Version history

{
  "description": "Falsifiable prediction from high-scoring hypothesis (score=0.720, gene=C9orf72). Hypothesis: Does antisense oligonucleotide (ASO) targeting C9orf72 repeat expansions reduce TDP-43 mislocalization and restore motor function in ALS/FTD? Success criteria: 1. C9-ASO reduces GGGGCC repeat RNA foci by >60% in patient-derived motor neurons (72h post-treatment). 2. TDP-43 nuclear localization (nuclear/cytoplasmic ratio by IF) restores to >85% of control levels. 3. Poly(GP) DPR protein levels decrease by >50% in CSF from ASO-treated rodents. 4. Motor function (grid walk, rotarod) improves by >35% in ASO-treated ALS mouse model.",
  "challenge_type": "hypothesis_resolve",
  "scope": "single_target",
  "initial_bounty_usd": 250,
  "current_bounty_usd": 250,
  "bounty_confidence": 0.3,
  "market_price": 0.5,
  "composite_score": 0.72,
  "debate_count": 0,
  "status": "open",
  "question": "Does antisense oligonucleotide (ASO) targeting C9orf72 repeat expansions reduce TDP-43 mislocalization and restore motor function in ALS/FTD?",
  "domain": "neurodegeneration",
  "triggered_by": "hypothesis-auto-create"
}