired structural and functional seeding assays rather than morphology-only tau aggregate comparisons.",
    "world_model_ranking": {
      "formula": "0.30*kg_impact + 0.25*hyp_quality + 0.20*debate_depth + 0.15*gap_addressed + 0.10*research_depth",
      "task_id": "ce3182a7-f33b-44b6-9dd8-ef784cf9e231",
      "weights": {
        "kg_impact": 0.3,
        "hyp_quality": 0.25,
        "debate_depth": 0.2,
        "gap_addressed": 0.15,
        "research_depth": 0.1
      },
      "scored_at": "2026-04-28T01:28:15.061605+00:00",
      "dimension_notes": {
        "kg_impact": "kg_impact_score=0.0 (no direct edge tracking; = 0)",
        "hyp_quality": "avg_composite_score=0.7307 from 3 hypotheses",
        "debate_depth": "avg_debate_quality=0.780 × min(debate_count=1 / 3, 1) = 0.2600",
        "gap_addressed": "gap_id='gap-debate-20260412-094623-bb7e1c4f'",
        "research_depth": "total_hyps_generated=9"
      },
      "dimension_scores": {
        "kg_impact": 0,
        "hyp_quality": 0.730667,
        "debate_depth": 0.26,
        "gap_addressed": 1,
        "research_depth": 0.9
      },
      "world_model_rank": 0.474667
    }
  },
  "world_model_rank": 0.474667,
  "kg_impact_score": 0,
  "completed_at": "2026-04-26T15:23:04.935893-07:00",
  "report_url": "/analyses/SDA-2026-04-26-gap-debate-20260412-094623-bb7e1c4f",
  "reproducibility_class": "observational"
}
  2. v4
    4/26/2026, 3:23:04 PM
    Content snapshot 
    {
  "question": "What distinguishes seed-competent tau species from non-pathogenic tau during trans-synaptic transfer?",
  "domain": "neurodegeneration",
  "status": "completed",
  "triggered_by": "codex:aa724961",
  "gap_id": "gap-debate-20260412-094623-bb7e1c4f",
  "metadata": {
    "source": "scripts/generate_3_analyses.py",
    "dissent": [
      "The skeptic argued that many observed tau strains may be assay artifacts unless validated across PMCA, RT-QuIC, FRET biosensor, and in vivo spread systems.",
      "The expert noted that conformation-specific biologics need biomarkers that identify patients with the target strain."
    ],
    "task_id": "aa724961-6a40-495d-9c89-26dadaeda2bd",
    "consensus": [
      "Seed competence must be defined functionally by templating kinetics, not only by aggregate size or uptake.",
      "Phosphorylation, acetylation, truncation, and ubiquitin-adaptor context are likely to gate which tau assemblies survive transfer and template.",
      "Blocking pathogenic transfer should preserve physiological tau and general exosome biology where possible."
    ],
    "debate_summary": "The debate separated tau movement from tau templating. The strongest hypotheses focus on conformer state, post-translational modification barcodes, and vesicle/synapse context as jointly necessary for seed competence. The synthesis recommends paired structural and functional seeding assays rather than morphology-only tau aggregate comparisons."
  },
  "completed_at": "2026-04-26T15:23:04.935893-07:00",
  "report_url": "/analyses/SDA-2026-04-26-gap-debate-20260412-094623-bb7e1c4f"
}
  3. v3
    4/26/2026, 3:23:04 PM
    Content snapshot 
    {
  "question": "What distinguishes seed-competent tau species from non-pathogenic tau during trans-synaptic transfer?",
  "domain": "neurodegeneration",
  "status": "completed",
  "triggered_by": "codex:aa724961",
  "gap_id": "gap-debate-20260412-094623-bb7e1c4f",
  "metadata": {
    "source": "scripts/generate_3_analyses.py",
    "dissent": [
      "The skeptic argued that many observed tau strains may be assay artifacts unless validated across PMCA, RT-QuIC, FRET biosensor, and in vivo spread systems.",
      "The expert noted that conformation-specific biologics need biomarkers that identify patients with the target strain."
    ],
    "task_id": "aa724961-6a40-495d-9c89-26dadaeda2bd",
    "consensus": [
      "Seed competence must be defined functionally by templating kinetics, not only by aggregate size or uptake.",
      "Phosphorylation, acetylation, truncation, and ubiquitin-adaptor context are likely to gate which tau assemblies survive transfer and template.",
      "Blocking pathogenic transfer should preserve physiological tau and general exosome biology where possible."
    ],
    "debate_summary": "The debate separated tau movement from tau templating. The strongest hypotheses focus on conformer state, post-translational modification barcodes, and vesicle/synapse context as jointly necessary for seed competence. The synthesis recommends paired structural and functional seeding assays rather than morphology-only tau aggregate comparisons."
  },
  "completed_at": "2026-04-26T15:23:04.935893-07:00",
  "report_url": "/analyses/SDA-2026-04-26-gap-debate-20260412-094623-bb7e1c4f"
}
  4. v2
    4/26/2026, 3:23:04 PM
    Content snapshot 
    {
  "question": "What distinguishes seed-competent tau species from non-pathogenic tau during trans-synaptic transfer?",
  "domain": "neurodegeneration",
  "status": "completed",
  "triggered_by": "codex:aa724961",
  "gap_id": "gap-debate-20260412-094623-bb7e1c4f",
  "metadata": {
    "source": "scripts/generate_3_analyses.py",
    "dissent": [
      "The skeptic argued that many observed tau strains may be assay artifacts unless validated across PMCA, RT-QuIC, FRET biosensor, and in vivo spread systems.",
      "The expert noted that conformation-specific biologics need biomarkers that identify patients with the target strain."
    ],
    "task_id": "aa724961-6a40-495d-9c89-26dadaeda2bd",
    "consensus": [
      "Seed competence must be defined functionally by templating kinetics, not only by aggregate size or uptake.",
      "Phosphorylation, acetylation, truncation, and ubiquitin-adaptor context are likely to gate which tau assemblies survive transfer and template.",
      "Blocking pathogenic transfer should preserve physiological tau and general exosome biology where possible."
    ],
    "debate_summary": "The debate separated tau movement from tau templating. The strongest hypotheses focus on conformer state, post-translational modification barcodes, and vesicle/synapse context as jointly necessary for seed competence. The synthesis recommends paired structural and functional seeding assays rather than morphology-only tau aggregate comparisons."
  },
  "completed_at": "2026-04-26T15:23:04.935893-07:00",
  "report_url": "/analyses/SDA-2026-04-26-gap-debate-20260412-094623-bb7e1c4f"
}
  5. v1
    4/26/2026, 3:23:04 PM
    Content snapshot 
    {
  "question": "What distinguishes seed-competent tau species from non-pathogenic tau during trans-synaptic transfer?",
  "domain": "neurodegeneration",
  "status": "completed",
  "triggered_by": "codex:aa724961",
  "gap_id": "gap-debate-20260412-094623-bb7e1c4f",
  "metadata": {
    "source": "scripts/generate_3_analyses.py",
    "dissent": [
      "The skeptic argued that many observed tau strains may be assay artifacts unless validated across PMCA, RT-QuIC, FRET biosensor, and in vivo spread systems.",
      "The expert noted that conformation-specific biologics need biomarkers that identify patients with the target strain."
    ],
    "task_id": "aa724961-6a40-495d-9c89-26dadaeda2bd",
    "consensus": [
      "Seed competence must be defined functionally by templating kinetics, not only by aggregate size or uptake.",
      "Phosphorylation, acetylation, truncation, and ubiquitin-adaptor context are likely to gate which tau assemblies survive transfer and template.",
      "Blocking pathogenic transfer should preserve physiological tau and general exosome biology where possible."
    ],
    "debate_summary": "The debate separated tau movement from tau templating. The strongest hypotheses focus on conformer state, post-translational modification barcodes, and vesicle/synapse context as jointly necessary for seed competence. The synthesis recommends paired structural and functional seeding assays rather than morphology-only tau aggregate comparisons."
  },
  "completed_at": "2026-04-26T15:23:04.935893-07:00"
}