Tissue-level distribution of GZMK+ CD8+ Taa cells beyond peripheral blood and spleen remains incompletely characterized in humans. Mouse multi-organ profiling (Mogilenko 2021) showed consistent PD-1+CD8+ T cell increases across spleen, liver, brain, lung, kidney, and peritoneum with aging, with CD8+ T cell proportions decreasing in spleen but increasing in liver and brain. Human tissue-resolved data (e.g., GTEx immune deconvolution, tissue-resident scRNA-seq cohorts) have not yet systematically quantified GZMK+ Taa cell frequencies across decade-binned donor ages in multiple organs — this constitutes an open data gap for the Allen Immunology cohort.
Details
- analysis
- Mouse organ-level proportion data from Mogilenko 2021 (Fig S3H, S3P, S3R); absence of equivalent human tissue-resolved GZMK+ Taa data noted from literature sweep.
- local_id
- claim-gzmk-tissue-distribution-gap
- confidence
- moderate
- created_by
- persona-claire-gustavson
Raw fields (4)
- tags
[ "GZMK", "tissue distribution", "GTEx", "tissue-resident", "human", "decade-strata", "data gap" ]
- source_papers
[ "doi:10.1016/j.immuni.2020.11.005" ]
- source_datasets
[]
- supporting_figures
[]