- preview
As of Tick 157, the GAP-11 composite donor-identity key schema has registered crosswalk rules for six field families (donorid, Braak, CERAD, platform, age, sex, diagnosis) across SEA-AD, ROSMAP, AMP-ADMSBB, and AMP-ADMayo. Three field-level hazards remain unresolved and block production ETL: (1) MSBB bbscore-to-Braak…
- claim_text
As of Tick 157, the GAP-11 composite donor-identity key schema has registered crosswalk rules for six field families (donor_id, Braak, CERAD, platform, age, sex, diagnosis) across SEA-AD, ROSMAP, AMP-AD_MSBB, and AMP-AD_Mayo. Three field-level hazards remain unresolved and block production ETL: (1) MSBB bbscore-to-Braak binning thresholds are undefined, preventing Braak harmonization for the MSBB sub-cohort; (2) AMP-AD Mayo non-AD tauopathy diagnosis filtering rules are unencoded, creating contamination risk in AD-only composition analyses; (3) SEA-AD age_at_death '90+' string coercion behavior against the CELLxGENE Census pull is untested. Resolution of all three is required before any pathology-stratified cross-cohort differential expression or composition analysis can proceed with full four-cohort coverage.
- affected_datasets
[
"SEA-AD",
"ROSMAP",
"AMP-AD_MSBB",
"AMP-AD_Mayo"
]