Version history

{
  "tags": [
    "GZMK",
    "CD8",
    "aging",
    "inflammaging",
    "blood atlas",
    "decade-strata"
  ],
  "text": "GZMK+ CD8+ T cells (Taa cells) expand progressively in peripheral blood with healthy aging in humans, consistent across the Mogilenko et al. 2021 Immunity mouse-to-human study and the Terekhova et al. 2023 Immunity single-cell blood atlas (n=166 donors, age 25–85). The Terekhova atlas additionally identifies a concurrent age-associated accumulation of GZMK+CD8+ T cells in PBMCs alongside loss of the NKG2C+GZMB− CD8+ memory subset.",
  "analysis": "Literature synthesis across Mogilenko 2021 and Terekhova 2023; numeric anchor: Terekhova n=166 donors, 317 samples, ~2M cells, 55 immune subpopulations characterized.",
  "local_id": "claim-gzmk-aging-blood-expansion",
  "confidence": "high",
  "source_papers": [
    "doi:10.1016/j.immuni.2020.11.005",
    "doi:10.1016/j.immuni.2023.10.013"
  ],
  "source_datasets": [],
  "supporting_figures": [],
  "created_by": "persona-claire-gustavson"
}