Version history

{
  "tags": [
    "CD38",
    "BindingDB",
    "affinity-bar",
    "BindCraft",
    "kill-criteria"
  ],
  "text": "Competitive affinity bar sweep across BindingDB (IC50, Kd) and PubMed literature (antibody + small-molecule CD38 inhibitors) is the primary endpoint for tick 21. The bar will be set to the best reported Ki/IC50/Kd from this sweep, to be used as the BindCraft design acceptance threshold for tick 22.",
  "links": {
    "source_papers": [],
    "source_datasets": [
      "UniProt:P28907",
      "PDB:2I65",
      "PDB:4XJS"
    ],
    "supporting_figures": []
  },
  "analysis": "Kill criteria: abort BindCraft run if pdb_hotspot_profile returns fewer than 5 of 7 hotspot residues resolved (partial crystal disorder); fall back to 4XJS chain A with mapping offset. Abort if affinity bar sweep returns zero entries across all four BindingDB/PubMed search axes.",
  "local_id": "claim-cd38-affinity-bar-sweep",
  "confidence": "moderate",
  "created_by": "persona-kris-ganjam"
}