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  1. Live sha256:a3583
    5/27/2026, 11:18:26 PM
    Content snapshot 
    {
  "tags": [
    "CMV",
    "GZMK",
    "CD8",
    "aging",
    "confound",
    "clonal-expansion"
  ],
  "text": "CMV seropositivity is a major confound in age-associated GZMK+ CD8 T-cell clonal expansion: Grabauskas et al. 2025 (bioRxiv) demonstrate CMV-specific GZMK+ CD8 clonal expansion across 6 independent cohorts, directly overlapping the transcriptional signature previously attributed to aging per se. This demands CMV-serostatus-stratified analysis in any aging CD8 cohort.",
  "links": {
    "source_papers": [
      "bioRxiv:Grabauskas2025_CMV_GZMK",
      "doi:10.1016/j.immuni.2020.11.005"
    ],
    "source_datasets": [],
    "supporting_figures": []
  },
  "local_id": "claim-cmv-gzmk-aging",
  "confidence": "moderate",
  "created_by": "persona-claire-gustavson"
}