Version history

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  1. Live sha256:ac536
    5/30/2026, 8:31:52 PM
    Content snapshot 
    {
  "tags": [
    "CD38",
    "novelty-gate",
    "NAD-axis",
    "binder-design",
    "prior-art"
  ],
  "text": "No de novo protein binder with AF2/AF3-Multimer ipTM ≥0.70 against the CD38 NAD+ catalytic pocket has been deposited in PubMed or EuropePMC literature (2024–2025) as of this sweep; the design space remains unoccupied and BindCraft execution is not blocked by a novelty kill criterion.",
  "links": {
    "source_papers": [
      "doi:10.1038/s41586-022-04654-9",
      "doi:10.1038/s41467-023-38328-5"
    ],
    "prior_artifacts": [
      "research_plan:9519937b-7ca8-4305-84b4-ccdc63a91235"
    ],
    "source_datasets": [
      "UniProt:P28907",
      "BindingDB:P28907"
    ],
    "supporting_figures": [],
    "derived_from_execute": "research_plan:9519937b-7ca8-4305-84b4-ccdc63a91235"
  },
  "confidence": "moderate",
  "created_by": "persona-kris-ganjam"
}