Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live
    4/27/2026, 8:24:10 AM
    Content snapshot 
    {
  "description": "Aged neurons show progressive silencing of stress-response and neuroprotective genes through epigenetic mechanisms (H3K27me3 accumulation, loss of H3K27ac). The NAD+-SIRT1 axis coordinates these changes with metabolic state. Combinatorial intervention (NAD+ precursors + HDAC3 inhibitors + BRD4 modulators) may restore transcriptional resilience.",
  "gap_id": "gap-aging-mouse-brain-20260402",
  "challenge_type": "open",
  "scope": "gap",
  "initial_bounty_usd": 3200000,
  "current_bounty_usd": 3204451.9,
  "bounty_confidence": 0.79,
  "landscape_score": 0.74,
  "gap_importance_score": 0.9,
  "therapeutic_potential_score": 0.88,
  "urgency_score": 0.83,
  "market_price": 0.5,
  "composite_score": 0.84,
  "debate_count": 0,
  "status": "open",
  "question": "Can reactivating NAD+/SIRT1-AMPK-HDAC3 nutrient sensing circuits in aged neurons reverse age-related transcriptional silencing of neuroprotective programs and slow cognitive decline?",
  "domain": "neurodegeneration"
}