Version history

{
  "description": "Bounty tier: $250K delivery feasibility. This challenge tests both CNS delivery and microglial cell-state effect, the two largest uncertainties in the drug-delivery hypothesis. Falsifiable prediction: AAV-PHP.eB-CX3CR1-IGFBPL1 will transduce >=25% of microglia in mouse cortex/hippocampus, increase microglial IGFBPL1 expression >=5x, reduce Il1b/Tnf/Nlrp3 expression by >=30%, and improve NeuN+ neuronal survival by >=20% in an LPS or 5xFAD inflammatory model versus empty-vector control. Failure to achieve microglial transduction above 10% falsifies the proposed delivery route.",
  "challenge_type": "open",
  "scope": "hypothesis",
  "initial_bounty_usd": 250000,
  "current_bounty_usd": 250000,
  "bounty_confidence": 0.54,
  "market_price": 0.5,
  "composite_score": 0.73588,
  "debate_count": 0,
  "status": "open",
  "question": "Can AAV-PHP.eB delivery of IGFBPL1 to microglia shift disease-associated microglia toward a protective phenotype and improve neuronal survival?",
  "domain": "drug delivery;microglia",
  "triggered_by": "task:24d3afd8-6054-468e-81c4-8d727575c37d;hypothesis:h-811520b92f"
}