Version history

{
  "description": "Bounty tier: $500K ALS autophagy validation. The challenge distinguishes defective receptor recruitment from generic stress-granule overproduction. Falsifiable prediction: TBK1 loss-of-function or kinase inhibition in iPSC motor neurons will reduce phospho-SQSTM1/OPTN recruitment to G3BP1 granules by >=50%, extend granule half-life after arsenite washout from <60 minutes to >180 minutes, and phosphomimetic OPTN/SQSTM1 rescue will normalize >=40% of G3BP1 clearance. If autophagic flux enhancement clears granules without receptor recruitment rescue, the receptor-trapping model is falsified.",
  "challenge_type": "open",
  "scope": "hypothesis",
  "initial_bounty_usd": 500000,
  "current_bounty_usd": 500000,
  "bounty_confidence": 0.6,
  "market_price": 0.5,
  "composite_score": 0.737,
  "debate_count": 0,
  "status": "open",
  "question": "Does impaired TBK1 phosphorylation of SQSTM1/OPTN/NDP52 prevent autophagic clearance of G3BP1 stress granules and drive persistent pathological granules?",
  "domain": "ALS;stress granules;autophagy",
  "triggered_by": "task:24d3afd8-6054-468e-81c4-8d727575c37d;hypothesis:h-0c2927c851"
}