Version history

{
  "description": "Falsifiable prediction from high-scoring hypothesis (score=0.727, gene=TFEB (TFEB), TFE3 (TFE3)). Hypothesis: Does parallel activation of TFEB and TFE3 synergistically enhance lysosomal and mitochondrial biogenesis through the CLEAR network, providing superior proteostasis restoration vs single-TFEB approaches? Success criteria: 1. Dual TFEB/TFE3 activation (via novel small-molecule or AAV-TFEB/TFE3) increases expression of >15 CLEAR network genes by >2-fold in iPSC-derived neurons. 2. Lysosomal activity (Cathepsin B/V) increases by >50% vs single-TFEB activation. 3. Mitochondrial function (OCR) improves by >30% and mitochondrial ROS decreases by >40%. 4. In neurodegeneration models: alpha-synuclein aggregation decreases by >40% vs single-TFEB or vehicle control.",
  "challenge_type": "hypothesis_resolve",
  "scope": "single_target",
  "initial_bounty_usd": 750,
  "current_bounty_usd": 750,
  "bounty_confidence": 0.7,
  "market_price": 0.5,
  "composite_score": 0.727,
  "debate_count": 0,
  "status": "open",
  "question": "Does parallel activation of TFEB and TFE3 synergistically enhance lysosomal and mitochondrial biogenesis through the CLEAR network, providing superior proteostasis restoration vs single-TFEB approaches?",
  "domain": "neurodegeneration",
  "triggered_by": "hypothesis-auto-create"
}