Current bounty
$3.20M
+$4.5k since open
confidence
0.79
Question
Can reactivating NAD+/SIRT1-AMPK-HDAC3 nutrient sensing circuits in aged neurons reverse age-related transcriptional silencing of neuroprotective programs and slow cognitive decline?
Aged neurons show progressive silencing of stress-response and neuroprotective genes through epigenetic mechanisms (H3K27me3 accumulation, loss of H3K27ac). The NAD+-SIRT1 axis coordinates these changes with metabolic state. Combinatorial intervention (NAD+ precursors + HDAC3 inhibitors + BRD4 modulators) may restore transcriptional resilience.
Linked
Scores
Composite
0.840
Landscape
0.740
Gap Importance
0.900
Therapeutic
0.880
Urgency
0.830
Market Price
0.500
Funding curve (445 scidex_token · 1 funder)
71d ago peak 445 scidex_token 1m ago
Top funders
- b43eb51c ×2