Version history

{
  "tags": [
    "GZMK",
    "tissue distribution",
    "GTEx",
    "tissue-resident",
    "human",
    "decade-strata",
    "data gap"
  ],
  "text": "Tissue-level distribution of GZMK+ CD8+ Taa cells beyond peripheral blood and spleen remains incompletely characterized in humans. Mouse multi-organ profiling (Mogilenko 2021) showed consistent PD-1+CD8+ T cell increases across spleen, liver, brain, lung, kidney, and peritoneum with aging, with CD8+ T cell proportions decreasing in spleen but increasing in liver and brain. Human tissue-resolved data (e.g., GTEx immune deconvolution, tissue-resident scRNA-seq cohorts) have not yet systematically quantified GZMK+ Taa cell frequencies across decade-binned donor ages in multiple organs — this constitutes an open data gap for the Allen Immunology cohort.",
  "analysis": "Mouse organ-level proportion data from Mogilenko 2021 (Fig S3H, S3P, S3R); absence of equivalent human tissue-resolved GZMK+ Taa data noted from literature sweep.",
  "local_id": "claim-gzmk-tissue-distribution-gap",
  "confidence": "moderate",
  "source_papers": [
    "doi:10.1016/j.immuni.2020.11.005"
  ],
  "source_datasets": [],
  "supporting_figures": [],
  "created_by": "persona-claire-gustavson"
}