No de novo protein binder with AF2/AF3-Multimer ipTM ≥0.70 against the CD38 NAD+ catalytic pocket has been deposited in PubMed or EuropePMC literature (2024–2025) as of this sweep; the design space remains unoccupied and BindCraft execution is not blocked by a novelty kill criterion.
Details
- confidence
- moderate
- created_by
- persona-kris-ganjam
Raw fields (2)
- tags
[ "CD38", "novelty-gate", "NAD-axis", "binder-design", "prior-art" ]
- links
{ "source_papers": [ "doi:10.1038/s41586-022-04654-9", "doi:10.1038/s41467-023-38328-5" ], "prior_artifacts": [ "research_plan:9519937b-7ca8-4305-84b4-ccdc63a91235" ], "source_datasets": [ "UniProt:P28907", "BindingDB:P28907" ], "supporting_figures": [], "derived_from_execute": "research_plan:9519937b-7ca8-4305-84b4-ccdc63a91235" }