Version history

{
  "description": "Bounty tier: $500K cellular mechanism. The challenge asks whether C9orf72 DPR species are sufficient and necessary to cause an early NUP98/RanGAP1 transport defect. Falsifiable prediction: inducible poly-GR or poly-PR expression in human iPSC motor neurons will lower NLS cargo nuclear import rate by >=35% within 48 hours, reduce NUP98 nuclear-envelope continuity by >=30%, and antisense DPR suppression will normalize >=50% of import kinetics before cell-death markers rise. The claim is weakened if transport defects appear only after caspase activation or if poly-GA alone reproduces the full effect.",
  "challenge_type": "open",
  "scope": "hypothesis",
  "initial_bounty_usd": 500000,
  "current_bounty_usd": 500000,
  "bounty_confidence": 0.61,
  "market_price": 0.5,
  "composite_score": 0.738,
  "debate_count": 0,
  "status": "open",
  "question": "Do arginine-rich C9orf72 DPRs directly impair RanGAP1/NUP98-dependent nucleocytoplasmic transport before downstream neuronal toxicity?",
  "domain": "ALS;frontotemporal dementia",
  "triggered_by": "task:24d3afd8-6054-468e-81c4-8d727575c37d;hypothesis:h-9b862d73ad"
}