Version history

{
  "description": "Falsifiable prediction from high-scoring hypothesis (score=0.729, gene=CDKN1A). Hypothesis: Does distinct phosphorylation state of p21^Cip1 predict cellular responsiveness to autophagy-inducing therapies, enabling precision stratification for mTOR-independent autophagy modulators in neurodegeneration? Success criteria: 1. Phospho-p21^T145 (non-apoptotic) vs phospho-p21^T148 (pro-autophagy) states are distinguishable by IP-WB in patient-derived fibroblasts. 2. p21^T148 phosphorylation correlates with LC3-II/LC3-I ratio >2.0 (autophagy flux) vs <1.0 in age-matched controls. 3. Autophagy inducer (e.g., carbamazepine) increases p21^T148 signal by >40% only in cells with high baseline p-Ser/Tyr ratio. 4. Patient-derived neurons with high p21^T148 show >30% reduction in polyQ aggregates after 72h autophagy inducer treatment.",
  "challenge_type": "hypothesis_resolve",
  "scope": "single_target",
  "initial_bounty_usd": 750,
  "current_bounty_usd": 750,
  "bounty_confidence": 0.7,
  "market_price": 0.5,
  "composite_score": 0.729356,
  "debate_count": 0,
  "status": "open",
  "question": "Does distinct phosphorylation state of p21^Cip1 predict cellular responsiveness to autophagy-inducing therapies, enabling precision stratification for mTOR-independent autophagy modulators in neurodegeneration?",
  "domain": "neurodegeneration",
  "triggered_by": "hypothesis-auto-create"
}